Results | viHumans

UniProt ID

Q6Q1R8

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

N 6[Gene ID: 2943504 ]

Protein Name

Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

Organism Name

Human Coronavirus NL63 (HCoV-NL63)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Nidovirales> Coronaviridae> Coronavirinae> Alphacoronavirus> Human Coronavirus NL63 (HCoV-NL63)

RefSeq

NC_005831.2 ; AY567487.2

PubMed ID

15034574 ; 25700263

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:2943504

Reactome

Not Available

Sequence

							MASVNWADDRAARKKFPPPSFYMPLLVSSDKAPYRVIPRNLVPIGKGNKDEQIGYWNVQERWRMRRGQRVDLPPKVHFYYLGTGPHKDLKFRQRSDGVVW
VAKEGAKTVNTSLGNRKRNQKPLEPKFSIALPPELSVVEFEDRSNNSSRASSRSSTRNNSRDSSRSTSRQQSRTRSDSNQSSSDLVAAVTLALKNLGFDN
QSKSPSSSGTSTPKKPNKPLSQPRADKPSQLKKPRWKRVPTREENVIQCFGPRDFNHNMGDSDLVQNGVDAKGFPQLAELIPNQAALFFDSEVSTDEVGD
NVQITYTYKMLVAKDNKNLPKFIEQISAFTKPSSIKEMQSQSSHVAQNTVLNASIPESKPLADDDSAIIEIVNEVLH
						

Length

377

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

05-07-2004

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0003723 ; GO:0019013 ; GO:0030430 ; GO:0044172 ;
GO:0044177

Subcellular Location

Virion . Host endoplasmic reticulum-Golgi intermediate compartment . Host Golgi apparatus . Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (2)

Experimetally known structure

5EPW 5N4K

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available