Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Pteropus Alecto (Black Flying Fox) [TaxID: 9402]; Pteropus Conspicillatus (Spectacled Flying Fox) [TaxID: 328804]; Pteropus Poliocephalus (Grey-headed Flying Fox) [TaxID: 9403]; Pteropus Scapulatus (Little Red Flying Fox) [TaxID: 94117]; Saccolaimus [TaxID: 446909]
L
♦Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
Australian Bat Lyssavirus (isolate Human/AUS/1998) (ABLV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Rhabdoviridae> Lyssavirus> Australian Bat Lyssavirus> Australian Bat Lyssavirus (isolate Human/AUS/1998) (ABLV)
Various pathway(s) in which protein is involved
Not Available
Not Available
MIDPGEVYDDPIDPVEPEPELKNNTVIPNILRNSDYNLNSPLIEDSARLMLEWLTTGNRPGRLTLTDNCIRSYKTLKCYFRKVDVGSLKVGGLAAQAMIS
LWLHGEHSESNRSRKCLSDLTQFYQKSSPIEKLLNYTLGNRGLRIPPEGVLFCLKKVDYDRAFGRYLANIYASYLFFHVIILYMNALDWDEEKTILALWK
DLSSVDIKKDQVKFRDPIWGSLIVTKDFVYSQNANCLFDRNYTLMLKDLFLSRFNSLLILLSPPEPRYSDDLISQLCQLYIAGDNVLSMCGNSGYDVIKM
LEPYVVNSLVQRAEGFRPLIHSLGDFPLFIRDKVGQLEGTFGPSARKFFQVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLSKLYDQVHIKKVIDGTYQ
ECLASDLAKRVLRWGFDKYSKWYLDPKLLAQDHPLTPYIRTQTWPPKHIVDLVGNTWHRLPITQIFEIPESMDPSEILDDKSHSLTRTKLASWLAENRGG
PVPSEKVIITALSKPPVNPREFLKSIDLGGLPDDDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRV
TGQGLQDYSRVTYAFHLDYEKWNNHQRLESTKDVFSVLDQVFGLKKVFSRTHEFFQKSWVYYSDRSDLIGLWEDQIYCLDMSDGPTCWNGQDGGLEGLRQ
KGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSSGLSQEGLLYELESISRNALSIYRAIEDGASKLGLIIKKEETMCSYDFLIYGKTPLFRGN
ILVPESKRWARVSCISNDQIVNLANIMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSADGDDFLLAMSRIIYLDPSLGG
VSGMSLGRFHIRQFSDPVSEGLSFWKEIWSSSSEPWIHSLCQEAGNPDLGDRSLESFTRLLEDPTTLNIRGGASPTILLKDAIRKALYDEVDKVENSEFR
EAILLSKTHRDNFILFLKSIEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRRSLSRSLEESFYNSEIHGINRMTQVPQRIGRVWSCSSERADL
LREISWGRKVVGTTVPHPSEMLTLLPKSSISCVCGPTGSENPRVSVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESIN
WFIARDSNLAQTLIKNIISLTGPQFPLEEAPVFKRTGSALHRFKSARYSEGGYSSICPNLLSHISVSTDTMSDLTQDGRNFDFMFQPLMLYAQTWTSELV
QKDIRLKDSTFHWHLRCQKCIRSIDDITLDTSQVFEFPDVSKRISRMVSGAVPQFQKLPEVYLKPGHFDSLCGKDKSRHIGSAQGLLYSILVATHDPGYN
DGTIFPVNIYSKISPKDYLRGLARGVLIGSSICFLTRMTNININRPLELISGVISYILLRLDNHPSLYVMLRESSLRSEIFSIPQKIPAAYPTTMKEGNR
SVLCYLQHVLRYERDIITSSPENDWLWIFSDFRSTKMTYLTLITYQSHILLQRIERSLSKKMRADLRQLSSLMRQVLGGHGEDSLDSGEDIQRLLRDALQ
RTRWVDQEVRHAAKTMTGDHSPSKKTSRKAGCSEWICSAQQVAISTSSNPAPVSEMDIRTLSRKLQNPLISGLRVVQWATGAHYKLKPILDDLNAYPSFC
LVVGDGSGGISRTVLNMFPDAKLVFNSLLEVSDLMASGTHPLPPSAIMSGGDDIVSRVVDFESIWEKPSDLRNLSTWRYFQSVQSKLNMSYDLIICDAEV
TDIISVNKITLLMSDFVLSIDGPLDLIFKSYGTMLVNPDYKAIQHLSRAFPKATGYITQLTSSFSSELYLRFSKRGKFFRDVEYLTSSTLREMSLVLFNC
SSPKSELQRARSLNYQDLIRGFPEEIVSNPYNEMIITLIDSEVESFLVHKMVDDLELQRGTLSKMSIIIAIVIVYSNRVFNVSKPLSDPVFYPPSDPKIL
RHFNICCSTMLYLSTILGDVPNFARLHELYNSPITYYFKKQIIRGSIYLSWSWSDDTSVFKRVSCNSNLSLSSHWIRLIYKIIKTTRFTGSHVDLSKEVE
KHLKGYNRWITFNDVRSRSSLLDYSCL
LWLHGEHSESNRSRKCLSDLTQFYQKSSPIEKLLNYTLGNRGLRIPPEGVLFCLKKVDYDRAFGRYLANIYASYLFFHVIILYMNALDWDEEKTILALWK
DLSSVDIKKDQVKFRDPIWGSLIVTKDFVYSQNANCLFDRNYTLMLKDLFLSRFNSLLILLSPPEPRYSDDLISQLCQLYIAGDNVLSMCGNSGYDVIKM
LEPYVVNSLVQRAEGFRPLIHSLGDFPLFIRDKVGQLEGTFGPSARKFFQVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLSKLYDQVHIKKVIDGTYQ
ECLASDLAKRVLRWGFDKYSKWYLDPKLLAQDHPLTPYIRTQTWPPKHIVDLVGNTWHRLPITQIFEIPESMDPSEILDDKSHSLTRTKLASWLAENRGG
PVPSEKVIITALSKPPVNPREFLKSIDLGGLPDDDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRV
TGQGLQDYSRVTYAFHLDYEKWNNHQRLESTKDVFSVLDQVFGLKKVFSRTHEFFQKSWVYYSDRSDLIGLWEDQIYCLDMSDGPTCWNGQDGGLEGLRQ
KGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSSGLSQEGLLYELESISRNALSIYRAIEDGASKLGLIIKKEETMCSYDFLIYGKTPLFRGN
ILVPESKRWARVSCISNDQIVNLANIMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSADGDDFLLAMSRIIYLDPSLGG
VSGMSLGRFHIRQFSDPVSEGLSFWKEIWSSSSEPWIHSLCQEAGNPDLGDRSLESFTRLLEDPTTLNIRGGASPTILLKDAIRKALYDEVDKVENSEFR
EAILLSKTHRDNFILFLKSIEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRRSLSRSLEESFYNSEIHGINRMTQVPQRIGRVWSCSSERADL
LREISWGRKVVGTTVPHPSEMLTLLPKSSISCVCGPTGSENPRVSVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESIN
WFIARDSNLAQTLIKNIISLTGPQFPLEEAPVFKRTGSALHRFKSARYSEGGYSSICPNLLSHISVSTDTMSDLTQDGRNFDFMFQPLMLYAQTWTSELV
QKDIRLKDSTFHWHLRCQKCIRSIDDITLDTSQVFEFPDVSKRISRMVSGAVPQFQKLPEVYLKPGHFDSLCGKDKSRHIGSAQGLLYSILVATHDPGYN
DGTIFPVNIYSKISPKDYLRGLARGVLIGSSICFLTRMTNININRPLELISGVISYILLRLDNHPSLYVMLRESSLRSEIFSIPQKIPAAYPTTMKEGNR
SVLCYLQHVLRYERDIITSSPENDWLWIFSDFRSTKMTYLTLITYQSHILLQRIERSLSKKMRADLRQLSSLMRQVLGGHGEDSLDSGEDIQRLLRDALQ
RTRWVDQEVRHAAKTMTGDHSPSKKTSRKAGCSEWICSAQQVAISTSSNPAPVSEMDIRTLSRKLQNPLISGLRVVQWATGAHYKLKPILDDLNAYPSFC
LVVGDGSGGISRTVLNMFPDAKLVFNSLLEVSDLMASGTHPLPPSAIMSGGDDIVSRVVDFESIWEKPSDLRNLSTWRYFQSVQSKLNMSYDLIICDAEV
TDIISVNKITLLMSDFVLSIDGPLDLIFKSYGTMLVNPDYKAIQHLSRAFPKATGYITQLTSSFSSELYLRFSKRGKFFRDVEYLTSSTLREMSLVLFNC
SSPKSELQRARSLNYQDLIRGFPEEIVSNPYNEMIITLIDSEVESFLVHKMVDDLELQRGTLSKMSIIIAIVIVYSNRVFNVSKPLSDPVFYPPSDPKIL
RHFNICCSTMLYLSTILGDVPNFARLHELYNSPITYYFKKQIIRGSIYLSWSWSDDTSVFKRVSCNSNLSLSSHWIRLIYKIIKTTRFTGSHVDLSKEVE
KHLKGYNRWITFNDVRSRSSLLDYSCL
2127
Not Available
Not Available
01-10-2002
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both acticities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
2.7.7.48 , 2.1.1.56 , 2.7.7.88 , 2.1.1.296
Virion . Host cytoplasm . Note=L and P are packaged asymmetrically towards the blunt end of the virus. .
♦DOMAIN 611 799 RdRp catalytic.
♦ DOMAIN 1674 1871 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1674 1871 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available