Reviewed
Chlorocebus Aethiops (Green Monkey) (Cercopithecus Aethiops) [TaxID: 9534]; Homo Sapiens (Human) [TaxID: 9606]; Rousettus Aegyptiacus (Egyptian Rousette) (Egyptian Fruit Bat) [TaxID: 9407]
L
♦RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
Lake Victoria Marburgvirus (strain Ozolin-75) (MARV) (Marburg Virus (strain South Africa/Ozolin/1975))
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Filoviridae> Marburgvirus> Marburg Marburgvirus> Lake Victoria Marburgvirus (strain Ozolin-75) (MARV) (Marburg Virus (strain South Africa/Ozolin/1975))
Various pathway(s) in which protein is involved
Not Available
Not Available
MQHPTQYPDARLSSPIVLDQCDLLARSLGLYSHYSHNPKLRNCRIPHHIYRLRNSTALKTFLQNCSILTVPFHSIWDHILTSIQYDAINHVDDFKYLLPS
ELVKYANWDNEFLKTYLNKILRLDHVFPASARSQCEDFSPKENPYYWGMLLLVHLSQLARRIKGQRGSLRSNWKFIGTDLELFGIADFIIFKVPVKTIIR
NAVSLQASKPGLRVWYRDQNLTPYLCDDEFIVSVASYECFIMIKDVFIERYNTWEICARAWLEDSDGADYPPLDVLGELYNYGDQIIAMYLEDGFKLIKH
LEPLCVSCIQTHGIFTPRKYWFQSQMIKSYYDELCDLNLKLRISDNKAECAQNFIKTIIQARLTPQQYCELFSLQKHWGHPVLYNDVALDKVKKHAQATK
ILKPKVMFETFCVFKFIVAKNHYHSQGSWYKTTHDLHLTPYLRQHIVSNSFPSQAEIYQHLWEWYFVEHEPLFSTKIISDLSIFIKDRATAVNQECWDSV
FDRSVLGYNPPVRFQSKRVPEQFLGQADFSLNQILDFAEKLEYLAPSYRNFSFSLKEKELNIGRTFGKLPYRVRNVQTLAEALLADGLAKAFPSNMMVVT
EREQKEALLHQASWHHNSASIGENAIVRGASFVTDLEKYNLAFRYEFTRHFINYCNRCYGVKNLFDWMHFLIPLCYMHVSDFYSPPHCVTEDNRNNPPDC
ANAYHYHLGGIEGLQQKLWTCISCAQITLVELKTKLKLKSSVMGDNQCITTLSLFPIDAPNDYQENEAELNAARVAVELAITTGYSGIFLKPEETFVHSG
FIYFGKKQYLNGVQLPQSLKTMARCGPLSDSIFDDLQGSLASIGTSFERGTSETRHIFPSRWIASFHSMLAINLLNQNHLGFPLGFNIDISCFKKPLTFS
EKLIALITPQVLGGLSFLNPEKLFYRNISDPLTSGLFQLKNALEFLGKGELFYILIAKKPGLADASDFVMNPLGLNVPGSREIITFLRQTVRENITITSQ
NRIINSLFHIGSDLEDQKVCEWLLSSNPVMSRFAADIFSRTPSGKRLQVLGYLEGTRTLLASRTISLTTEGTMLMKLRELTRNRWKSWFSYIDALDDDLS
ESLEKFTCTVDVANFLRAYSWSDVLKGKRLIGATLPCLLEQFKVKWINLSEDLREQFNLSSESELTINLLPYDCKELRLGGSHDTELNYVSCALDRKVVQ
KHPSVKRLAWTIGNRAPYIGSRTEDKIGYPPLRVNCPSAALKEAIEMVSRLLWVTQGTADREKLLIPLLNSRVNLDYQTVLNFLPTHYSGNIVHRYNDQY
GQHSFMANRMSNTSTRAIISTNTLGKYAGGGQAAIDSNIIFQNTINLGVAVLDIALSLAKLSSASNVTFRLMLNKCCTRHVPSEYLFFDKPLDVDLNKYM
DNELVYDNDPLCSGIKGRLGRVSRSTLSLSLNVSDIGSYDFPTIAAWTLGETIVGSIFSDESSQSTDPISSGCTKTFVTHFLVYPVESIFYAFGANLIVE
SLSLSRIKSIKNLSDLTFLISSTIRNLSHRSLRILQSTFRHELVLTRLAHHIPLISLMLGGSAGEKSSSDAVRLFLTASYQNFIHNFSCLMKKGQSSLPV
WLYFPSEGQQLKPILKILQRLSDLLSPDKVQRCKTLADTCCSIDSFWVYPSKSTRTNHYYASLNYWRDKANKVKNTPFSHLINCSFLELSSHTSSVSSNQ
QVTNSKYIVHPEDIPEINTRTKLIEYGSTALQRMDIKMPPSEQNLVENCRPSKDIRFKDNQKITKHDQRYEKKESSQQQMSPEDNMQTLAYMHNSSPSQT
FIKSIDVHEDFDASRVILNSKINNFNLTDCTINTNLLTTPTGTEFLDTSPLQSSRYSSTPRERSLLSREQASYLYVDCSNIPSISLDPGFRNMSDQNQIQ
MLINAYKRDLHACFDSNQFCRFTGVVSSMHYKLYDLLPPGELRKAICLAEGEGSGARLLLKWKETDHLFFNTLATDSQQEAEILSGRVIPRMLYNIDRLS
ALLESRRLILNNLTIQITDITNPLWLDSVIQYLPEDSDILTMDAETTKDETREQLYKTIVNIWTRTSPNIPKISIIKVFLLDYEGTLFLMKNAIQYYGQV
QLKKPYSSNAKNSEWYLCCSKRRIQRLQIDFPDQVGIFLICKAMSRQRQAIPYWLKHIEKNYPASLHEFFLTLGFPSLESSFCHRYTIPFSEGKALFHKV
QSYVRQGKQHLHSLMLDYENNSPLLDLRNHFICSLRGKITKYYNDILKLNLVIKAVEKGKNWSQLVETLPNMHSVCIVHVDHECFGCEKRLLLKLDFIRN
TKIAEQKLLNRVIGYILFFPFGLSKSRSLRA
ELVKYANWDNEFLKTYLNKILRLDHVFPASARSQCEDFSPKENPYYWGMLLLVHLSQLARRIKGQRGSLRSNWKFIGTDLELFGIADFIIFKVPVKTIIR
NAVSLQASKPGLRVWYRDQNLTPYLCDDEFIVSVASYECFIMIKDVFIERYNTWEICARAWLEDSDGADYPPLDVLGELYNYGDQIIAMYLEDGFKLIKH
LEPLCVSCIQTHGIFTPRKYWFQSQMIKSYYDELCDLNLKLRISDNKAECAQNFIKTIIQARLTPQQYCELFSLQKHWGHPVLYNDVALDKVKKHAQATK
ILKPKVMFETFCVFKFIVAKNHYHSQGSWYKTTHDLHLTPYLRQHIVSNSFPSQAEIYQHLWEWYFVEHEPLFSTKIISDLSIFIKDRATAVNQECWDSV
FDRSVLGYNPPVRFQSKRVPEQFLGQADFSLNQILDFAEKLEYLAPSYRNFSFSLKEKELNIGRTFGKLPYRVRNVQTLAEALLADGLAKAFPSNMMVVT
EREQKEALLHQASWHHNSASIGENAIVRGASFVTDLEKYNLAFRYEFTRHFINYCNRCYGVKNLFDWMHFLIPLCYMHVSDFYSPPHCVTEDNRNNPPDC
ANAYHYHLGGIEGLQQKLWTCISCAQITLVELKTKLKLKSSVMGDNQCITTLSLFPIDAPNDYQENEAELNAARVAVELAITTGYSGIFLKPEETFVHSG
FIYFGKKQYLNGVQLPQSLKTMARCGPLSDSIFDDLQGSLASIGTSFERGTSETRHIFPSRWIASFHSMLAINLLNQNHLGFPLGFNIDISCFKKPLTFS
EKLIALITPQVLGGLSFLNPEKLFYRNISDPLTSGLFQLKNALEFLGKGELFYILIAKKPGLADASDFVMNPLGLNVPGSREIITFLRQTVRENITITSQ
NRIINSLFHIGSDLEDQKVCEWLLSSNPVMSRFAADIFSRTPSGKRLQVLGYLEGTRTLLASRTISLTTEGTMLMKLRELTRNRWKSWFSYIDALDDDLS
ESLEKFTCTVDVANFLRAYSWSDVLKGKRLIGATLPCLLEQFKVKWINLSEDLREQFNLSSESELTINLLPYDCKELRLGGSHDTELNYVSCALDRKVVQ
KHPSVKRLAWTIGNRAPYIGSRTEDKIGYPPLRVNCPSAALKEAIEMVSRLLWVTQGTADREKLLIPLLNSRVNLDYQTVLNFLPTHYSGNIVHRYNDQY
GQHSFMANRMSNTSTRAIISTNTLGKYAGGGQAAIDSNIIFQNTINLGVAVLDIALSLAKLSSASNVTFRLMLNKCCTRHVPSEYLFFDKPLDVDLNKYM
DNELVYDNDPLCSGIKGRLGRVSRSTLSLSLNVSDIGSYDFPTIAAWTLGETIVGSIFSDESSQSTDPISSGCTKTFVTHFLVYPVESIFYAFGANLIVE
SLSLSRIKSIKNLSDLTFLISSTIRNLSHRSLRILQSTFRHELVLTRLAHHIPLISLMLGGSAGEKSSSDAVRLFLTASYQNFIHNFSCLMKKGQSSLPV
WLYFPSEGQQLKPILKILQRLSDLLSPDKVQRCKTLADTCCSIDSFWVYPSKSTRTNHYYASLNYWRDKANKVKNTPFSHLINCSFLELSSHTSSVSSNQ
QVTNSKYIVHPEDIPEINTRTKLIEYGSTALQRMDIKMPPSEQNLVENCRPSKDIRFKDNQKITKHDQRYEKKESSQQQMSPEDNMQTLAYMHNSSPSQT
FIKSIDVHEDFDASRVILNSKINNFNLTDCTINTNLLTTPTGTEFLDTSPLQSSRYSSTPRERSLLSREQASYLYVDCSNIPSISLDPGFRNMSDQNQIQ
MLINAYKRDLHACFDSNQFCRFTGVVSSMHYKLYDLLPPGELRKAICLAEGEGSGARLLLKWKETDHLFFNTLATDSQQEAEILSGRVIPRMLYNIDRLS
ALLESRRLILNNLTIQITDITNPLWLDSVIQYLPEDSDILTMDAETTKDETREQLYKTIVNIWTRTSPNIPKISIIKVFLLDYEGTLFLMKNAIQYYGQV
QLKKPYSSNAKNSEWYLCCSKRRIQRLQIDFPDQVGIFLICKAMSRQRQAIPYWLKHIEKNYPASLHEFFLTLGFPSLESSFCHRYTIPFSEGKALFHKV
QSYVRQGKQHLHSLMLDYENNSPLLDLRNHFICSLRGKITKYYNDILKLNLVIKAVEKGKNWSQLVETLPNMHSVCIVHVDHECFGCEKRLLLKLDFIRN
TKIAEQKLLNRVIGYILFFPFGLSKSRSLRA
2331
Not Available
Not Available
05-07-2004
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
2.7.7.48 , 2.1.1.56 , 2.7.7.88 , 2.1.1.296
Host cytoplasm. Virion .
♦DOMAIN 628 812 RdRp catalytic.
♦ DOMAIN 1921 2118 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1921 2118 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available