Results | viHumans

UniProt ID

Q8B6J7

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Mammalia [TaxID: 40674]

Gene Name

M

Protein Name

Matrix protein (Phosphoprotein M2)

Organism Name

Rabies Virus (strain HEP-Flury) (RABV)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Rhabdoviridae> Lyssavirus> Rabies Lyssavirus> Rabies Virus (strain HEP-Flury) (RABV)

RefSeq

NC_001542.1 ; M13215.1

PubMed ID

12505638 ; 10338196 ; 14695448

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MNFLCKIVKNCRDEDTQKPSPASAPPDGDDLWLPPPEYVPLKELTSKKNMRNFCINGEVKVCSPNGYSFRILRHILRSFDEIYSGNHRMIGLVKVVVGLA
LSGAPAPEGMNWVYKLRRTLIFQWADSRGPLEGEELEHSQEITWDDDTEFVGLQMRVSARQCHIQGRIWCIDMNSRACQLWSDMSLQTQRSEEDKDSSLL
LE
						

Length

202

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-03-2003

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0019031 ; GO:0033645 ; GO:0039660 ; GO:0039702 ; GO:0055036

Subcellular Location

♦ Virion membrane
♦ Peripheral membrane protein . Host endomembrane system
♦ Peripheral membrane protein .

Domain(s)

Not Available

Motif(s)

MOTIF 35 38 PPXY motif.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available