Reviewed
Epomops Franqueti (Franquet's Epauleted Fruit Bat) [TaxID: 77231]; Homo Sapiens (Human) [TaxID: 9606]; Myonycteris Torquata (Little Collared Fruit Bat) [TaxID: 77243]; Sus Scrofa (Pig) [TaxID: 9823]
L[Gene ID: 955191 ]
♦RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
Reston Ebolavirus (strain Reston-89) (REBOV) (Reston Ebola Virus)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Filoviridae> Ebolavirus> Reston Ebolavirus> Reston Ebolavirus (strain Reston-89) (REBOV) (Reston Ebola Virus)
Not Available
Various pathway(s) in which protein is involved
Not Available
MATQHTQYPDARLSSPIVLDQCDLVTRACGLYSSYSLNPQLRQCKLPKHIYRLKFDTIVSKFLSDTPVATLPIDYLVPILLRSLTGHGDRPLTPTCNQFL
DEIINYTLHDAAFLDYYLKATGAQDHLTNIATREKLKNEILNNDYVHQLFFWHDLSILARRGRLNRGNNRSTWFVHDEFIDILGYGDYIFWKIPLSLLPV
TIDGVPHAATDWYQPTLFKESILGHSQILSVSTAEILIMCKDIITCRFNTSLIASIAKLEDVDVSDYPDPSDILKIYNAGDYVISILGSEGYKIIKYLEP
LCLAKIQLCSKFTERKGRFLTQMHLSVINDLRELISNRRLKDYQQEKIRDFHKILLQLQLSPQQFCELFSVQKHWGHPILHSEKAIQKVKRHATILKALR
PNVIFETYCVFKYNIAKHYFDSQGTWYSVISDRNLTPGLNSFIKRNHFPSLPMIKDLLWEFYHLNHPPLFSTKVISDLSIFIKDRATAVEQTCWDAVFEP
NVLGYNPPNKFSTKRVPEQFLEQEDFSIESVLNYAQELHYLLPQNRNFSFSLKEKELNIGRTFGKLPYLTRNVQTLCEALLADGLAKAFPSNMMVVTERE
QKESLLHQASWHHTSDDFGENATVRGSSFVTDLEKYNLAFRYEFTAPFIEYCNHCYGVRNVFNWMHYLIPQCYMHVSDYYNPPHNVNLSNREYPPEGPSS
YRGHLGGIEGLQQKLWTSISCAQISLVEIKTGFKLRSAVMGDNQCITVLSVFPLKTDPEEQEQSAEDNAARVAASLAKVTSACGIFLKPDETFVHSGFIY
FGKKQYLNGVQLPQSLKTAARMAPLSDAIFDDLQGTLASIGTAFERAISETRHILPCRIVAAFHTYFAVRILQYHHLGFNKGIDLGQLSLSKPLDYGTIT
LTLAVPQVLGGLSFLNPEKCFYRNFGDPVTSGLFQLRVYLEMVNMKDLFCPLISKNPGNCSAIDFVLNPSGLNVPGSQDLTSFLRQIVRRSITLTARNKL
INTLFHASADLEDEMVCKWLLSSNPVMSRFAADIFSRTPSGKRLQILGYLEGTRTLLASKIINNNSETPVLDKLRKITLQRWNLWFSYLDHCDQLLADAL
QKISCTVDLAQILREYTWSHILEGRSLIGATLPCMVEQFKVKWLGQYEPCPECLNKKGSNAYVSVAVKDQVVSAWPNTSRISWTIGSGVPYIGSRTEDKI
GQPAIKPRCPSSALKEAIELASRLTWVTQGGSNSEQLIRPFLEARVNLSVSEVLQMTPSHYSGNIVHRYNDQYSPHSFMANRMSNTATRLIVSTNTLGEF
SGGGQAARDSNIIFQNVINLAVALYDIRFRNTNTSDIRHNRAHLHLTECCTKEVPAQYLTYTSALNLDLSRYRDNELIYDSNPLKGGLNCNLTIDSPLVK
GPRLNMIEDDLLRFPHLSGWELAKTVVQSIISDNSNSSTDPISSGETRSFTTHFLTYPQIGLLYSFGAVLCFYLGNTILWTKKLDYEQFLYYLHNQLHNL
PHRALRVFKPTFKHASVMSRLMEIDSNFSIYIGGTSGDRGLSDAARLFLRTAIASFLQFLKSWIIDRQKTIPLWIVYPLEGQQPESINEFLHKILGLLKQ
GPKSIPKEVSIQNDGHLDLAENNYVYNSKSTASNFFHASLAYWRSRKSRKTQDHNDFSRGDGTLTEPVRKFSSNHQSDEKYYNVTCGKSPKPQERKDFSQ
YRLSNNGQTMSNHRKKGKFHKWNPCKMLMESQRGTVLTEGDYFQNNTPPTDDVSSPHRLILPFFKLGNHNHAHDQDAQELMNQNIKQYLHQLRSMLDTTI
YCRFTGIVSSMHYKLDEVLLEYNSFDSAITLAEGEGSGALLLLQKYSTRLLFLNTLATEHSIESEVVSGFSTPRMLLPIMQKVHEGQVTVILNNSASQIT
DITSSMWLSNQKYNLPCQVEIIMMDAETTENLNRSQLYRAVYNLILDHIDPQYLKVVVLKVFLSDIEGILWINDYLAPLFGAGYLIKPITSSARSSEWYL
CLSNLISTNRRSAHQTHKACLGVIRDALQAQVQRGVYWLSHIAQYATKNLHCEYIGLGFPSLEKVLYHRYNLVDTGLGPLSSVIRHLTNLQAEIRDLVLD
YNLMRESRTQTYHFIKTAKGRITKLVNDFLKFSLIVQALKNNSSWYTELKKLPEVINVCNRFYHTHNCECQEKFFVQTLYLQRLRDAEIKLIERLTGLMR
FYPEGLIYSNHT
DEIINYTLHDAAFLDYYLKATGAQDHLTNIATREKLKNEILNNDYVHQLFFWHDLSILARRGRLNRGNNRSTWFVHDEFIDILGYGDYIFWKIPLSLLPV
TIDGVPHAATDWYQPTLFKESILGHSQILSVSTAEILIMCKDIITCRFNTSLIASIAKLEDVDVSDYPDPSDILKIYNAGDYVISILGSEGYKIIKYLEP
LCLAKIQLCSKFTERKGRFLTQMHLSVINDLRELISNRRLKDYQQEKIRDFHKILLQLQLSPQQFCELFSVQKHWGHPILHSEKAIQKVKRHATILKALR
PNVIFETYCVFKYNIAKHYFDSQGTWYSVISDRNLTPGLNSFIKRNHFPSLPMIKDLLWEFYHLNHPPLFSTKVISDLSIFIKDRATAVEQTCWDAVFEP
NVLGYNPPNKFSTKRVPEQFLEQEDFSIESVLNYAQELHYLLPQNRNFSFSLKEKELNIGRTFGKLPYLTRNVQTLCEALLADGLAKAFPSNMMVVTERE
QKESLLHQASWHHTSDDFGENATVRGSSFVTDLEKYNLAFRYEFTAPFIEYCNHCYGVRNVFNWMHYLIPQCYMHVSDYYNPPHNVNLSNREYPPEGPSS
YRGHLGGIEGLQQKLWTSISCAQISLVEIKTGFKLRSAVMGDNQCITVLSVFPLKTDPEEQEQSAEDNAARVAASLAKVTSACGIFLKPDETFVHSGFIY
FGKKQYLNGVQLPQSLKTAARMAPLSDAIFDDLQGTLASIGTAFERAISETRHILPCRIVAAFHTYFAVRILQYHHLGFNKGIDLGQLSLSKPLDYGTIT
LTLAVPQVLGGLSFLNPEKCFYRNFGDPVTSGLFQLRVYLEMVNMKDLFCPLISKNPGNCSAIDFVLNPSGLNVPGSQDLTSFLRQIVRRSITLTARNKL
INTLFHASADLEDEMVCKWLLSSNPVMSRFAADIFSRTPSGKRLQILGYLEGTRTLLASKIINNNSETPVLDKLRKITLQRWNLWFSYLDHCDQLLADAL
QKISCTVDLAQILREYTWSHILEGRSLIGATLPCMVEQFKVKWLGQYEPCPECLNKKGSNAYVSVAVKDQVVSAWPNTSRISWTIGSGVPYIGSRTEDKI
GQPAIKPRCPSSALKEAIELASRLTWVTQGGSNSEQLIRPFLEARVNLSVSEVLQMTPSHYSGNIVHRYNDQYSPHSFMANRMSNTATRLIVSTNTLGEF
SGGGQAARDSNIIFQNVINLAVALYDIRFRNTNTSDIRHNRAHLHLTECCTKEVPAQYLTYTSALNLDLSRYRDNELIYDSNPLKGGLNCNLTIDSPLVK
GPRLNMIEDDLLRFPHLSGWELAKTVVQSIISDNSNSSTDPISSGETRSFTTHFLTYPQIGLLYSFGAVLCFYLGNTILWTKKLDYEQFLYYLHNQLHNL
PHRALRVFKPTFKHASVMSRLMEIDSNFSIYIGGTSGDRGLSDAARLFLRTAIASFLQFLKSWIIDRQKTIPLWIVYPLEGQQPESINEFLHKILGLLKQ
GPKSIPKEVSIQNDGHLDLAENNYVYNSKSTASNFFHASLAYWRSRKSRKTQDHNDFSRGDGTLTEPVRKFSSNHQSDEKYYNVTCGKSPKPQERKDFSQ
YRLSNNGQTMSNHRKKGKFHKWNPCKMLMESQRGTVLTEGDYFQNNTPPTDDVSSPHRLILPFFKLGNHNHAHDQDAQELMNQNIKQYLHQLRSMLDTTI
YCRFTGIVSSMHYKLDEVLLEYNSFDSAITLAEGEGSGALLLLQKYSTRLLFLNTLATEHSIESEVVSGFSTPRMLLPIMQKVHEGQVTVILNNSASQIT
DITSSMWLSNQKYNLPCQVEIIMMDAETTENLNRSQLYRAVYNLILDHIDPQYLKVVVLKVFLSDIEGILWINDYLAPLFGAGYLIKPITSSARSSEWYL
CLSNLISTNRRSAHQTHKACLGVIRDALQAQVQRGVYWLSHIAQYATKNLHCEYIGLGFPSLEKVLYHRYNLVDTGLGPLSSVIRHLTNLQAEIRDLVLD
YNLMRESRTQTYHFIKTAKGRITKLVNDFLKFSLIVQALKNNSSWYTELKKLPEVINVCNRFYHTHNCECQEKFFVQTLYLQRLRDAEIKLIERLTGLMR
FYPEGLIYSNHT
2212
Not Available
Not Available
01-10-2002
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
2.7.7.48 , 2.1.1.56 , 2.7.7.88 , 2.1.1.296
Host cytoplasm. Virion .
♦DOMAIN 625 809 RdRp catalytic.
♦ DOMAIN 1803 2001 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1803 2001 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available