Results | viHumans

UniProt ID

Q83884

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

ORF2[Gene ID: 1491972 ]

Protein Name

Capsid protein VP1 (CP) (p59) [Cleaved into: Soluble capsid protein (Protein 30k) (p30)]

Organism Name

Norwalk Virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Caliciviridae> Norovirus> Norwalk Virus> Norovirus Isolates> Norwalk Virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)

RefSeq

NC_001959.2 ; M87661.2

PubMed ID

8391187 ; 7853506 ; 8794293 ; 9311906 ; 12055602 ; 14557646 ; 12825167 ; 16840313 ; 16168575 ;
10514371

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1491972

Reactome

Not Available

Sequence

							MMMASKDATSSVDGASGAGQLVPEVNASDPLAMDPVAGSSTAVATAGQVNPIDPWIINNFVQAPQGEFTISPNNTPGDVLFDLSLGPHLNPFLLHLSQMY
NGWVGNMRVRIMLAGNAFTAGKIIVSCIPPGFGSHNLTIAQATLFPHVIADVRTLDPIEVPLEDVRNVLFHNNDRNQQTMRLVCMLYTPLRTGGGTGDSF
VVAGRVMTCPSPDFNFLFLVPPTVEQKTRPFTLPNLPLSSLSNSRAPLPISSMGISPDNVQSVQFQNGRCTLDGRLVGTTPVSLSHVAKIRGTSNGTVIN
LTELDGTPFHPFEGPAPIGFPDLGGCDWHINMTQFGHSSQTQYDVDTTPDTFVPHLGSIQANGIGSGNYVGVLSWISPPSHPSGSQVDLWKIPNYGSSIT
EATHLAPSVYPPGFGEVLVFFMSKMPGPGAYNLPCLLPQEYISHLASEQAPTVGEAALLHYVDPDTGRNLGEFKAYPDGFLTCVPNGASSGPQQLPINGV
FVFVSWVSRFYQLKPVGTASSARGRLGLRR
						

Length

530

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

11-07-2006

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

♦Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells.
♦ Soluble capsid protein may play a role in viral immunoevasion.

EC

Not Available

Experimentally known GO terms

GO:0030430 ; GO:0039617 ; GO:0042802

Subcellular Location

Virion. Host cytoplasm.

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (9)

Experimetally known structure

1IHM 2ZL5 2ZL6 2ZL7 3BY1 3BY2 3D26 5KW9 5N7M

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available