Results | viHumans

UniProt ID

Q9PZT1

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Ns

Protein Name

Non-structural protein 1

Organism Name

Human Parvovirus B19 (strain HV) (HPV B19)

Taxonomic Lineage

Viruses> SsDNA Viruses> Parvoviridae> Parvovirinae> Erythroparvovirus> Primate Erythroparvovirus 1> Human Parvovirus B19 (HPV B19)> Human Parvovirus B19 (strain HV) (HPV B19)

RefSeq

Not Available

PubMed ID

8970971 ; 9525624 ; 15518826 ; 20890043 ; 24049177 ; 24418564

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MELFRGVLQVSSNVLDCANDNWWCSLLDLDTSDWEPLTHTNRLMAIYLSSVASKLDFTGGPLAGCLYFFQVECNKFEEGYHIHVVIGGPGLNPRNLTVCV
EGLFNNVLYHLVTENVKLKFLPGMTTKGKYFRDGEQFIENYLMKKIPLNVVWCVTNIDGYIDTCISATFRRGACHAKKPRITTAINDTSSDAGESSGTGA
EVVPINGKGTKASIKFQTMVNWLCENRVFTEDKWKLVDFNQYTLLSSSHSGSFQIQSALKLAIYKATNLVPTSTFLLHTDFEQVMCIKDNKIVKLLLCQN
YDPLLVGQHVLKWIDKKCGKKNTLWFYGPPSTGKTNLAMAIAKSVPVYGMVNWNNENFPFNDVAGKSLVVWDEGIIKSTIVEAAKAILGGQPTRVDQKMR
GSVAVPGVPVVITSNGDITFVVSGNTTTTVHAKALKERMVKLNFTVRCSPDMGLLTEADVQQWLTWCNAQSWDHYENWAINYTFDFPGINADALHPDLQT
TPIVTDTSISSSGGESSEELSESSFFNLITPGAWNTETPRSSTPIPGTSSGESFVGSSVSSEVVAASWEEAFYTPLADQFRELLVGVDYVWDGVRGLPVC
CVQHINNSGGGLGLCPHCINVGAWYNGWKFREFTPDLVRCSCHVGASNPFSVLTCKKCAYLSGLQSFVDYE
						

Length

671

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-05-2000

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Multifunctional protein that plays an essential role in viral DNA replication. Interacts with host E2F4 and E2F5 and thereby inhibits the host cell cycle G2/M transition. This arrest provides essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and may play a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Promotes apoptosis in erythroid lineage cells.

EC

Not Available

Experimentally known GO terms

GO:0005524 ; GO:0019051 ; GO:0019056 ; GO:0039592 ; GO:0039685 ;
GO:0042025

Subcellular Location

Not Available

Domain(s)

DOMAIN 302 457 SF3 helicase.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available