Reviewed
Homo Sapiens (Human) [TaxID: 9606]
U53[Gene ID: 1497055 ]
♦Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) (Protease)
♦ Assembly protein (Capsid assembly protein)]
♦ Assembly protein (Capsid assembly protein)]
Human Herpesvirus 6B (strain Z29) (HHV-6 Variant B) (Human B Lymphotropic Virus)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Herpesvirus 6B (HHV-6 Variant B) (Human B Lymphotropic Virus)> Human Herpesvirus 6B (strain Z29) (HHV-6 Variant B) (Human B Lymphotropic Virus)
Various pathway(s) in which protein is involved
Not Available
MSKVWVGGFLCVYGEEPSEECLALPRDTVQKELRSGNIPLPLNINHNEKATIGMVRGLFDLEHGLFCVAQIQSQTFMDIIRNIASKSKLIAAGSVIEPLP
PDPEIECLSSSFPGLSLSSKVLQDENLDGKPFFHHVSVCGVGRRPGTIAIFGREISWILDRFSCISESEKRQVLEGVNVYSQGFDENLFSADLYDLLADS
LDTSYIRKRFPKLQLDKQLCGLSKCTYIKASEPPVEIIVATGKVAGDQVQLTTEPGSELAVETCDVSVVHGNYDAVESATATTAMSNQNLPNTTPLLSSP
PFSDCVFLPKDAFFSLLNVTTGQQPKVVPPVSVHPPVTEQYQMLPYSESAAKIAEQESNRYHSPCQTMYPYWQYSPVPQYPAVLHGYRQPKTFKKRHFQS
DSEDELSFPGDPEYTKKRRRHKVDNDDDKEMAREKNDLRELVDMIGMLRQEINALKHVRAQSPQRHVVPMETLPTIEEKGAASPKPSILNASLTPETVNR
SLAGQNESMDLLKLNKKLFVDALNKMDS
PDPEIECLSSSFPGLSLSSKVLQDENLDGKPFFHHVSVCGVGRRPGTIAIFGREISWILDRFSCISESEKRQVLEGVNVYSQGFDENLFSADLYDLLADS
LDTSYIRKRFPKLQLDKQLCGLSKCTYIKASEPPVEIIVATGKVAGDQVQLTTEPGSELAVETCDVSVVHGNYDAVESATATTAMSNQNLPNTTPLLSSP
PFSDCVFLPKDAFFSLLNVTTGQQPKVVPPVSVHPPVTEQYQMLPYSESAAKIAEQESNRYHSPCQTMYPYWQYSPVPQYPAVLHGYRQPKTFKKRHFQS
DSEDELSFPGDPEYTKKRRRHKVDNDDDKEMAREKNDLRELVDMIGMLRQEINALKHVRAQSPQRHVVPMETLPTIEEKGAASPKPSILNASLTPETVNR
SLAGQNESMDLLKLNKKLFVDALNKMDS
528
VAR_SEQ 1 284 Missing (in isoform pAP)
Not Available
01-05-2000
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦Capsid scaffolding protein: Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.
♦ Assemblin: Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging.
♦ Assembly protein: Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.
♦ Assemblin: Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging.
♦ Assembly protein: Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.
3.4.21.97
♦ Capsid scaffolding protein: Host cytoplasm .
♦ Assemblin: Host nucleus .
♦ Assembly protein: Host nucleus .
♦ Assemblin: Host nucleus .
♦ Assembly protein: Host nucleus .
Not Available
MOTIF 416 422 Nuclear localization signal.
Predicted/Modelled
Not Available
♦ACT_SITE 46 46 Charge relay system.
♦ ACT_SITE 116 116 Charge relay system.
♦ ACT_SITE 135 135 Charge relay system.
♦ ACT_SITE 116 116 Charge relay system.
♦ ACT_SITE 135 135 Charge relay system.
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available