Results | viHumans

UniProt ID

Q9WT45

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

U19[Gene ID: 1497015 ]

Protein Name

Apoptosis inhibitor U19

Organism Name

Human Herpesvirus 6B (strain Z29) (HHV-6 Variant B) (Human B Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Herpesvirus 6B (HHV-6 Variant B) (Human B Lymphotropic Virus)> Human Herpesvirus 6B (strain Z29) (HHV-6 Variant B) (Human B Lymphotropic Virus)

RefSeq

NC_000898.1 ; AF157706.1

PubMed ID

10482554 ; 10482553 ; 23555634 ; 24314634

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1497015

Reactome

Not Available

Sequence

							MAFTGDELARMLQFKDKMISSAGSALRFEKVVQEAMASGIVLQHITCIKVRICDNSDILSDRQLRCLLINGLYPFEGRMSMFGVTEEWEGASAAPERQVV
FLLSSTGQVLGYEDGVIFYLSPTFSDFWTTAMEFSCQNAILSNFIAQKSRDEYSDQFQKYFTRMRHTPISLTGVLPRRFQKVESGACVEEDARASMRPIQ
SDSFGAKGPFCWPTEELLQPSAKKDVGGTVCMALSCQEDNSARHCTIYGLTKTPGIKIMLSRHTQTDRSEAMCDAATQTEDVVDNSSETLFLGGNLVHQS
ILETEVQATAKNTFDVSDPRIDSVYDTTVVGAMATDDVGCKHVQGGASLAQEKPLKGYCIIATPSECKPNIHWLKSPENAVHESAAVLR
						

Length

389

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1999

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2.

EC

Not Available

Experimentally known GO terms

GO:0030430 ; GO:0039526 ; GO:0042025 ; GO:0071157

Subcellular Location

Host cytoplasm HG98. Host nucleus . Note=localized in the host nucleus at early times postinfection and then increases in both nuclear and cytoplasmic compartments during the course of infection. HG98.

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available