Results | viHumans

UniProt ID

Q85365

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

C5L

Protein Name

Apoptosis regulator Bcl-2 homolog (vBcl-2)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8264798 ; 25766319

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MYNSMLPMFMCNNIVDDIDDIDDIDDIDDIDDIDDIDDKASNNDDHNYVYPLPENMVYRFNKSTNILDYLSTERDHVMMAVQYYMSKQRLDDLYRQLPTK
TRSYIDIINMYCDKVNNDYNRDMNIMYDMASTESFTVYDINNEVNTILMDNKGLGVRLATISFITELGKRCMNPVETIKMFTLLSHTICDDCFIDYITDI
SPPDNTIPNISTREYLKLIGITAIMFATYKTLKYMIG
						

Length

237

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1996

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host apoptosis. Interacts with host BAX and thereby inhibits its activity.

EC

Not Available

Experimentally known GO terms

GO:0019050

Subcellular Location

Not Available

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (2)

Experimetally known structure

5AJJ 5AJK

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available