Results | viHumans

UniProt ID

Q6SWC9

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

RL13[Gene ID: 3077492 ]

Protein Name

Membrane protein RL13

Organism Name

Human Cytomegalovirus (strain Merlin) (HHV-5) (Human Herpesvirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Cytomegalovirus> Human Cytomegalovirus (HHV-5) (Human Herpesvirus 5)> Human Cytomegalovirus (strain Merlin) (HHV-5) (Human Herpesvirus 5)

RefSeq

Not Available

PubMed ID

15105547 ; 20679731

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3077492

Reactome

Not Available

Sequence

							MHWHLAITWTVIILTFSECYNQTCPCPCICVNSTTVSISTSETTSKNITPTTTTNSKKTTSSIATTTPSLVTTGKVVSTAASSTIISQTNRSHTSNAITT
PKTRFEYNITGYVGQEVTLNFTGSWNYIQWFRYGSPGWLYSSEPICTVTSNYHHTFPRGALCFDCDMTKLLIYDLTLNDSGKYVVKRTRHDNQYEEACYS
LTVIFANTTSIVTNRTCDRKRTENTDTTNHEIGKHIIETIKKANIPLGIHAVWAGIVVSVALIALYMGNRRRPRKPRYTRLPKYDPDESWTKT
						

Length

293

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

05-07-2004

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

May play a role in modifying tropism or in modulating cell signaling during virus entry. Since RL13 expression severely impairs HCMV replication in epithelial cell cultures, it may act as a regulator promoting persistence by suppressing the switch to fully lytic infection.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0055036

Subcellular Location

♦ Virion membrane
♦ Single-pass type I membrane protein .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available