Results | viHumans

UniProt ID

Q8V571

Status

Reviewed

Host

Cynomys Gunnisoni (Gunnison's Prairie Dog) [TaxID: 45479]; Cynomys Leucurus (White-tailed Prairie Dog) [TaxID: 99825]; Cynomys Ludovicianus (Black-tailed Prairie Dog) [TaxID: 45480]; Cynomys Mexicanus (Mexican Prairie Dog) [TaxID: 99826]; Cynomys Parvidens (Utah Prairie Dog) [TaxID: 99827]; Gliridae (dormice) [TaxID: 30650]; Heliosciurus Ruwenzorii (Ruwenzori Sun Squirrel) [TaxID: 226685]; Homo Sapiens (Human) [TaxID: 9606]; Mus Musculus (Mouse) [TaxID: 10090]

Gene Name

P28 D5R[Gene ID: 928906 ]

Protein Name

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein D5R) (RING-type E3 ubiquitin transferase p28-like)

Organism Name

Monkeypox Virus (strain Zaire-96-I-16) (MPX)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Monkeypox Virus> Monkeypox Virus (strain Zaire-96-I-16) (MPX)

RefSeq

NC_003310.1 ; AF380138.1

PubMed ID

11734207

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:928906

Reactome

Not Available

Sequence

							MEFDPVKINTSSIDHVTILQYIDEPNDIRLTVCIIRNINNITYYINITKINPHLANRFRAWKKRIAGRDYMTNLSRDTGIQQSKLTETIRNCQKNKNIYG
LYIHYNLVINVVIDWITDVIVQSILRGLVNWYIANNTYTPNTPNNTTTISELDIIKILDKYEDMYRVSKEKECGICYEVVYSKRLENDRYFGLLDSCNHI
FCITCINIWHRTRRETGALDNCPICRTRFRKITMSKFYKLVN
						

Length

242

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-03-2002

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

RING-finger E3 ubiquitin ligase which catalyzes the formation of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Plays an important role in virulence by acting as an anti-apoptotic factor.

EC

2.3.2.27

Experimentally known GO terms

GO:0016740 ; GO:0016881 ; GO:0030430 ; GO:0039526 ; GO:0039648 ;
GO:0046872

Subcellular Location

Host cytoplasm. Note=Localizes to viral factories, the sites of virus replication. .

Domain(s)

DOMAIN 21 131 KilA-N.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available