Results | viHumans

UniProt ID

Q98262

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

VETFS MC095R[Gene ID: 1487114 ]

Protein Name

Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small subunit)

Organism Name

Molluscum Contagiosum Virus Subtype 1 (MOCV) (MCVI)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Molluscipoxvirus> Molluscum Contagiosum Virus> Molluscum Contagiosum Virus Subtype 1 (MOCV) (MCVI)

RefSeq

NC_001731.1 ; U60315.1

PubMed ID

8670425

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487114

Reactome

Not Available

Sequence

							MNLGIVSLFREHVDSIPNILPHQLATLDFLLRSILDENNSVLLFHIMGSGKTIIALLFALIVSKFKKVYILVPNINILKIFTYNMGIAVNLINSDYVLEN
IHIYSTTSFYSLNYNDNVINYNGLAKYNNAIFIIDEAHNIFGNNTGELMTVIKNKNKVPFLLLSGSPITNTPITLSNIISIMSDEGINFSDIIIQGKKVF
QILLNENGVSVLKRILRDKISYYELQDTELPSIVFHGRRFLDTRIVYCHMSKLQERDYINVRKLCNNEMFEKNMNNVSLAVLGPLNLINNLDILFQDQDK
ELYPNLKISNGVLYGDELVSLNISSKFKYFIARIQSLTGKHFIYFSNSTYGGLIIKYIMLSNGYSEHNGSQGTNPKTIGGRLKTFAIVTSKMKSSLEELL
AVYNSPANNDGSRIMFLFSSNIMSESYTLKEVMHIWFMTIPDTFSQYNQILGRSIRKFSYTNIAEPVNVYLLAAIYADFDDDITSLDNYSIDEINVLPFD
IKKLLYLKFKTKETKRIYSILKDISVNYTLPPHPQIVDVVLGELTRQFFYHHSRVRADDPELFAAIDRVLCSPDSTRRYLDEITRGHFFVCNRVFEKALL
YRHGEDIIVVPFKLSHDQFLWAINFRKEYNVGAPL
						

Length

635

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1997

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters (By similarity).

EC

3.6.4.-

Experimentally known GO terms

GO:0003677 ; GO:0004386 ; GO:0005524 ; GO:0006351 ; GO:0006355 ;
GO:0019012

Subcellular Location

Virion . Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.

Domain(s)

DOMAIN 32 185 Helicase ATP-binding.

Motif(s)

MOTIF 135 138 DEXH box.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available