Reviewed
Homo Sapiens (Human) [TaxID: 9606]
VGF TC18R
Pro-vaccinia growth factor (Pro-VGF) [Cleaved into: Vaccinia growth factor (VGF) (Secreted epidermal growth factor-like)]
Vaccinia Virus (strain Tian Tan) (VACV)
Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Vaccinia Virus> Vaccinia Virus (strain Tian Tan) (VACV)
Not Available
Various pathway(s) in which protein is involved
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MLINYLMLLFAAMIIRSFADSGNAIETTLPEITNATTDIPAIRLCGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSY
IPSPGIMLVLVGIIIITCCLLSVYRFTRRTKLPLQDMVVP
IPSPGIMLVLVGIIIITCCLLSVYRFTRRTKLPLQDMVVP
140
Not Available
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01-10-2000
Inferred from homology
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
---|---|---|---|---|---|
Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
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Vaccinia growth factor stimulates cellular proliferation (hyperplasia) around infected cells. This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells. Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival. The activation by host EFGR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo (By similarity).
Not Available
♦ Pro-vaccinia growth factor: Host membrane
♦ Single-pass type I membrane protein .
♦ Vaccinia growth factor: Secreted .
♦ Single-pass type I membrane protein .
♦ Vaccinia growth factor: Secreted .
DOMAIN 41 81 EGF-like.
Not Available
Predicted/Modelled
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Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
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- Million Molecules
Best 20 Hit molecules
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