Reviewed
Bandicota Bengalensis (lesser Bandicoot Rat) [TaxID: 69079]; Callithrix [TaxID: 9481]; Cercopithecus Hamlyni (Owl-faced Monkey) (Hamlyn's Monkey) [TaxID: 9536]; Chlorocebus Aethiops (Green Monkey) (Cercopithecus Aethiops) [TaxID: 9534]; Homo Sapiens (Human) [TaxID: 9606]; Macaca (macaques) [TaxID: 9539]; Mus Musculus (Mouse) [TaxID: 10090]; Pan Troglodytes (Chimpanzee) [TaxID: 9598]; Saimiri (squirrel Monkeys) [TaxID: 9520]; Sus Scrofa (Pig) [TaxID: 9823]
ORF1
♦Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-)
♦ Putative papain-like cysteine protease (PLP) (EC 3.4.22.-)
♦ NTPase/helicase (EC 3.6.4.-)
♦ RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48)]
♦ Putative papain-like cysteine protease (PLP) (EC 3.4.22.-)
♦ NTPase/helicase (EC 3.6.4.-)
♦ RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48)]
Hepatitis E Virus Genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E Virus Genotype 3 (isolate Swine/United States/Meng))
Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Hepeviridae> Orthohepevirus> Orthohepevirus A> Hepatitis E Virus (HEV)> Hepatitis E Virus Type 3> Hepatitis E Virus Genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E Virus Genotype 3 (isolate Swine/United States/Meng))
Various pathway(s) in which protein is involved
Not Available
Not Available
MEAQQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSRVQTEILINLMQPRQLVFRPEVLWNHPIQRVIHNELEQYCRARAGRCLEVGAHPRSINDNP
NVLHRCFLRPVGRDVQRWYSAPTRGPAANCRRSALRGLPPVDRTYCFDGFSRCAFAAETGVALYSLHDLWPADVAEAMARHGMTRLYAALHLPPEVLLPP
GTYHTTSYLLIHDGDRAVVTYEGDTSAGYNHDVSILRAWIRTTKIVGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPS
LFPSACSTKSTFHAVPVHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGALVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEV
EHAQKFITRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRVLVFDESVPCRCRTFLKKVAGKFCCFMRWLGQECTCFLEPAEGLVGDYGHDNE
AYEGSEVDPAEPAHLDVSGTYAVHGRQLEALYRALNVPHDIAARASRLTATVELTASPDRLECRTVLGNKTFRTTVVDGAHLEANGPEQYVLSFDASRQS
MGAGSHSLTYELTPAGLQVRISSNGLDCTATFPPGGAPSAAPGEVAAFCSALYRYNRFTQRHSLTGGLWLHPEGLLGIFPPFSPGHIWESANPFCGEGTL
YTRTWSTSGFSSDFSPPEAAAPVLAAAPGLPHPTPPVSDIWVLPPPSEESQVDAASVPPAPEPAGLPSSIVLTLPPPLPPVRKPPTPPPSRTRRLLYTYP
DGAKVYAGSLFESDCNWLVNASNPGHRPGGGLCHAFYQRFPEAFYPTEFIMREGLAAYTLTPRPIIHAVAPDYRVEQNPKRLEAAYRETCSRRGTAAYPL
LGSGIYQVPVSLSFDAWERNHRPGDELYLTEPAAAWFEANKPAQPALTITEDTARTANLALEIDAATDVGRACAGCTISPGIVHYQFTAGVPGSGKSRSI
QQGDVDVVVVPTRELRNSWRRRGFAAFTPHTAARVTIGRRVVIDEAPSLPPHLLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELAPTSWWHVT
HRCPADVCELIRGAYPKIQTTSRVLRSLFWNEPAIGQKLVFTQAAKAANPGAITVHEAQGATFTETTIIATADARGLIQSSRAHAIVALTRHTEKCVILD
APGLLREVGISDVIVNNFFLAGGEVGHHRPSVIPRGNPDQNLGTLQAFPPSCQISAYHQLAEELGHRPAPVAAVLPPCPELEQGLLYMPQELTVSDSVLV
FELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTKLYEAAHSDVRESLARFIPTIGPVQATTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDC
NKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKEILALLPPNIFYGDAYEESVFAAAVSGAGSCMVFENDFSEFDSTQNNFSLGLECVVMEECGM
PQWLIRLYHLVRSAWILQAPKESLKGFWKKHSGEPGTLLWNTVWNMAIIAHCYEFRDFRVAAFKGDDSVVLCSDYRQSRNAAALIAGCGLKLKVDYRPIG
LYAGVVVAPGLGTLPDVVRFAGRLSEKNWGPGPERAEQLRLAVCDFLRGLTNVAQVCVDVVSRVYGVSPGLVHNLIGMLQTIADGKAHFTETIKPVLDLT
NSIIQRVE
NVLHRCFLRPVGRDVQRWYSAPTRGPAANCRRSALRGLPPVDRTYCFDGFSRCAFAAETGVALYSLHDLWPADVAEAMARHGMTRLYAALHLPPEVLLPP
GTYHTTSYLLIHDGDRAVVTYEGDTSAGYNHDVSILRAWIRTTKIVGDHPLVIERVRAIGCHFVLLLTAAPEPSPMPYVPYPRSTEVYVRSIFGPGGSPS
LFPSACSTKSTFHAVPVHIWDRLMLFGATLDDQAFCCSRLMTYLRGISYKVTVGALVANEGWNASEDALTAVITAAYLTICHQRYLRTQAISKGMRRLEV
EHAQKFITRLYSWLFEKSGRDYIPGRQLQFYAQCRRWLSAGFHLDPRVLVFDESVPCRCRTFLKKVAGKFCCFMRWLGQECTCFLEPAEGLVGDYGHDNE
AYEGSEVDPAEPAHLDVSGTYAVHGRQLEALYRALNVPHDIAARASRLTATVELTASPDRLECRTVLGNKTFRTTVVDGAHLEANGPEQYVLSFDASRQS
MGAGSHSLTYELTPAGLQVRISSNGLDCTATFPPGGAPSAAPGEVAAFCSALYRYNRFTQRHSLTGGLWLHPEGLLGIFPPFSPGHIWESANPFCGEGTL
YTRTWSTSGFSSDFSPPEAAAPVLAAAPGLPHPTPPVSDIWVLPPPSEESQVDAASVPPAPEPAGLPSSIVLTLPPPLPPVRKPPTPPPSRTRRLLYTYP
DGAKVYAGSLFESDCNWLVNASNPGHRPGGGLCHAFYQRFPEAFYPTEFIMREGLAAYTLTPRPIIHAVAPDYRVEQNPKRLEAAYRETCSRRGTAAYPL
LGSGIYQVPVSLSFDAWERNHRPGDELYLTEPAAAWFEANKPAQPALTITEDTARTANLALEIDAATDVGRACAGCTISPGIVHYQFTAGVPGSGKSRSI
QQGDVDVVVVPTRELRNSWRRRGFAAFTPHTAARVTIGRRVVIDEAPSLPPHLLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELAPTSWWHVT
HRCPADVCELIRGAYPKIQTTSRVLRSLFWNEPAIGQKLVFTQAAKAANPGAITVHEAQGATFTETTIIATADARGLIQSSRAHAIVALTRHTEKCVILD
APGLLREVGISDVIVNNFFLAGGEVGHHRPSVIPRGNPDQNLGTLQAFPPSCQISAYHQLAEELGHRPAPVAAVLPPCPELEQGLLYMPQELTVSDSVLV
FELTDIVHCRMAAPSQRKAVLSTLVGRYGRRTKLYEAAHSDVRESLARFIPTIGPVQATTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRITFFQKDC
NKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKEILALLPPNIFYGDAYEESVFAAAVSGAGSCMVFENDFSEFDSTQNNFSLGLECVVMEECGM
PQWLIRLYHLVRSAWILQAPKESLKGFWKKHSGEPGTLLWNTVWNMAIIAHCYEFRDFRVAAFKGDDSVVLCSDYRQSRNAAALIAGCGLKLKVDYRPIG
LYAGVVVAPGLGTLPDVVRFAGRLSEKNWGPGPERAEQLRLAVCDFLRGLTNVAQVCVDVVSRVYGVSPGLVHNLIGMLQTIADGKAHFTETIKPVLDLT
NSIIQRVE
1708
Not Available
Not Available
05-07-2004
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦Methyltransferase displays a cytoplasmic capping enzyme activity. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. The enzymatic reaction involves a covalent link between 7-methyl-GMP and the methyltransferase, whereas eukaryotic capping enzymes form a covalent complex only with GMP. Methyltransferase catalyzes transfer of a methyl group from S-adenosylmethionine to GTP and GDP to yield m(7)GTP or m(7)GDP. GMP, GpppG, and GpppA were poor substrates for the methyltransferase. This enzyme also displays guanylyltransferase activity to form a covalent complex, methyltransferase-m(7)GMP, from which 7-methyl-GMP is transferred to the mRNA to create the cap structure. Cap analogs such as m(7)GTP, m(7)GDP, et(2)m(7)GMP, and m(2)et(7)GMP inhibit the methyltransferase reaction (By similarity).
♦ RNA-directed RNA polymerase plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA, probably to initiate replication (By similarity).
♦ Helicase region exhibits NTPase and RNA unwinding activities. Hydrolyzes all rNTPs efficiently and unwinds only RNA duplexes with 5' overhangs showing 5'-to-3' polarity (By similarity).
♦ RNA-directed RNA polymerase plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA, probably to initiate replication (By similarity).
♦ Helicase region exhibits NTPase and RNA unwinding activities. Hydrolyzes all rNTPs efficiently and unwinds only RNA duplexes with 5' overhangs showing 5'-to-3' polarity (By similarity).
2.1.1.- , 2.7.7.- , 3.4.22.- , 3.6.4.- , 2.7.7.48
GO:0003723 ; GO:0003968 ; GO:0004386 ; GO:0005524 ; GO:0006351 ;
GO:0006396 ; GO:0008174 ; GO:0008234 ; GO:0019082 ; GO:0039694
GO:0006396 ; GO:0008174 ; GO:0008234 ; GO:0019082 ; GO:0039694
Not Available
♦DOMAIN 56 240 Alphavirus-like MT.
♦ DOMAIN 790 936 Macro.
♦ DOMAIN 949 1097 (+)RNA virus helicase ATP-binding.
♦ DOMAIN 1098 1231 (+)RNA virus helicase C-terminal.
♦ DOMAIN 1469 1580 RdRp catalytic.
♦ DOMAIN 790 936 Macro.
♦ DOMAIN 949 1097 (+)RNA virus helicase ATP-binding.
♦ DOMAIN 1098 1231 (+)RNA virus helicase C-terminal.
♦ DOMAIN 1469 1580 RdRp catalytic.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available