Reviewed
Homo Sapiens (Human) [TaxID: 9606]
NPH2 50R[Gene ID: 1670235 ]
RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II)
Molluscum Contagiosum Virus Subtype 1 (MOCV) (MCVI)
Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Molluscipoxvirus> Molluscum Contagiosum Virus> Molluscum Contagiosum Virus Subtype 1 (MOCV) (MCVI)
Various pathway(s) in which protein is involved
Not Available
MKNLPGVFAFPDNETIFAHAYSQRELEAMLPARAGAQPHAFAYAAWPLSKHRWRGAFVCRQRGVLKLNLELDAGAFERVPRSEAERFEPEQSDARALMHR
GADGTVMSFECYSFLRCRPGLELREAGLALLRGLVVGGNRMRIFSGVRRAGASAATSAGMLGNESPFERAPFASLRIDAQAALFRAWAARRPTVVTGGTG
VGKTSQVPKLLLWFNYLFGGTEDLDVLAPARERPVVLSLPRVALVRMNGHALRRALGFDALEGSPVELRYGDLAPADANSSRSPFRLVVSTNQLTLGALF
AHGTVILDEVHEHDQMADIMLAVLRVHRARVDSIVLMSATLEDDRERLQEFFPDAEFVHIPGSTRFEIRGVYVRNSSDPRDARAYDEEERRNVSAALSAH
RPRAGRCGILFVASVAQCEDYARLLTREHPELGVYVVHGKTPNVDALLAEVYASARPCVLVSTPYLESSVTIRTVTHVYDTGRVFVPAPFGGRQMLISPA
MRTQRRGRVGRVMPGTYVYFYDPARLAPIKRIDSEFLYNYIIYARHYGLVLPDDLYVQPSDLELLRRCEEYLDGFGLAPERLFELASTRYLRMVEYAKIY
ARGGARAEELNRFERDGVVTEDVLASIRALNLRARVLSARARRGQFLHTCEVAFGPYAGTRFLLANRRRLRGDIFMVTERSFVL
GADGTVMSFECYSFLRCRPGLELREAGLALLRGLVVGGNRMRIFSGVRRAGASAATSAGMLGNESPFERAPFASLRIDAQAALFRAWAARRPTVVTGGTG
VGKTSQVPKLLLWFNYLFGGTEDLDVLAPARERPVVLSLPRVALVRMNGHALRRALGFDALEGSPVELRYGDLAPADANSSRSPFRLVVSTNQLTLGALF
AHGTVILDEVHEHDQMADIMLAVLRVHRARVDSIVLMSATLEDDRERLQEFFPDAEFVHIPGSTRFEIRGVYVRNSSDPRDARAYDEEERRNVSAALSAH
RPRAGRCGILFVASVAQCEDYARLLTREHPELGVYVVHGKTPNVDALLAEVYASARPCVLVSTPYLESSVTIRTVTHVYDTGRVFVPAPFGGRQMLISPA
MRTQRRGRVGRVMPGTYVYFYDPARLAPIKRIDSEFLYNYIIYARHYGLVLPDDLYVQPSDLELLRRCEEYLDGFGLAPERLFELASTRYLRMVEYAKIY
ARGGARAEELNRFERDGVVTEDVLASIRALNLRARVLSARARRGQFLHTCEVAFGPYAGTRFLLANRRRLRGDIFMVTERSFVL
684
Not Available
Not Available
01-02-1997
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for replication and propagation of viral particles (By similarity).
3.6.4.13
Virion. Note=Localizes to the virion core. .
♦DOMAIN 184 359 Helicase ATP-binding.
♦ DOMAIN 392 563 Helicase C-terminal.
♦ DOMAIN 392 563 Helicase C-terminal.
MOTIF 308 311 DEXH box.
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available