Reviewed
Homo Sapiens (Human) [TaxID: 9606]
NPH1 MC100L[Gene ID: 1487119 ]
Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)
Molluscum Contagiosum Virus Subtype 1 (MOCV) (MCVI)
Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Molluscipoxvirus> Molluscum Contagiosum Virus> Molluscum Contagiosum Virus Subtype 1 (MOCV) (MCVI)
Various pathway(s) in which protein is involved
Not Available
MNLHAAYIDYALRRSQHMQAEMSGADNVLLKDYQLFVAKVFLGLDSMNSLLLFQETGVGKTVTAVYMLKHLRFLYTSWTVLVLVKKALVEEPWMNTILRF
APEVAKDCVFMNYDDQNFHNKFFTNIKTVSARSRIFVIIDECHNFISKSLSREDGRARNTKHVYNFLARHIASSHNKLLCLSATPIVNNVREFALLVNLL
RPGVLPPQSLFHNKRLLDEAELVSKLGCICSYLVHHEASIFEDVEGSELFARKRVLLKYVRMSAKQEDIYHKARAAEFRSGIAVFRVHRRMAATFAFDEF
PVRKNLTPDEYDALVASLVRDFEALFAGRALSDATRARLRAGEPIECAASAEDLSLYQALYEHSCKYAEVCVAILASPGKCLVFEPFINLSGIRIFVKYL
EVFGISYIEFSSRTKDTRTRAVAEFNRVENTNGELIKTCVFSLSGNEGISFLSINDIFILDMTWNEASLKQIIGRAIRLHSHANNPPERRYVNVHFVVAQ
LGSGAPSVDDDLLEIIQNKAREFSQLYRVLKLASIEWIHQHCREFAPVDDEAGFRALCSRAIDVTRGASTRRALATGENIWYAFSTLMITVHPGFKTEDG
RVYDADGNFLTTMPERPIVRVQGTRLVYIFPELR
APEVAKDCVFMNYDDQNFHNKFFTNIKTVSARSRIFVIIDECHNFISKSLSREDGRARNTKHVYNFLARHIASSHNKLLCLSATPIVNNVREFALLVNLL
RPGVLPPQSLFHNKRLLDEAELVSKLGCICSYLVHHEASIFEDVEGSELFARKRVLLKYVRMSAKQEDIYHKARAAEFRSGIAVFRVHRRMAATFAFDEF
PVRKNLTPDEYDALVASLVRDFEALFAGRALSDATRARLRAGEPIECAASAEDLSLYQALYEHSCKYAEVCVAILASPGKCLVFEPFINLSGIRIFVKYL
EVFGISYIEFSSRTKDTRTRAVAEFNRVENTNGELIKTCVFSLSGNEGISFLSINDIFILDMTWNEASLKQIIGRAIRLHSHANNPPERRYVNVHFVVAQ
LGSGAPSVDDDLLEIIQNKAREFSQLYRVLKLASIEWIHQHCREFAPVDDEAGFRALCSRAIDVTRGASTRRALATGENIWYAFSTLMITVHPGFKTEDG
RVYDADGNFLTTMPERPIVRVQGTRLVYIFPELR
634
Not Available
Not Available
01-02-1997
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts. Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex. NPH-I must bind ssDNA in order to exhibit ATPase activity (By similarity).
3.6.1.15
Virion . Note=Virion core enzyme. .
♦DOMAIN 41 203 Helicase ATP-binding.
♦ DOMAIN 355 531 Helicase C-terminal.
♦ DOMAIN 355 531 Helicase C-terminal.
MOTIF 140 143 DEXH box.
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available