Results | viHumans

UniProt ID

Q7TLC4

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Macaca Fascicularis (Crab-eating Macaque) (Cynomolgus Monkey) [TaxID: 9541]; Macaca Leonina (Northern Pig-tailed Macaque) (Macaca Nemestrina Leonina) [TaxID: 90387]; Macaca Mulatta (Rhesus Macaque) [TaxID: 9544]; Macaca Nemestrina (Pig-tailed Macaque) [TaxID: 9545]

Gene Name

US12[Gene ID: 3850189 ]

Protein Name

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)

Organism Name

Cercopithecine Herpesvirus 16 (CeHV-16) (Herpesvirus Papio 2)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Simplexvirus> Cercopithecine Herpesvirus 16 (CeHV-16) (Herpesvirus Papio 2)

RefSeq

Not Available

PubMed ID

12771408

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3850189

Reactome

Not Available

Sequence

							MSSLYLAEVDAFLQSPRTRHRTCADLRRELDAYADEERREAAKAIAHPDRPLLAPPSAPPDRSRPAPRGTAHPPAASP
						

Length

78

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-2003

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.

EC

Not Available

Experimentally known GO terms

GO:0030430 ; GO:0039504 ; GO:0042025

Subcellular Location

Host cytoplasm . Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available