Reviewed
Canis Lupus Familiaris (Dog) (Canis Familiaris) [TaxID: 9615]; Homo Sapiens (Human) [TaxID: 9606]
L[Gene ID: 3160798 ]
♦RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
Parainfluenza Virus 5 (strain W3) (PIV5) (Simian Virus 5)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Paramyxoviridae> Rubulavirus> Mammalian Rubulavirus 5> Parainfluenza Virus 5 (strain W3) (PIV5) (Simian Virus 5)
Not Available
Various pathway(s) in which protein is involved
Not Available
MAGSREILLPEVHLNSPIVKHKLYYYILLGNLPNEIDLDDLGPLHNQNWNQIAHEESNLAQRLVNVRNFLITHIPDLRKGHWQEYVNVILWPRILPLIPD
FKINDQLPLLKNWDKLVKESCSVINAGTSQCIQNLSYGLTGRGNLFTRSRELSGDRRDIDLKTVVAAWHDSDWKRISDFWIMIKFQMRQLIVRQTDHNDS
DLITYIENREGIIIITPELVALFNTENHTLTYMTFEIVLMVSDMYEGRHNILSLCTVSTYLNPLKKRITYLLSLVDNLAFQIGDAVYNIIALLESFVYAQ
LQMSDPIPELRGQFHAFVCSEILDALRGTNSFTQDELRTVTTNLISPFQDLTPDLTAELLCIMRLWGHPMLTASQAAGKVRESMCAGKVLDFPTIMKTLA
FFHTILINGYRRKHHGVWPPLNLPGNASKGLTELMNDNTEISYEFTLKHWKEVSLIKFKKCFDADAGEELSIFMKDKAISAPKQDWMSVFRRSLIKQRHQ
HHQVPLPNPFNRRLLLNFLGDDKFDPNVELQYVTSGEYLHDDTFCASYSLKEKEIKPDGRIFAKLTKRMRSCQVIAESLLANHAGKLMKENGVVMNQLSL
TKSLLTMSQIGIISEKARKSTRDNINQPGFQNIQRNKSHHSKQVNQRDPSDDFELAASFLTTDLKKYCLQWRYQTIIPFAQSLNRMYGYPHLFEWIHLRL
MRSTLYVGDPFNPPADTSQFDLDKVINGDIFIVSPRGGIEGLCQKAWTMISIAVIILSATESGTRVMSMVQGDNQAIAVTTRVPRSLPTLEKKTIAFRSC
NLFFERLKCNNFGLGHHLKEQETIISSHFFVYSKRIFYQGRILTQALKNASKLCLTADVLGECTQSSCSNLATTVMRLTENGVEKDICFYLNIYMTIKQL
SYDIIFPQVSIPGDQITLEYINNPHLVSRLALLPSQLGGLNYLSCSRLFNRNIGDPVVSAVADLKRLIKSGCMDYWILYNLLGRKPGNGSWATLAADPYS
INIEYQYPPTTALKRHTQQALMELSTNPMLRGIFSDNAQAEENNLARFLLDREVIFPRVAHIIIEQTSVGRRKQIQGYLDSTRSIMRKSLEIKPLSNRKL
NEILDYNINYLAYNLALLKNAIEPPTYLKAMTLETCSIDIARNLRKLSWAPLLGGRNLEGLETPDPIEITAGALIVGSGYCEQCAAGDNRFTWFFLPSGI
EIGGDPRDNPPIRVPYIGSRTDERRVASMAYIRGASSSLKAVLRLAGVYIWAFGDTLENWIDALDLSHTRVNITLEQLQSLTPLPTSANLTHRLDDGTTT
LKFTPASSYTFSSFTHISNDEQYLTINDKTADSNIIYQQLMITGLGILETWNNPPINRTFEESTLHLHTGASCCVRPVDSCILSEALTVKPHITVPYSNK
FVFDEDPLSEYETAKLESLSFQAQLGNIDAVDMTGKLTLLSQFTARQIINAITGLDESVSLTNDAIVASDYVSNWISECMYTKLDELFMYCGWELLLELS
YQMYYLRVVGWSNIVDYSYMILRRIPGAALNNLASTLSHPKLFRRAINLDIVAPLNAPHFASLDYIKMSVDAILWGCKRVINVLSNGGDLELVVTSEDSL
ILSDRSMNLIARKLTLLSLIHHNGLELPKIKGFSPDEKCFALTEFLRKVVNSGLSSIENLSNFMYNVENPRLAAFASNNYYLTRKLLNSIRDTESGQVAV
TSYYESLEYIDSLKLTPHVPGTSCIEDDSLCTNDYIIWIIESNANLEKYPIPNSPEDDSNFHNFKLNAPSHHTLRPLGLSSTAWYKGISCCRYLERLKLP
QGDHLYIAEGSGASMTIIEYLFPGRKIYYNSLFSSGDNPPQRNYAPMPTQFIESVPYKLWQAHTDQYPEIFEDFIPLWNGNAAMTDIGMTACVEFIINRV
GPRTCSLVHVDLESSASLNQQCLSKPIINAIITATTVLCPHGVLILKYSWLPFTRFSTLITFLWCYFERITVLRSTYSDPANHEVYLICILANNFAFQTV
SQATGMAMTLTDQGFTLISPERINQYWDGHLKQERIVAEAIDKVVLGENALFNSSDNELILKCGGTPNARNLIDIEPVATFIEFEQLICTMLTTHLKEII
DITRSGTQDYESLLLTPYNLGLLGKISTIVRLLTERILNHTIRNWLILPPSLRMIVKQDLEFGIFRITSILNSDRFLKLSPNRKYLIAQLTAGYIRKLIE
GDCNIDLTRPIQKQIWKALGCVVYCHDPMDQRESTEFIDININEEIDRGIDGEEI
FKINDQLPLLKNWDKLVKESCSVINAGTSQCIQNLSYGLTGRGNLFTRSRELSGDRRDIDLKTVVAAWHDSDWKRISDFWIMIKFQMRQLIVRQTDHNDS
DLITYIENREGIIIITPELVALFNTENHTLTYMTFEIVLMVSDMYEGRHNILSLCTVSTYLNPLKKRITYLLSLVDNLAFQIGDAVYNIIALLESFVYAQ
LQMSDPIPELRGQFHAFVCSEILDALRGTNSFTQDELRTVTTNLISPFQDLTPDLTAELLCIMRLWGHPMLTASQAAGKVRESMCAGKVLDFPTIMKTLA
FFHTILINGYRRKHHGVWPPLNLPGNASKGLTELMNDNTEISYEFTLKHWKEVSLIKFKKCFDADAGEELSIFMKDKAISAPKQDWMSVFRRSLIKQRHQ
HHQVPLPNPFNRRLLLNFLGDDKFDPNVELQYVTSGEYLHDDTFCASYSLKEKEIKPDGRIFAKLTKRMRSCQVIAESLLANHAGKLMKENGVVMNQLSL
TKSLLTMSQIGIISEKARKSTRDNINQPGFQNIQRNKSHHSKQVNQRDPSDDFELAASFLTTDLKKYCLQWRYQTIIPFAQSLNRMYGYPHLFEWIHLRL
MRSTLYVGDPFNPPADTSQFDLDKVINGDIFIVSPRGGIEGLCQKAWTMISIAVIILSATESGTRVMSMVQGDNQAIAVTTRVPRSLPTLEKKTIAFRSC
NLFFERLKCNNFGLGHHLKEQETIISSHFFVYSKRIFYQGRILTQALKNASKLCLTADVLGECTQSSCSNLATTVMRLTENGVEKDICFYLNIYMTIKQL
SYDIIFPQVSIPGDQITLEYINNPHLVSRLALLPSQLGGLNYLSCSRLFNRNIGDPVVSAVADLKRLIKSGCMDYWILYNLLGRKPGNGSWATLAADPYS
INIEYQYPPTTALKRHTQQALMELSTNPMLRGIFSDNAQAEENNLARFLLDREVIFPRVAHIIIEQTSVGRRKQIQGYLDSTRSIMRKSLEIKPLSNRKL
NEILDYNINYLAYNLALLKNAIEPPTYLKAMTLETCSIDIARNLRKLSWAPLLGGRNLEGLETPDPIEITAGALIVGSGYCEQCAAGDNRFTWFFLPSGI
EIGGDPRDNPPIRVPYIGSRTDERRVASMAYIRGASSSLKAVLRLAGVYIWAFGDTLENWIDALDLSHTRVNITLEQLQSLTPLPTSANLTHRLDDGTTT
LKFTPASSYTFSSFTHISNDEQYLTINDKTADSNIIYQQLMITGLGILETWNNPPINRTFEESTLHLHTGASCCVRPVDSCILSEALTVKPHITVPYSNK
FVFDEDPLSEYETAKLESLSFQAQLGNIDAVDMTGKLTLLSQFTARQIINAITGLDESVSLTNDAIVASDYVSNWISECMYTKLDELFMYCGWELLLELS
YQMYYLRVVGWSNIVDYSYMILRRIPGAALNNLASTLSHPKLFRRAINLDIVAPLNAPHFASLDYIKMSVDAILWGCKRVINVLSNGGDLELVVTSEDSL
ILSDRSMNLIARKLTLLSLIHHNGLELPKIKGFSPDEKCFALTEFLRKVVNSGLSSIENLSNFMYNVENPRLAAFASNNYYLTRKLLNSIRDTESGQVAV
TSYYESLEYIDSLKLTPHVPGTSCIEDDSLCTNDYIIWIIESNANLEKYPIPNSPEDDSNFHNFKLNAPSHHTLRPLGLSSTAWYKGISCCRYLERLKLP
QGDHLYIAEGSGASMTIIEYLFPGRKIYYNSLFSSGDNPPQRNYAPMPTQFIESVPYKLWQAHTDQYPEIFEDFIPLWNGNAAMTDIGMTACVEFIINRV
GPRTCSLVHVDLESSASLNQQCLSKPIINAIITATTVLCPHGVLILKYSWLPFTRFSTLITFLWCYFERITVLRSTYSDPANHEVYLICILANNFAFQTV
SQATGMAMTLTDQGFTLISPERINQYWDGHLKQERIVAEAIDKVVLGENALFNSSDNELILKCGGTPNARNLIDIEPVATFIEFEQLICTMLTTHLKEII
DITRSGTQDYESLLLTPYNLGLLGKISTIVRLLTERILNHTIRNWLILPPSLRMIVKQDLEFGIFRITSILNSDRFLKLSPNRKYLIAQLTAGYIRKLIE
GDCNIDLTRPIQKQIWKALGCVVYCHDPMDQRESTEFIDININEEIDRGIDGEEI
2255
Not Available
Not Available
01-11-1996
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
2.7.7.48 , 2.1.1.56 , 2.7.7.88 , 2.1.1.296
Virion . Host cytoplasm .
♦DOMAIN 656 840 RdRp catalytic.
♦ DOMAIN 1775 1988 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1775 1988 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available