Results | viHumans

UniProt ID

Q80IU4

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Pan Troglodytes (Chimpanzee) [TaxID: 9598]

Gene Name

P

Protein Name

♦Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7)
♦ RNA-directed DNA polymerase (EC 2.7.7.49)
♦ Ribonuclease H (EC 3.1.26.4)]

Organism Name

Hepatitis B Virus Genotype E (isolate Cote D'Ivoire/ABI-212/2003) (HBV-E)

Taxonomic Lineage

Viruses> Retro-transcribing Viruses> Hepadnaviridae> Orthohepadnavirus (mammalian Hepatitis B-type Viruses)> Hepatitis B Virus (HBV)> HBV Genotype E> Hepatitis B Virus Genotype E (isolate Cote D'Ivoire/ABI-212/2003) (HBV-E)

RefSeq

NC_003977.2 ; V01460.1

PubMed ID

17206754

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MPLSYQHFRRILLLDEEAGPLEEELPRLADEDLNRRVAEDLNLQLPNVSIPWTHKVGNFSGLYSSTIPVFNPHWKTPSFPDIHLHQDIINKCEQFVGPLT
VNEKRRLNLVMPARFFPISTKYLPLEKGIKPYYPDNVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELHHGAFLDGPSRMGEESFHHQS
SGIFSRPPVGSSIQSKHQKSRLGPQSQQRPLDRSQQGRSGSIRAGVHSPTRRPFGVEPSGSRHAKNIASRSASCLHQSAVRKAAYPNHSTFERHSSSGHA
VEFHNIPPSSAGSQSKRPVFSCWWLQFRNSEPCSDYCLSHLVNLLEDWGPCTEHGRHHIRIPRTPARVTGGVFLVDKNPHNTAESRLVVDFSQFSRGSSR
VSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSNSRIINHHYGTLPNLHDSCSRNLYVSLMLLFKTFGRKL
HLYSHPIIMGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYTSVTNFLLSLGIHLNPNKTKRWGYSLNFMGYVIG
SWGSLPQEHIRIKIKDCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSPTYKAFLCKQYLNLYPVARQRPGLCQVFADA
TPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGVCRPL
LRLPFQPTTGRTSLYAVSPSVPSHLPDRVHFASPLHVAWRPP
						

Length

842

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-2003

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.

EC

2.7.7.7 , 2.7.7.49 , 3.1.26.4

Experimentally known GO terms

GO:0003677 ; GO:0003887 ; GO:0003964 ; GO:0004523 ; GO:0006260 ;
GO:0039503 ; GO:0046872

Subcellular Location

Not Available

Domain(s)

DOMAIN 356 599 Reverse transcriptase.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available