Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Mammalia [TaxID: 40674]
G
Glycoprotein
Rabies Virus (strain Silver-haired Bat-associated) (RABV) (SHBRV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Rhabdoviridae> Lyssavirus> Rabies Lyssavirus> Rabies Virus (strain Silver-haired Bat-associated) (RABV) (SHBRV)
Various pathway(s) in which protein is involved
Not Available
Not Available
MIPQALLFVPLLIPSLCLGKFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTSLSGFSYMELKVGYISAMKVNGFTCTGVVTEAETYTNFVGYVTTT
FKRKHFRPMPDACRAAHDWKIAGDPRYEDSLQNPYPDYHWLRTVKTTKESLVIISPSVADLDPYDKSLHSRVFPSGKCLGITVSSTYCPTNHDYTIWMPV
EARLGTSCDIFTNSRGKKASKGGRTCGFVDERGLYKSLKGACKLKLCGVPGLRLMNGTWVSIQTSDDIKWCPPDQLVNLHDFHSDEIEHLVVEELIKKRE
GCLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNNTLMEADAHYKSVRTWNEVIPSKGCLKVGGRCHPPVNGVFFNGIILGPDGNVLIPEMQSSLL
QQHMELLESSVIPLMHPLADPSTVFKDGDEAEDFVEVHLPDVHKQVSDVDLGLPSWGKYLLMSAGALATLILAIFLITCCRRANRTKSTQRGHRESGGKV
SVAPQNGKIISSWELYKSESETGM
FKRKHFRPMPDACRAAHDWKIAGDPRYEDSLQNPYPDYHWLRTVKTTKESLVIISPSVADLDPYDKSLHSRVFPSGKCLGITVSSTYCPTNHDYTIWMPV
EARLGTSCDIFTNSRGKKASKGGRTCGFVDERGLYKSLKGACKLKLCGVPGLRLMNGTWVSIQTSDDIKWCPPDQLVNLHDFHSDEIEHLVVEELIKKRE
GCLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNNTLMEADAHYKSVRTWNEVIPSKGCLKVGGRCHPPVNGVFFNGIILGPDGNVLIPEMQSSLL
QQHMELLESSVIPLMHPLADPSTVFKDGDEAEDFVEVHLPDVHKQVSDVDLGLPSWGKYLLMSAGALATLILAIFLITCCRRANRTKSTQRGHRESGGKV
SVAPQNGKIISSWELYKSESETGM
524
Not Available
Not Available
11-10-2004
Evidence at protein level
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
---|---|---|---|---|---|
Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
---|---|---|
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
Not Available
♦ Virion membrane
♦ Single-pass type I membrane protein .
♦ Single-pass type I membrane protein .
Not Available
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available