Results | viHumans

UniProt ID

Q77NP2

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

GM ORF50[Gene ID: 1487658 ]

Protein Name

Envelope glycoprotein M (gM)

Organism Name

Varicella-zoster Virus (strain Oka Vaccine) (HHV-3) (Human Herpesvirus 3)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Oka Vaccine) (HHV-3) (Human Herpesvirus 3)

RefSeq

NC_001348.1 ; X04370.1

PubMed ID

10720545 ; 12388706 ; 18787000 ; 17977964 ; 20106918

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487658

Reactome

Not Available

Sequence

							MGTQKKGPRSEKVSPYDTTTPEVEALDHQMDTLNWRIWIIQVMMFTLGAVMLLATLIAASSEYTGIPCFYAAVVDYELFNATLDGGVWSGNRGGYSAPVL
FLEPHSVVAFTYYTALTAMAMAVYTLITAAIIHRETKNQRVRQSSGVAWLVVDPTTLFWGLLSLWLLNAVVLLLAYKQIGVAATLYLGHFATSVIFTTYF
CGRGKLDETNIKAVANLRQQSVFLYRLAGPTRAVFVNLMAALMAICILFVSLMLELVVANHLHTGLWSSVSVAMSTFSTLSVVYLIVSELILAHYIHVLI
GPSLGTLVACATLGTAAHSYMDRLYDPISVQSPRLIPTTRGTLACLAVFSVVMLLLRLMRAYVYHRQKRSRFYGAVRRVPERVRGYIRKVKPAHRNSRRT
NYPSQGYGYVYENDSTYETDREDELLYERSNSGWE
						

Length

435

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

05-07-2004

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0044175 ; GO:0044177 ; GO:0044201 ;
GO:0055036

Subcellular Location

♦ Virion membrane
♦ Multi-pass membrane protein . Host Golgi apparatus, host trans-Golgi network . Host endosome membrane
♦ Multi-pass membrane protein . Host nucleus inner membrane
♦ Multi-pass membrane protein . Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available