Reviewed
Homo Sapiens (Human) [TaxID: 9606]
Rev
Protein Rev (Regulator of expression of viral proteins)
Human Immunodeficiency Virus Type 2 Subtype B (isolate UC1) (HIV-2)
Viruses> Retro-transcribing Viruses> Retroviridae> Orthoretrovirinae> Lentivirus> Primate Lentivirus Group> Human Immunodeficiency Virus 2> HIV-2 Subtype B> Human Immunodeficiency Virus Type 2 Subtype B (isolate UC1) (HIV-2)
Various pathway(s) in which protein is involved
Not Available
Not Available
MTTREKDLQKGLRLLHLLHQTNPYPQTPGTASQRRNRRRRWKRRGLQILALADRIRSLSDSPTEEPLDLAVQRLQELTVEDLPNPPTSTPTAQAFTCIPP
VWDQLVPRSNPSSNEGCERDSCEHRKSPMESSQKDSGSNHRDPQEDQTRT
VWDQLVPRSNPSSNEGCERDSCEHRKSPMESSQKDSGSNHRDPQEDQTRT
150
Not Available
Not Available
01-11-1996
Inferred from homology
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
---|---|---|---|---|---|
Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
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Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
Not Available
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm. .
Not Available
MOTIF 33 47 Nuclear localization signal and RNA-binding (RRE). ; MOTIF 69 80 Nuclear export signal and binding to XPO1.
Predicted/Modelled
Not Available
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Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available