Reviewed
Homo Sapiens (Human) [TaxID: 9606]
ORF1[Gene ID: 2943313 ]
♦Genome polyprotein [Cleaved into: Protein p11
♦ Protein p28
♦ NTPase (EC 3.6.1.15) (p35)
♦ Protein p32
♦ Viral genome-linked protein (VPg) (p14)
♦ Protease-polymerase p70 (Pro-Pol) (EC 2.7.7.48) (EC 3.4.22.66)
♦ Capsid protein (CP) (VP1) (p60)]
♦ Protein p28
♦ NTPase (EC 3.6.1.15) (p35)
♦ Protein p32
♦ Viral genome-linked protein (VPg) (p14)
♦ Protease-polymerase p70 (Pro-Pol) (EC 2.7.7.48) (EC 3.4.22.66)
♦ Capsid protein (CP) (VP1) (p60)]
Sapporo Virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)
Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Caliciviridae> Sapovirus> Sapporo Virus> Sapovirus GII> Sapporo Virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)
Not Available
Various pathway(s) in which protein is involved
Not Available
MASKPFYPIEFNPSVELQVLRSAHLRVGGREQMFETINDLNDHVRGVVAKLWCKHLHRSLAAAPTFTEEGLLDSFLSKPPVDINPDTTFRELFGINPHEQ
FPLSIHDLAKLQGELVDAARNPGHVLRRHYSTDSLTALINKITKFVPVHATLQEMQARRAFERERAELFRELPHADLDVSRQQKSYFYAMWRQVVKKSKE
FFIPLVKCTSWRKKFTEPAEIVRQVLVHFCEGMRSQFSTNANYINLSLIAKLRPTVLTMILQQHKNTYRGWLATVTALVEVYSNLFQDMRDTAVSAVSAI
TLVFETIKDFVVNVIDLVKSTFQSQGPTSCGWAAIIAGALLILMKLSGCSNTTSYWHRLLKVCGGVTTIAAAARAVVWVRDIIAEADGKARLKKYMARTA
ALLELAASRDVTGTDELKRLLDCFTQLIEEGTELIQEFGTSPLAGLTRSYVSELESTANSIRSTILLDTPRKTPVAIILTGPPGIGKTRLAQHLAAGFGK
VSNFSVTLDHHDSYTGNEVAIWDEFDVDTQGKFVETMIGVVNTAPYPLNCDRVENKGKVFTSDYIICTSNYPTSVLPDNPRAGAFYRRVTTIDVSSPTIE
DWKKKNPGKKPPPDLYKNDFTHLRLSVRPFLGYNPEGDTLDGVRVKPVLTSVDGLSRLMETKFKEQGNEHRNLWITCPRDLVAPAASGLKAYMAANRALA
QVFQEPSSQDIGETCTSRVYVSCNNPPPTYSGRVVKITAINPWDASLANSMLSMFETTSHIPASIQREIMYRVWDPLVHLQTREPNTQMLPYINRVVPVS
SAFDFIRGLRHHLGLCSVKGMWRAYQGWNSSSSILEFLSKHMADVAFPHNPECTVFRAPDGDVIFYTFGSYACFVSPARVPFVGEPPKNVHSNITRNMTW
AETLRLLAETITESLVHFGPFLLMMHNVSYLATRSGREEEAKGKTKHGRGAKHARRGGVSLSDDEYDEWRDLVRDWRQDMTVGEFVELRERYALGMDSED
VQRYRAWLELRAMRMGAGAYQHATIIGRGGVQDTIIRTQPMRAPRAPRNQGYDEEAPTPIVTFTSGGDHIGYGCHMGNGVVVTVTHVASASDQVEGQDFA
IRKTEGETTWVNTNLGHLPHYQIGDGAPVYYSARLHPVTTLAEGTYETPNITVQGYHLRIINGYPTKRGDCGTPYFDSCRRLVGLHAATSTNGETKLAQR
VTKTSKVENAFAWKGLPVVRGPDCGGMPTGTRYHRSPAWPNPVEGETHAPAPFGSGDERYKFSQVEMLVNGLKPYSEPTPGIPPALLQRAATHTRTYLET
IIGTHRSPNLSFSEACSLLEKSTSCGPFVAGQKGDYWDEDKQCYTGVLAEHLAKAWDAANRGVAPQNAYKLALKDELRPIEKNAQGKRRLLWGCDAGATL
VATAAFKGVATRLQAVAPMTPVSVGINMDSYQVEVLNESLKGGVLYCLDYSKWDSTQHPAVTAASLGILERLSEATPITTSAVELLSSPARGHLNDIVFI
TKSGLPSGMPFTSVINSLNHMTYFAAAVLKAYEQHGAPYTGNVFQVETVHTYGDDCLYSVCPATASIFQTVLANLTSFGLKPTAADKSETIAPTHTPVFL
KRTLTCTPRGVRGLLDITSIKRQFLWIKANRTVDINSPPAYDRDARGIQLENALAYASQHGHAVFEEVAELARHTAKAEGLVLTNVNYDQALATYESWFI
GGTGLVQGSPSEETTKLVFEMEGLGQPQPQGGEKTSPQPVTPQDTIGPTAALLLPTQIETPNASAQRLELAMATGAVTSNVPNCIRECFASVTTIPWTTR
QAANTFLGAIHLGPRINPYTAHLSAMFAGWGGGFQVRVTISGSGLFAGRAVTAILPPGVNPASVQNPGVFPHAFIDARTTEPILINLPDIRPVDFHRVDG
DDATASVGLWVAQPLINPFQTGPVSTCWLSFETRPGPDFDFCLLKAPEQQMDNGISPASLLPRRLGRSRGNRMGGRIVGLVVVAAAEQVNHHFDARSTTL
GWSTLPVEPIAGDISWYGDAGNKSIRGLVSAQGKGIIFPNIVNHWTDVALSSKTSNTTTIPTDTSTLGNLPGASGPLVTFADNGDVNESSAQNAILTAAN
QNFTSFSPTFDAAGIWVWMPWATDRPGASDSNIYISPTWVNGNPSHPIHEKCTNMIGTNFQFGGTGTNNIMLWQEQHFTSWPGAAEVYCSQLESTAEIFQ
NNIVNIPMNQMAVFNVETAGNSFQIAILPNGYCVTNAPVGTHQLLDYETSFKFVGLFPQSTSLQGPHGNSGRAVRFLE
FPLSIHDLAKLQGELVDAARNPGHVLRRHYSTDSLTALINKITKFVPVHATLQEMQARRAFERERAELFRELPHADLDVSRQQKSYFYAMWRQVVKKSKE
FFIPLVKCTSWRKKFTEPAEIVRQVLVHFCEGMRSQFSTNANYINLSLIAKLRPTVLTMILQQHKNTYRGWLATVTALVEVYSNLFQDMRDTAVSAVSAI
TLVFETIKDFVVNVIDLVKSTFQSQGPTSCGWAAIIAGALLILMKLSGCSNTTSYWHRLLKVCGGVTTIAAAARAVVWVRDIIAEADGKARLKKYMARTA
ALLELAASRDVTGTDELKRLLDCFTQLIEEGTELIQEFGTSPLAGLTRSYVSELESTANSIRSTILLDTPRKTPVAIILTGPPGIGKTRLAQHLAAGFGK
VSNFSVTLDHHDSYTGNEVAIWDEFDVDTQGKFVETMIGVVNTAPYPLNCDRVENKGKVFTSDYIICTSNYPTSVLPDNPRAGAFYRRVTTIDVSSPTIE
DWKKKNPGKKPPPDLYKNDFTHLRLSVRPFLGYNPEGDTLDGVRVKPVLTSVDGLSRLMETKFKEQGNEHRNLWITCPRDLVAPAASGLKAYMAANRALA
QVFQEPSSQDIGETCTSRVYVSCNNPPPTYSGRVVKITAINPWDASLANSMLSMFETTSHIPASIQREIMYRVWDPLVHLQTREPNTQMLPYINRVVPVS
SAFDFIRGLRHHLGLCSVKGMWRAYQGWNSSSSILEFLSKHMADVAFPHNPECTVFRAPDGDVIFYTFGSYACFVSPARVPFVGEPPKNVHSNITRNMTW
AETLRLLAETITESLVHFGPFLLMMHNVSYLATRSGREEEAKGKTKHGRGAKHARRGGVSLSDDEYDEWRDLVRDWRQDMTVGEFVELRERYALGMDSED
VQRYRAWLELRAMRMGAGAYQHATIIGRGGVQDTIIRTQPMRAPRAPRNQGYDEEAPTPIVTFTSGGDHIGYGCHMGNGVVVTVTHVASASDQVEGQDFA
IRKTEGETTWVNTNLGHLPHYQIGDGAPVYYSARLHPVTTLAEGTYETPNITVQGYHLRIINGYPTKRGDCGTPYFDSCRRLVGLHAATSTNGETKLAQR
VTKTSKVENAFAWKGLPVVRGPDCGGMPTGTRYHRSPAWPNPVEGETHAPAPFGSGDERYKFSQVEMLVNGLKPYSEPTPGIPPALLQRAATHTRTYLET
IIGTHRSPNLSFSEACSLLEKSTSCGPFVAGQKGDYWDEDKQCYTGVLAEHLAKAWDAANRGVAPQNAYKLALKDELRPIEKNAQGKRRLLWGCDAGATL
VATAAFKGVATRLQAVAPMTPVSVGINMDSYQVEVLNESLKGGVLYCLDYSKWDSTQHPAVTAASLGILERLSEATPITTSAVELLSSPARGHLNDIVFI
TKSGLPSGMPFTSVINSLNHMTYFAAAVLKAYEQHGAPYTGNVFQVETVHTYGDDCLYSVCPATASIFQTVLANLTSFGLKPTAADKSETIAPTHTPVFL
KRTLTCTPRGVRGLLDITSIKRQFLWIKANRTVDINSPPAYDRDARGIQLENALAYASQHGHAVFEEVAELARHTAKAEGLVLTNVNYDQALATYESWFI
GGTGLVQGSPSEETTKLVFEMEGLGQPQPQGGEKTSPQPVTPQDTIGPTAALLLPTQIETPNASAQRLELAMATGAVTSNVPNCIRECFASVTTIPWTTR
QAANTFLGAIHLGPRINPYTAHLSAMFAGWGGGFQVRVTISGSGLFAGRAVTAILPPGVNPASVQNPGVFPHAFIDARTTEPILINLPDIRPVDFHRVDG
DDATASVGLWVAQPLINPFQTGPVSTCWLSFETRPGPDFDFCLLKAPEQQMDNGISPASLLPRRLGRSRGNRMGGRIVGLVVVAAAEQVNHHFDARSTTL
GWSTLPVEPIAGDISWYGDAGNKSIRGLVSAQGKGIIFPNIVNHWTDVALSSKTSNTTTIPTDTSTLGNLPGASGPLVTFADNGDVNESSAQNAILTAAN
QNFTSFSPTFDAAGIWVWMPWATDRPGASDSNIYISPTWVNGNPSHPIHEKCTNMIGTNFQFGGTGTNNIMLWQEQHFTSWPGAAEVYCSQLESTAEIFQ
NNIVNIPMNQMAVFNVETAGNSFQIAILPNGYCVTNAPVGTHQLLDYETSFKFVGLFPQSTSLQGPHGNSGRAVRFLE
2278
VAR_SEQ 1 1720 Missing (in isoform Subgenomic capsid protein)
Not Available
05-07-2004
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity).
♦ Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).
♦ Protease-polymerase p70 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved (By similarity). It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
♦ Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
♦ Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).
♦ Protease-polymerase p70 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved (By similarity). It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
♦ Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
3.6.1.15 , 2.7.7.48 , 3.4.22.66
GO:0003723 ; GO:0003724 ; GO:0003968 ; GO:0004197 ; GO:0005524 ;
GO:0006260 ; GO:0006351 ; GO:0018144 ; GO:0019028 ; GO:0030430 ;
GO:0039694
GO:0006260 ; GO:0006351 ; GO:0018144 ; GO:0019028 ; GO:0030430 ;
GO:0039694
Capsid protein: Virion. Host cytoplasm.
♦DOMAIN 454 609 SF3 helicase.
♦ DOMAIN 1071 1177 Peptidase C24.
♦ DOMAIN 1443 1568 RdRp catalytic.
♦ DOMAIN 1071 1177 Peptidase C24.
♦ DOMAIN 1443 1568 RdRp catalytic.
Not Available
Predicted/Modelled
Not Available
♦ACT_SITE 1086 1086 For protease activity.
♦ ACT_SITE 1107 1107 For protease activity.
♦ ACT_SITE 1171 1171 For protease activity.
♦ ACT_SITE 1107 1107 For protease activity.
♦ ACT_SITE 1171 1171 For protease activity.
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available