Results | viHumans

UniProt ID

Q9WH76

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Phlebotominae (sandflies) [TaxID: 7198]

Gene Name

M[Gene ID: 14857909 ]

Protein Name

Matrix protein

Organism Name

Chandipura Virus (strain I653514) (CHPV)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Rhabdoviridae> Vesiculovirus> Chandipura Vesiculovirus> Chandipura Virus> Chandipura Virus (strain I653514) (CHPV)

RefSeq

NC_020805.1 ; GU212856.1

PubMed ID

10595413

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:14857909

Reactome

Not Available

Sequence

							MQRLKKFIAKREKGDKGKMKWNSSMDYDSPPSYQDVRRGIFPTAPLFGMEDDMMEFTPSLGIQTLKLQYKCVVNINAINPFRDFREAISAMQFWEADYSG
YIGKKPFYRAIILHTARQLKTSNPGILDRGVVEYHATTQGRALVFHSLGPSPSMMFVPETFTREWNILTNKGTINVKIWLGETDTLSELEPILNPVNFRD
DREMIEGAAIMGLEIKKQKDNTWLISKSH
						

Length

229

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1999

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a major role in assembly and budding of virion. Condensates the ribonucleocapsid core during virus assembly. Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex. This shutoff presumably inhibit interferon signaling and thus establishment of antiviral state in virus infected cells. Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0019031 ; GO:0033645 ; GO:0039660 ; GO:0039702 ; GO:0055036

Subcellular Location

♦ Virion membrane
♦ Peripheral membrane protein. Host endomembrane system
♦ Peripheral membrane protein .

Domain(s)

Not Available

Motif(s)

MOTIF 30 33 PPXY motif.; MOTIF 42 45 PTAP/PSAP motif.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available