Reviewed
Homo Sapiens (Human) [TaxID: 9606]
ORF1
♦Genome polyprotein [Cleaved into: Protein p28
♦ NTPase (EC 3.6.1.15) (p35)
♦ Protein p32
♦ Viral genome-linked protein (VPg) (p14)
♦ Protease-polymerase p70 (Pro-Pol) (EC 2.7.7.48) (EC 3.4.22.66)
♦ Capsid protein (CP) (VP1) (p60)] (Fragment)
♦ NTPase (EC 3.6.1.15) (p35)
♦ Protein p32
♦ Viral genome-linked protein (VPg) (p14)
♦ Protease-polymerase p70 (Pro-Pol) (EC 2.7.7.48) (EC 3.4.22.66)
♦ Capsid protein (CP) (VP1) (p60)] (Fragment)
Sapporo Virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)
Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Caliciviridae> Sapovirus> Sapporo Virus> Sapovirus GI> Sapporo Virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)
Not Available
Various pathway(s) in which protein is involved
Not Available
Not Available
MFGTKAPDSVQEGTLFRELFGVDQTEQFPLSLADLARLQGELVDATRTPGHALRQKYTMTTIQDLINKITKVVPVQATLNEMHARRQFERERADLFHELP
LVDEDAVAQPKTYFYTMWRQVVKKGKAYFCPLVKTSAWRTKISAITEPIKDFLIAFWQAVQQEMGVNPQYLQLAWLQKLKPTTLTIILQQHKHTVSGWLA
TMTALVEVYSNLFDDLRKSSVTIVSSIGAFFDICKDFVSQVVELVKTTFTAQGPTDLGWAAVLAGAAMILLKMSGCPGVIGMWTKVLKICGGITTITAAA
RGVRWLKDLYEEAEGRRLPKMYMARGAALIELAASREVTGVDELKGLLDCFTILIEEGTELIHKFGTSPLAGLVRTYVSELETQANNIRSTIKLDTPRRV
PVVIILTGAPGIGKTRLAQYIGQRFGKTSNFSVAVDHHDGYTGNTVCIWDEFDVDSKGAFVETMIGIANTAPFPLNCDRVENKGRVFTSDYVICTSNYPT
SVIPDNPRAAAFYRRVLTVDVSAPDLEEWKKRNPGKRPTPDLYQDDFSHLKLMLRPYLGYNPDGDTLEGPRVAPTQISIAGLITLMERRFKEQAGPLQNL
WLQVPKTLVEQSTNMVKAFMYANRAVCDVIPNPATRDITETALSKVFVCGTAPPPEFVGKHIVITGIEVGDASIANSLLSMFTTTTRLSAAAQREYMYRV
WSPLIHIQDRSMNTQNLPYINRVIPVTSHWDFLRGLRHHLGFTSIPGMWKAFQGWRTSQGIVDFVAHHMADVTFPSNPECTIFRTPDADVVFYTFGSYVC
FATPARVPYVGTPPTTIHSNTPRCMTWGETLALLCEVVAEFVLHFGPVILSAANIAYLMTRGSRTEEAKGKTKHGRGMRHGHRAGVSLSDDEYDEWRDLM
RDWRRDMSVNDFLMLRERSALGMDDEDVARYRAWLEIRAMRMAGGAYTHATIIGRGGVRDEIIRTSPRRAPTRPQQHYEEEGPTAIVEFTQGGDHIGYGV
HIGNGNVITVTHVASTSDEVNGSAFKITRTVGETTWVQGPFSQLPHMQIGSGSPVYFTTRLHPVFTISEGTFETPNITVNGFHVRIMNGYPTKKGDCGLP
YFNSNRQLVALHAGTDTQGETKVAQRVVKEVTTQDEFQWKGLPVVKSGLDVGGMPTGTRYHRSPAWPEEQPGETHAPAPFGSGDKRYTFSQTEMLVNGLK
PYTEPTAGVPPQLLSRAVTHVRSYIETIIGTHRSPVLTYHQACELLERTTSCGPFVQGLKGDYWDEEQQQYTGVLANHLEQAWDKANKGIAPRNAYKLAL
KDELRPIEKNKAGKRRLLWGCDAATTLIATAAFKAVATRLQVVTPMTPVAVGINMDSVQMQVMNDSLKGGVLYCLDYSKWDSTQNPAVTAASLAILERFA
EPHPIVSCAIEALSSPAEGYVNDIKFVTRGGLPSGMPFTSVVNSINHMIYVAAAILQAYESHNVPYTGNVFQVETIHTYGDDCMYSVCPATASIFHTVLA
NLTSYGLKPTAADKSDAIKPTNTPVFLKRTFTQTPHGIRALLDITSITRQFYWLKANRTSDPSSPPAFDRQARSAQLENALAYASQHGPVMFDTVRQIAI
KTAQGEGLVLVNTNYDQALATYNAWFIGGTVPDPVGHTEGTHKIVFEMEGNGSNPEPKQSNNPMVVDPPGTTGPTTSHVVVANPEQPNGAAQRLELAVAT
GAIQSNVPEAIRNCFAVFRTFAWNDRMPTGTFLGSISLHPNINPYTSHLSGMWAGWGGSFEVRLSISGSGVFAGRIIASVIPPGVDPSSIRDPGVLPHAF
VDARITEPVSFMIPDVRAVDYHRMDGAEPTCSLGFWVYQPLLNPFSTTAVSTCWVSVETKPGGDFDFCLLRPPGQQMENGVSPEGLLPRRLGYSRGNRVG
GLVVGMILVAEHKQVNRHFNSNSVTFGWSTAPVNPMAAEIVTNQAHSTSRHAWLSIGAQNKGPLFPGIPNHFPDSCASTVVGAMDTSLGGRPSTGVCGPA
ISFQNNGDVYENDTPSVMFATYDPLTSGTGVALTNSINPASLALVRISNNDFDTSGFANDKNVVVQMSWEMYTGTNQIRGQVTPMSGTNYTFTSTGANTL
VLWQERMLSYDGHQAILYSSQLERTAEYFQNDIVNIPENSMAVFNVETNSASFQIGIRPDGYMVTGGSIGVNVPLEPETRFQYVGILPLSAALSGPSGNM
GRARRVFQ
LVDEDAVAQPKTYFYTMWRQVVKKGKAYFCPLVKTSAWRTKISAITEPIKDFLIAFWQAVQQEMGVNPQYLQLAWLQKLKPTTLTIILQQHKHTVSGWLA
TMTALVEVYSNLFDDLRKSSVTIVSSIGAFFDICKDFVSQVVELVKTTFTAQGPTDLGWAAVLAGAAMILLKMSGCPGVIGMWTKVLKICGGITTITAAA
RGVRWLKDLYEEAEGRRLPKMYMARGAALIELAASREVTGVDELKGLLDCFTILIEEGTELIHKFGTSPLAGLVRTYVSELETQANNIRSTIKLDTPRRV
PVVIILTGAPGIGKTRLAQYIGQRFGKTSNFSVAVDHHDGYTGNTVCIWDEFDVDSKGAFVETMIGIANTAPFPLNCDRVENKGRVFTSDYVICTSNYPT
SVIPDNPRAAAFYRRVLTVDVSAPDLEEWKKRNPGKRPTPDLYQDDFSHLKLMLRPYLGYNPDGDTLEGPRVAPTQISIAGLITLMERRFKEQAGPLQNL
WLQVPKTLVEQSTNMVKAFMYANRAVCDVIPNPATRDITETALSKVFVCGTAPPPEFVGKHIVITGIEVGDASIANSLLSMFTTTTRLSAAAQREYMYRV
WSPLIHIQDRSMNTQNLPYINRVIPVTSHWDFLRGLRHHLGFTSIPGMWKAFQGWRTSQGIVDFVAHHMADVTFPSNPECTIFRTPDADVVFYTFGSYVC
FATPARVPYVGTPPTTIHSNTPRCMTWGETLALLCEVVAEFVLHFGPVILSAANIAYLMTRGSRTEEAKGKTKHGRGMRHGHRAGVSLSDDEYDEWRDLM
RDWRRDMSVNDFLMLRERSALGMDDEDVARYRAWLEIRAMRMAGGAYTHATIIGRGGVRDEIIRTSPRRAPTRPQQHYEEEGPTAIVEFTQGGDHIGYGV
HIGNGNVITVTHVASTSDEVNGSAFKITRTVGETTWVQGPFSQLPHMQIGSGSPVYFTTRLHPVFTISEGTFETPNITVNGFHVRIMNGYPTKKGDCGLP
YFNSNRQLVALHAGTDTQGETKVAQRVVKEVTTQDEFQWKGLPVVKSGLDVGGMPTGTRYHRSPAWPEEQPGETHAPAPFGSGDKRYTFSQTEMLVNGLK
PYTEPTAGVPPQLLSRAVTHVRSYIETIIGTHRSPVLTYHQACELLERTTSCGPFVQGLKGDYWDEEQQQYTGVLANHLEQAWDKANKGIAPRNAYKLAL
KDELRPIEKNKAGKRRLLWGCDAATTLIATAAFKAVATRLQVVTPMTPVAVGINMDSVQMQVMNDSLKGGVLYCLDYSKWDSTQNPAVTAASLAILERFA
EPHPIVSCAIEALSSPAEGYVNDIKFVTRGGLPSGMPFTSVVNSINHMIYVAAAILQAYESHNVPYTGNVFQVETIHTYGDDCMYSVCPATASIFHTVLA
NLTSYGLKPTAADKSDAIKPTNTPVFLKRTFTQTPHGIRALLDITSITRQFYWLKANRTSDPSSPPAFDRQARSAQLENALAYASQHGPVMFDTVRQIAI
KTAQGEGLVLVNTNYDQALATYNAWFIGGTVPDPVGHTEGTHKIVFEMEGNGSNPEPKQSNNPMVVDPPGTTGPTTSHVVVANPEQPNGAAQRLELAVAT
GAIQSNVPEAIRNCFAVFRTFAWNDRMPTGTFLGSISLHPNINPYTSHLSGMWAGWGGSFEVRLSISGSGVFAGRIIASVIPPGVDPSSIRDPGVLPHAF
VDARITEPVSFMIPDVRAVDYHRMDGAEPTCSLGFWVYQPLLNPFSTTAVSTCWVSVETKPGGDFDFCLLRPPGQQMENGVSPEGLLPRRLGYSRGNRVG
GLVVGMILVAEHKQVNRHFNSNSVTFGWSTAPVNPMAAEIVTNQAHSTSRHAWLSIGAQNKGPLFPGIPNHFPDSCASTVVGAMDTSLGGRPSTGVCGPA
ISFQNNGDVYENDTPSVMFATYDPLTSGTGVALTNSINPASLALVRISNNDFDTSGFANDKNVVVQMSWEMYTGTNQIRGQVTPMSGTNYTFTSTGANTL
VLWQERMLSYDGHQAILYSSQLERTAEYFQNDIVNIPENSMAVFNVETNSASFQIGIRPDGYMVTGGSIGVNVPLEPETRFQYVGILPLSAALSGPSGNM
GRARRVFQ
2208
VAR_SEQ 1 1647 Missing (in isoform Subgenomic capsid protein)
Not Available
01-11-1997
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity).
♦ Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).
♦ Protease-polymerase processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved.
♦ Protease-polymerase is an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
♦ Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
♦ Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).
♦ Protease-polymerase processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved.
♦ Protease-polymerase is an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
♦ Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
3.6.1.15 , 2.7.7.48 , 3.4.22.66
GO:0003723 ; GO:0003724 ; GO:0003968 ; GO:0004197 ; GO:0005524 ;
GO:0006260 ; GO:0006351 ; GO:0018144 ; GO:0019028 ; GO:0030430 ;
GO:0039694
GO:0006260 ; GO:0006351 ; GO:0018144 ; GO:0019028 ; GO:0030430 ;
GO:0039694
Capsid protein: Virion. Host cytoplasm.
♦DOMAIN 382 536 SF3 helicase.
♦ DOMAIN 997 1103 Peptidase C24.
♦ DOMAIN 1370 1495 RdRp catalytic.
♦ DOMAIN 997 1103 Peptidase C24.
♦ DOMAIN 1370 1495 RdRp catalytic.
Not Available
X-ray crystallography (4)
♦ACT_SITE 1012 1012 For protease activity.
♦ ACT_SITE 1033 1033 For protease activity.
♦ ACT_SITE 1097 1097 For protease activity.
♦ ACT_SITE 1033 1033 For protease activity.
♦ ACT_SITE 1097 1097 For protease activity.
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available