Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Mammalia [TaxID: 40674]
L
♦Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
Rabies Virus (strain HEP-Flury) (RABV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Rhabdoviridae> Lyssavirus> Rabies Lyssavirus> Rabies Virus (strain HEP-Flury) (RABV)
Various pathway(s) in which protein is involved
Not Available
Not Available
MLDPGEVYDDPIDPIESEAEPRGTPTVPNILRNSDYNLNSPLIEDSAKLMLEWLKTGNRPYRMTLTDNCSRSYKDLKDYFKKVDLGSLKVGGTAAQSMIS
LWLYGAHSESNRSRRCITDLAHFYSKSSPIEKLLNCTLGNRGLRIPPEGVLSCLERVDYDKAFGRYLANTYSSYLFFHVITLYMNALDWEEEKTILALWK
DLTSVDTGKDLVKFKDQIWGLLIVTKDFVYSQSSNCLFDRNYTLMLKDLFLSRFNSLMILLSPPEPRYSDDLISQLCQLYIAGDQVLSLCGNSGYEVIKI
LEPYVVNSLVQRAEKFRPLIHSLGDFPMFIKDKVNQLEGTFGPSAKRFFRVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLLKLYDQVHIKKVIDKSYQ
ECLASDLARRILRWGFDKYSKWYLDSRFLARDHPLAPYIKTQTWPPKHIVDLVGDTWHKLPITQIFEIPESMDPSEILDDKSHSFTRTRLASWLSENRGG
PVPSEKVIITALSQPPVNPREFLKSIDLGGLPDDDLIIGLRPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRV
TGQGLLDYSRVTYAFHLDYEKWNNHQRLESTEDVFSVLDQVFGLKRVFSRTHEFFQKSWIYYSDRSDLIGLREDQIYCLDMSNGPTCWNGQDGGLEGLRQ
KGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSPGLSQEGLLYELESISRNALSIYRAIEEGASKLGLIIKKEETMCSYDFLIYGKTPLFRGN
ILVPESKRWARVSCISNDQIVNLANIMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSAEGESFLLAMSRIIYLDPSLGG
VSGMSLGRFHIRQFSDPVSEGLSFWREIWLSSHESWIHALCQEAGNPDLGERTLESFTRLLEDPTTLNIKGGASPTILLKDAIRKALYDEVDKVENSEFR
EAILLSKTHRDNFILFLKSVEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRKSLSRTLEESFYNSEIHGINRMTQTPQRVGRVWPCSSERADL
LREISWGRKVVGTTVPHPSEMLGLLPKSSISCTCGATGGGNPRVSVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRAISLKESIN
WFINRNSNLAQTLIRNIMSLTGPDFSLEEAPVFKRTGSALHRFKSARYSEGGYSSVCPNLLSHISVSTDTMSDLTQDGKNYDFMFQPLMLYAQTWTSELV
QRDTRLRDSTFHWHLRCNRCVRPIEDITLETSQIFEFPDVSKRISRMVSGAVPHFQKLPDIRLRPGDFESLSGREKSRHIGSAQGLLYSILVAIHDSGYN
DGTIFPVNIYGKVSPRDYLRGLARGILIGSSICFLTRMTNINIKRPLELISGVISYILLRLDNHPSLYIMLREPSLRGEIFSIPQKIPAAYPTTMKEGNR
SILCYLQHVLRYEREVITASPENDWLWIFSDFRSAKMTYLTLITYQSHLLLQRVERNLSKSMRATLQQMGSLMRQVLGGHGEDTLESDDDIQRLLKDSLR
RTRWVDQEVRHAARTMSGDYSPNKRVSRKAGCSEWVCSAQQVAVSTSANPAPVSELDIRALSKRFQNPLISGLRVVQWATGAHYKLKPILDDLNVFPSLC
LVVGDGSGGISRAVLNMFPDSKLVFNSLLEVNDLMASGTRPLPPSAIMSGGDDIISRVIDFDSIWEKPSDLRNLATWRYFQSVQKQVNMSYDLIICDAEV
TDIASINRITLLMSDFALSIDGPLYLVFKTYGTMLVNPDYKAIQHLSRAFPSVTGFITQVTSSFSSELYLRFSKRGKFFRDAEYLTSSTLREMSLVLFNC
SSPKSEMQRARSLNYQDLVRGFPEEIISNPYNEMIITLIDSDVESFLVHKMVDDLELQRGTLSKVAIIISIMIVFSNRVFNISKPLTDPLFYPPSDPKIL
RHFNICCSTMMYLSTALGDVPSFARLHDLYNRPITYYFRKQVIRGNIYLSWSWSDDTPVFKRVACNSSLSLSSHWIRLIYKIVKTTRLVGRIEDLSGEVE
RHLHGYNRWITLEDIRSRSSLLDYSCL
LWLYGAHSESNRSRRCITDLAHFYSKSSPIEKLLNCTLGNRGLRIPPEGVLSCLERVDYDKAFGRYLANTYSSYLFFHVITLYMNALDWEEEKTILALWK
DLTSVDTGKDLVKFKDQIWGLLIVTKDFVYSQSSNCLFDRNYTLMLKDLFLSRFNSLMILLSPPEPRYSDDLISQLCQLYIAGDQVLSLCGNSGYEVIKI
LEPYVVNSLVQRAEKFRPLIHSLGDFPMFIKDKVNQLEGTFGPSAKRFFRVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLLKLYDQVHIKKVIDKSYQ
ECLASDLARRILRWGFDKYSKWYLDSRFLARDHPLAPYIKTQTWPPKHIVDLVGDTWHKLPITQIFEIPESMDPSEILDDKSHSFTRTRLASWLSENRGG
PVPSEKVIITALSQPPVNPREFLKSIDLGGLPDDDLIIGLRPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRV
TGQGLLDYSRVTYAFHLDYEKWNNHQRLESTEDVFSVLDQVFGLKRVFSRTHEFFQKSWIYYSDRSDLIGLREDQIYCLDMSNGPTCWNGQDGGLEGLRQ
KGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSPGLSQEGLLYELESISRNALSIYRAIEEGASKLGLIIKKEETMCSYDFLIYGKTPLFRGN
ILVPESKRWARVSCISNDQIVNLANIMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSAEGESFLLAMSRIIYLDPSLGG
VSGMSLGRFHIRQFSDPVSEGLSFWREIWLSSHESWIHALCQEAGNPDLGERTLESFTRLLEDPTTLNIKGGASPTILLKDAIRKALYDEVDKVENSEFR
EAILLSKTHRDNFILFLKSVEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRKSLSRTLEESFYNSEIHGINRMTQTPQRVGRVWPCSSERADL
LREISWGRKVVGTTVPHPSEMLGLLPKSSISCTCGATGGGNPRVSVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRAISLKESIN
WFINRNSNLAQTLIRNIMSLTGPDFSLEEAPVFKRTGSALHRFKSARYSEGGYSSVCPNLLSHISVSTDTMSDLTQDGKNYDFMFQPLMLYAQTWTSELV
QRDTRLRDSTFHWHLRCNRCVRPIEDITLETSQIFEFPDVSKRISRMVSGAVPHFQKLPDIRLRPGDFESLSGREKSRHIGSAQGLLYSILVAIHDSGYN
DGTIFPVNIYGKVSPRDYLRGLARGILIGSSICFLTRMTNINIKRPLELISGVISYILLRLDNHPSLYIMLREPSLRGEIFSIPQKIPAAYPTTMKEGNR
SILCYLQHVLRYEREVITASPENDWLWIFSDFRSAKMTYLTLITYQSHLLLQRVERNLSKSMRATLQQMGSLMRQVLGGHGEDTLESDDDIQRLLKDSLR
RTRWVDQEVRHAARTMSGDYSPNKRVSRKAGCSEWVCSAQQVAVSTSANPAPVSELDIRALSKRFQNPLISGLRVVQWATGAHYKLKPILDDLNVFPSLC
LVVGDGSGGISRAVLNMFPDSKLVFNSLLEVNDLMASGTRPLPPSAIMSGGDDIISRVIDFDSIWEKPSDLRNLATWRYFQSVQKQVNMSYDLIICDAEV
TDIASINRITLLMSDFALSIDGPLYLVFKTYGTMLVNPDYKAIQHLSRAFPSVTGFITQVTSSFSSELYLRFSKRGKFFRDAEYLTSSTLREMSLVLFNC
SSPKSEMQRARSLNYQDLVRGFPEEIISNPYNEMIITLIDSDVESFLVHKMVDDLELQRGTLSKVAIIISIMIVFSNRVFNISKPLTDPLFYPPSDPKIL
RHFNICCSTMMYLSTALGDVPSFARLHDLYNRPITYYFRKQVIRGNIYLSWSWSDDTPVFKRVACNSSLSLSSHWIRLIYKIVKTTRLVGRIEDLSGEVE
RHLHGYNRWITLEDIRSRSSLLDYSCL
2127
Not Available
Not Available
01-03-2003
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both acticities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
2.7.7.48 , 2.1.1.56 , 2.7.7.88 , 2.1.1.296
Virion . Host cytoplasm . Note=L and P are packaged asymmetrically towards the blunt end of the virus. .
♦DOMAIN 611 799 RdRp catalytic.
♦ DOMAIN 1674 1871 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1674 1871 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available