Results | viHumans

UniProt ID

Q84173

Status

Reviewed

Host

Capra Hircus (Goat) [TaxID: 9925]; Homo Sapiens (Human) [TaxID: 9606]; Ovis Aries (Sheep) [TaxID: 9940]

Gene Name

POL

Protein Name

DNA polymerase (EC 2.7.7.7)

Organism Name

Orf Virus (strain NZ2) (OV NZ-2)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Parapoxvirus> Orf Virus (ORFV)> Orf Virus (strain NZ2) (OV NZ-2)

RefSeq

NC_005336.1 ; AY386264.1

PubMed ID

8758000

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MELKCLNWFENRGNDSRFLFLKARRADNAVVYLRFVQHFYYVVRADAVADIAQPLAWTRALGPMSVVSIDEIVARSAKIPERQRSEIELCLVASERKLAP
PEVFMSDFLNVSWFFVAHDIDPDGCYRVDPALLRDLGSNCFHCDDPGACFAEKIPRFNVTRSGLFLDIECHFEKKFPSVFKNAVSHISFCVVDKDGAERR
FTLTNSDMLSDADLEEAARREIPVCLDPADVKFDAEVTLCPEVTLLRVAKRLLEMPLDFVVTFNGHNFDLRYLDSRLSLLTGEHIRFRLPDGTETVNFCV
YERTKSSHKGVGGVSSTTFHINNNNGTIYFDLYAFIQRTEKLDSYKLDAISKNAFHCTAVVEDARPDAVRFRGDRSTDADGNAAVFARVLSTGNYVTVDE
RVCRVLHKRVDEDGFTVDLADPAARAPGDRVTLAFGKDDVSLADMYANYSLDVCLDMARYCLHDACLCLYLWSHYGVETKIAAAASTYLLPQSVVFEYRA
STCIKGPLMKLLLENRTVMVRADTKSKFFYEGGRVMAPKQKMHNKHVLIFDYNSLYPNVCIYANLSPETLVGVVVSDNRLDAEVAAVDVRRMFPAPRYIA
VPCEPRSPELVAEVAIFDREAKGIIPMLLRSFLDARAKYKKLMKAAETAVDREIYNSMQYTYKITANSVYGLMGFRNSALFSYASAKSCTAIGRTMIAYL
ERTLDGASVCGTRLSLAAAPDNPLLRDEAFAGRAAELEIDAAVAGERTERVGFRSVYGDTDSVFLEVGASDIAFSRRVGRCLERVINEHVLFANFKVEFE
AVYCNLIMQSKKKYTTIKFAVSDGGGSERVSKGTSETRRDVAPFHKLMIRKYKDMLCRALAEEGSGNVGVEILRSLEDELTFEFEARSMPLDWFLLSRTH
HKNFKSPDNPNVALVTRYNAANAEAIEIGERYFFAYVCEEGPWRRRIANVKSYERVVDKTFRLDKNERIMYEVYFKRLCTEIVNLLDNKAMCTLFFERLF
GSKPVFTG
						

Length

1008

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).

EC

2.7.7.7

Experimentally known GO terms

GO:0000166 ; GO:0003677 ; GO:0003887 ; GO:0006260 ; GO:0039693

Subcellular Location

Not Available

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available