Results | viHumans

UniProt ID

Q82446

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

ORF2

Protein Name

♦Capsid polyprotein VP90 [Cleaved into: Capsid polyprotein VP70
♦ Capsid protein VP34
♦ Capsid protein VP27
♦ Capsid protein VP25]

Organism Name

Human Astrovirus-2 (HAstV-2)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Astroviridae> Mamastrovirus> Mamastrovirus 1> Human Astrovirus-2 (HAstV-2)

RefSeq

Not Available

PubMed ID

8497068

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MASKSDKQVTVEVNNNGRNRSKSRARSQSRGRGRSVKITVNSHNKGRRQNGRNKYQSNQRVRKIVNKQLRKQGVTGPKPAICQRATATLGTIGTNTTGAT
EIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVLRISLNPTSTPSSTSWSGLGARKHMDVTVGRNAVFKLRPSDLG
GPRDGWWLTNTNDNASDTLGPSIEIHTLGKTMSSYKNEQFTGGLFLVELASEWCFTGYAANPNLVNLVKSTDHEVNVTFEGSKGTPLIMNVAEHSHFARM
AEQHSSISTTFSRAGGDATSDTVWQVLNTAVSAAELVAPPPFNWLIKGGWWFVKLIAGRTRTGTKQFYVYPSYQDALSNKPALCTGGVTGGVLRTTPVTT
LQFTQMNQPSLGHGEHTATIGSIVQDPSGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSR
DPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKEN
NLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTTLPRISSPPDNPSGRYMESHQQDCDSSDDEDDCENVSEETETEDEEDEDEDDEADR
FDLHSPYSSEPEDSDENNRVTLLSTLINQGMTVERATRITKRAFPTCAEKLKRSVYMDLLASGASPSSAWSNACDEARNVGSNQLAKLSGDRGHAE
						

Length

796

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1996

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0039617 ; GO:0075512

Subcellular Location

Virion .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (2)

Experimetally known structure

5KOU 5KOV

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available