Reviewed
Homo Sapiens (Human) [TaxID: 9606]
L[Gene ID: 2799943 ]
♦RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ mRNA guanylyltransferase (EC 2.7.7.-)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ mRNA guanylyltransferase (EC 2.7.7.-)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)]
Human Metapneumovirus (strain CAN97-83) (HMPV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Pneumoviridae> Metapneumovirus> Human Metapneumovirus> Human Metapneumovirus (strain CAN97-83) (HMPV)
Not Available
Various pathway(s) in which protein is involved
Not Available
MDPLNESTVNVYLPDSYLKGVISFSETNAIGSCLLKRPYLKNDNTAKVAIENPVIEHVRLKNAVNSKMKISDYKVVEPVNMQHEIMKNVHSCELTLLKQF
LTRSKNISTLKLNMICDWLQLKSTSDDTSILSFIDVEFIPSWVSNWFSNWYNLNKLILEFRREEVIRTGSILCRSLGKLVFIVSSYGCIVKSNKSKRVSF
FTYNQLLTWKDVMLSRFNANFCIWVSNSLNENQEGLGLRSNLQGMLTNKLYETVDYMLSLCCNEGFSLVKEFEGFIMSEILRITEHAQFSTRFRNTLLNG
LTDQLTKLKNKNRLRVHSTVLENNDYPMYEVVLKLLGDTLRCIKLLINKNLENAAELYYIFRIFGHPMVDERDAMDAVKLNNEITKILRLESLTELRGAF
ILRIIKGFVDNNKRWPKIKNLKVLSKRWTMYFKAKNYPSQLELSEQDFLELAAIQFEQEFSVPEKTNLEMVLNDKAISPPKRLIWSVYPKNYLPETIKNR
YLEETFNASDSLKTRRVLEYYLKDNKFDQKELKSYVVRQEYLNDKEHIVSLTGKERELSVGRMFAMQPGKQRQIQILAEKLLADNIVPFFPETLTKYGDL
DLQRIMEIKSELSSIKTRRNDSYNNYIARASIVTDLSKFNQAFRYETTAICADVADELHGTQSLFCWLHLIVPMTTMICAYRHAPPETKGEYDIDKIEEQ
SGLYRYHMGGIEGWCQKLWTMEAISLLDVVSVKTRCQMTSLLNGDNQSIDVSKPVKLSEGLDEVKADYRLAVKMLKEIRDAYRNIGHKLKEGETYISRDL
QFISKVIQSEGVMHPTPIKKVLRVGPWINTILDDIKTSAESIGSLCQELEFRGESIIVSLILRNFWLYNLYMHESKQHPLAGKQLFKQLNKTLTSVQRFF
EIKRENEVVDLWMNIPMQFGGGDPVVFYRSFYRRTPDFLTEAISHVDILLKISANIKNETKVSFFKALLSIEKNERATLTTLMRDPQAVGSERQAKVTSD
INRTAVTSILSLSPNQLFSDSAIHYSRNEEEVGIIAENITPVYPHGLRVLYESLPFHKAEKVVNMISGTKSITNLLQRTSAINGEDIDRAVSMMLENLGL
LSRILSVVVDSIEIPIKSNGRLICCQISRTLRETSWNNMEIVGVTSPSITTCMDVIYATSSHLKGIIIEKFSTDRTTRGQRGPKSPWVGSSTQEKKLVPV
YNRQILSKQQREQLEAIGKMRWVYKGTPGLRRLLNKICLGSLGISYKCVKPLLPRFMSVNFLHRLSVSSRPMEFPASVPAYRTTNYHFDTSPINQALSER
FGNEDINLVFQNAISCGISIMSVVEQLTGRSPKQLVLIPQLEEIDIMPPPVFQGKFNYKLVDKITSDQHIFSPDKIDMLTLGKMLMPTIKGQKTDQFLNK
RENYFHGNNLIESLSAALACHWCGILTEQCIENNIFKKDWGDGFISDHAFMDFKIFLCVFKTKLLCSWGSQGKNIKDEDIVDESIDKLLRIDNTFWRMFS
KVMFEPKVKKRIMLYDVKFLSLVGYIGFKNWFIEQLRSAELHEIPWIVNAEGDLVEIKSIKIYLQLIEQSLFLRITVLNYTDMAHALTRLIRKKLMCDNA
LLTPISSPMVNLTQVIDPTTQLDYFPKITFERLKNYDTSSNYAKGKLTRNYMILLPWQHVNRYNFVFSSTGCKVSLKTCIGKLMKDLNPKVLYFIGEGAG
NWMARTACEYPDIKFVYRSLKDDLDHHYPLEYQRVIGELSRIIDSGEGLSMETTDATQKTHWDLIHRVSKDALLITLCDAEFKDRDDFFKMVILWRKHVL
SCRICTTYGTDLYLFAKYHAKDCNVKLPFFVRSVATFIMQGSKLSGSECYILLTLGHHNSLPCHGEIQNSKMKIAVCNDFYAAKKLDNKSIEANCKSLLS
GLRIPINKKELDRQRRLLTLQSNHSSVATVGGSKIIESKWLTNKASTIIDWLEHILNSPKGELNYDFFEALENTYPNMIKLIDNLGNAEIKKLIKVTGYM
LVSKK
LTRSKNISTLKLNMICDWLQLKSTSDDTSILSFIDVEFIPSWVSNWFSNWYNLNKLILEFRREEVIRTGSILCRSLGKLVFIVSSYGCIVKSNKSKRVSF
FTYNQLLTWKDVMLSRFNANFCIWVSNSLNENQEGLGLRSNLQGMLTNKLYETVDYMLSLCCNEGFSLVKEFEGFIMSEILRITEHAQFSTRFRNTLLNG
LTDQLTKLKNKNRLRVHSTVLENNDYPMYEVVLKLLGDTLRCIKLLINKNLENAAELYYIFRIFGHPMVDERDAMDAVKLNNEITKILRLESLTELRGAF
ILRIIKGFVDNNKRWPKIKNLKVLSKRWTMYFKAKNYPSQLELSEQDFLELAAIQFEQEFSVPEKTNLEMVLNDKAISPPKRLIWSVYPKNYLPETIKNR
YLEETFNASDSLKTRRVLEYYLKDNKFDQKELKSYVVRQEYLNDKEHIVSLTGKERELSVGRMFAMQPGKQRQIQILAEKLLADNIVPFFPETLTKYGDL
DLQRIMEIKSELSSIKTRRNDSYNNYIARASIVTDLSKFNQAFRYETTAICADVADELHGTQSLFCWLHLIVPMTTMICAYRHAPPETKGEYDIDKIEEQ
SGLYRYHMGGIEGWCQKLWTMEAISLLDVVSVKTRCQMTSLLNGDNQSIDVSKPVKLSEGLDEVKADYRLAVKMLKEIRDAYRNIGHKLKEGETYISRDL
QFISKVIQSEGVMHPTPIKKVLRVGPWINTILDDIKTSAESIGSLCQELEFRGESIIVSLILRNFWLYNLYMHESKQHPLAGKQLFKQLNKTLTSVQRFF
EIKRENEVVDLWMNIPMQFGGGDPVVFYRSFYRRTPDFLTEAISHVDILLKISANIKNETKVSFFKALLSIEKNERATLTTLMRDPQAVGSERQAKVTSD
INRTAVTSILSLSPNQLFSDSAIHYSRNEEEVGIIAENITPVYPHGLRVLYESLPFHKAEKVVNMISGTKSITNLLQRTSAINGEDIDRAVSMMLENLGL
LSRILSVVVDSIEIPIKSNGRLICCQISRTLRETSWNNMEIVGVTSPSITTCMDVIYATSSHLKGIIIEKFSTDRTTRGQRGPKSPWVGSSTQEKKLVPV
YNRQILSKQQREQLEAIGKMRWVYKGTPGLRRLLNKICLGSLGISYKCVKPLLPRFMSVNFLHRLSVSSRPMEFPASVPAYRTTNYHFDTSPINQALSER
FGNEDINLVFQNAISCGISIMSVVEQLTGRSPKQLVLIPQLEEIDIMPPPVFQGKFNYKLVDKITSDQHIFSPDKIDMLTLGKMLMPTIKGQKTDQFLNK
RENYFHGNNLIESLSAALACHWCGILTEQCIENNIFKKDWGDGFISDHAFMDFKIFLCVFKTKLLCSWGSQGKNIKDEDIVDESIDKLLRIDNTFWRMFS
KVMFEPKVKKRIMLYDVKFLSLVGYIGFKNWFIEQLRSAELHEIPWIVNAEGDLVEIKSIKIYLQLIEQSLFLRITVLNYTDMAHALTRLIRKKLMCDNA
LLTPISSPMVNLTQVIDPTTQLDYFPKITFERLKNYDTSSNYAKGKLTRNYMILLPWQHVNRYNFVFSSTGCKVSLKTCIGKLMKDLNPKVLYFIGEGAG
NWMARTACEYPDIKFVYRSLKDDLDHHYPLEYQRVIGELSRIIDSGEGLSMETTDATQKTHWDLIHRVSKDALLITLCDAEFKDRDDFFKMVILWRKHVL
SCRICTTYGTDLYLFAKYHAKDCNVKLPFFVRSVATFIMQGSKLSGSECYILLTLGHHNSLPCHGEIQNSKMKIAVCNDFYAAKKLDNKSIEANCKSLLS
GLRIPINKKELDRQRRLLTLQSNHSSVATVGGSKIIESKWLTNKASTIIDWLEHILNSPKGELNYDFFEALENTYPNMIKLIDNLGNAEIKKLIKVTGYM
LVSKK
2005
Not Available
Not Available
05-07-2004
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
2.7.7.48 , 2.1.1.56 , 2.7.7.- , 2.7.7.88
Virion . Host cytoplasm .
♦DOMAIN 628 811 RdRp catalytic.
♦ DOMAIN 1662 1852 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1662 1852 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
X-ray crystallography (1)
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available