Reviewed
Homo Sapiens (Human) [TaxID: 9606]
ORF1
♦Non-structural polyprotein 1AB [Cleaved into: VPg
♦ Protein p19
♦ Transmembrane protein 1A
♦ Serine protease p27 (p27) (EC 3.4.21.-)
♦ Protein p20
♦ RNA-directed RNA polymerase p57 (p57) (EC 2.7.7.48)]
♦ Protein p19
♦ Transmembrane protein 1A
♦ Serine protease p27 (p27) (EC 3.4.21.-)
♦ Protein p20
♦ RNA-directed RNA polymerase p57 (p57) (EC 2.7.7.48)]
Human Astrovirus-8 (HAstV-8)
Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Astroviridae> Mamastrovirus> Mamastrovirus 1> Human Astrovirus-8 (HAstV-8)
Not Available
Various pathway(s) in which protein is involved
Not Available
Not Available
MMALGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQAYDWIVRGLIFPTTGKTYFQRVVVITGGLEDGTYGSYAFNGSEWVEIYPIEHLNL
MSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKELIPKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQTNNTIFTDMIAACKYSTETLTE
NLDLRIKLALANITINDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLW
VMNTLMVCYYFDNLLAITMAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVV
ATVPTRIKNVAFDFFQKLKQSGVRVGVNDFVVIKPGALCIIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVSVCYEGLVYEAKVRYMPEKDIAFITCPGDL
HPTARLKLSKNPDYSCVTVMAYVNEDLVVSTATAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEE
IERLKAQLNSAAENPVTVVTQQPIVTLEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEK
GLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPTPAPRTTKPKPCPEPKIEAQPLDLSQKKEKQPEHEQQVAKP
TKPQKIEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSK
KQGPKKLQRAPEDQGAQNYHSLDAWKSLLEPPRERRCVPANFPLLGHLPINRPIFDDKKPRDDLLGLLPEPTWHAFEEYGPTTWGPQAFVKSFDKFFYAE
PIDFFSEYPQLCAFADWATYREFRYLEDTRVIHITATEKNTDSTPAYPKMNYFDTEEDYLEAHGWAPYIREFTRVFKGDKPEVLWYLFLKKEIIKEEKIR
NSDIRQIVCADPIYTRIGACLEAHQNALMKQHTDTSVGQCGWSPMEGGFKKTMQRLVNKGNKHFIEFDWTRYDGTIPPALFKHIKEIRWNFINKDQREKY
RHVHEWYVDNLLNRHVLLPSGEVTLQTRGNPSGQFSTPMDNNMVNFWLQAFEFAYFNGPDKDLWKTYDTVVYGDDRLSTTPSVPDNYEERVITMYRDIFG
MWVKPGKVICRDSIVGLSFCGFTVNENLEPVPTSPEKLMASLLKPYKILPDLESLHGKLLCYQLLAAFMAEDHPFKVYVEHCLSRTAKQLRDSGLPARLT
EEQLHRIWRGGPKKCDG
MSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKELIPKPEPRKIQMKWIIVGAVLTFLSLIPGGYAQSQTNNTIFTDMIAACKYSTETLTE
NLDLRIKLALANITINDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLITLATSHLSGFRMAVLPTIPFHTTMTLW
VMNTLMVCYYFDNLLAITMAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVV
ATVPTRIKNVAFDFFQKLKQSGVRVGVNDFVVIKPGALCIIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVSVCYEGLVYEAKVRYMPEKDIAFITCPGDL
HPTARLKLSKNPDYSCVTVMAYVNEDLVVSTATAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEE
IERLKAQLNSAAENPVTVVTQQPIVTLEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEK
GLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPTPAPRTTKPKPCPEPKIEAQPLDLSQKKEKQPEHEQQVAKP
TKPQKIEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSK
KQGPKKLQRAPEDQGAQNYHSLDAWKSLLEPPRERRCVPANFPLLGHLPINRPIFDDKKPRDDLLGLLPEPTWHAFEEYGPTTWGPQAFVKSFDKFFYAE
PIDFFSEYPQLCAFADWATYREFRYLEDTRVIHITATEKNTDSTPAYPKMNYFDTEEDYLEAHGWAPYIREFTRVFKGDKPEVLWYLFLKKEIIKEEKIR
NSDIRQIVCADPIYTRIGACLEAHQNALMKQHTDTSVGQCGWSPMEGGFKKTMQRLVNKGNKHFIEFDWTRYDGTIPPALFKHIKEIRWNFINKDQREKY
RHVHEWYVDNLLNRHVLLPSGEVTLQTRGNPSGQFSTPMDNNMVNFWLQAFEFAYFNGPDKDLWKTYDTVVYGDDRLSTTPSVPDNYEERVITMYRDIFG
MWVKPGKVICRDSIVGLSFCGFTVNENLEPVPTSPEKLMASLLKPYKILPDLESLHGKLLCYQLLAAFMAEDHPFKVYVEHCLSRTAKQLRDSGLPARLT
EEQLHRIWRGGPKKCDG
1417
Not Available
Not Available
08-04-2008
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦Non-structural polyprotein 1AB: contains the viral protease participating in the cleavage of the polyprotein into functional products. It contains also the activities necessary for replication of genomic RNA, as well as transcription of subgenomic mRNA.
♦ VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.
♦ VPg: protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.
3.4.21.- , 2.7.7.48
GO:0003723 ; GO:0003968 ; GO:0004252 ; GO:0005524 ; GO:0006351 ;
GO:0008234 ; GO:0016021 ; GO:0033644 ; GO:0039694 ; GO:0070008
GO:0008234 ; GO:0016021 ; GO:0033644 ; GO:0039694 ; GO:0070008
♦ Host membrane
♦ Multi-pass membrane protein .
♦ Multi-pass membrane protein .
DOMAIN 1162 1288 RdRp catalytic.
Not Available
Predicted/Modelled
Not Available
♦ACT_SITE 462 462 Charge relay system
♦ for serine protease activity.
♦ ACT_SITE 490 490 Charge relay system
♦ for serine protease activity.
♦ ACT_SITE 552 552 Charge relay system
♦ for serine protease activity.
♦ for serine protease activity.
♦ ACT_SITE 490 490 Charge relay system
♦ for serine protease activity.
♦ ACT_SITE 552 552 Charge relay system
♦ for serine protease activity.
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available