Reviewed
Amblyomma Variegatum (Tropical Bont Tick) [TaxID: 34610]; Homo Sapiens (Human) [TaxID: 9606]; Hyalomma Rufipes [TaxID: 72862]; Hyalomma Truncatum [TaxID: 72855]; Rhipicephalus [TaxID: 34630]; Rhipicephalus Annulatus [TaxID: 34611]; Rhipicephalus Decoloratus (African Blue Tick) (Boophilus Decoloratus) [TaxID: 60189]; Rhipicephalus Geigyi [TaxID: 136141]
L
♦RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Includes: Ubiquitin thioesterase (EC 3.4.19.12)
♦ RNA-directed RNA polymerase (EC 2.7.7.48)]
♦ RNA-directed RNA polymerase (EC 2.7.7.48)]
Dugbe Virus (isolate ArD44313) (DUGV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Bunyavirales> Nairoviridae> Orthonairovirus> Dugbe Virus> Dugbe Virus (isolate ArD44313) (DUGV)
Various pathway(s) in which protein is involved
Not Available
Not Available
MDFLDSLIWERVVDEQYITNPTFCVSDYFEVIRQPGDGNCFYHSIAELFFDVKTPSSFRKVKEHLQLAAEVYYDTEPEAVGTGISKDEYIKVAMKDNEWG
GSLEASMLSKHLQTTIILWVVNSTEQVTAAIKFGPGRVSTALNLMHVGRTHFDALRIIEQLENNQPQDRNRLDIADRIAAAEVYVRQSIEDNLQEDEFFD
YAREDEISEDVSAPGGSREATELKKKAILLNKTVKRGENIPIRVGRVLDCLFSCKIAVSLDEGLLYLRPETRESEATSISLRQLGHKLLTRDRHIKMEYA
RSKLYVTRDLIDHLDIGGLLRSSFPGLGLERYIQLLHSELVLDLVTVVLAVLLSTFLYGSNNKNKKQFITNCLLNTKLSGKRVFKALSKLTGQMLYRTPK
RAVSIVSQELYGKLMLKVKNNLEGMGPISMLALRNLNFDNMQLQDYLEMLSEMSKIDNSDVEYTHREISDLHTLVERLSKLQKSQDVNELKLWFKEEVLT
KRSQRSVGNAFEFLINDYFKKKDIMKFVSTSGKASSTGNIGNVLSYAHNLYLSKESLRMTSEDVTQLLIEIRKLHKLQGDLSIEPVAIICDKLEDQFRKL
FRELPEECSSECQTLFNDIRNSPSHSVAWKHALRLKGTAYEGMFAKQYGWSYISEDIKPSLTMIVQTLFPESFEAFLDRTQLHPEFRDLTPDYALTQKIF
FPRNTIPRTENRQLAIDVSLEGSVEAVPIVEKRMFPLPEVPIGEANSISRVMNIFKEKREESMQKKLEHDRQAEANRLKSAGLSASKAEQEVCNSAQDRK
EEKERTTEPAGKQQRTEDLVVIEGNQDEGDSDPQKKVDEKTVPGESKQHSKSSGSSSTNQMSQKVVDVPSVEDSSDQAPGDFPDYGYYFKRIVMDESGTV
LTEEAQLEKRQLLFIEVGYQTDVDGKITTDYKKWKDILRLLELLNIKCSFIACADCSSTPSNNWWISEDKVRLLKNSISHLFSKLTQNSPADVTDIVVGS
ISTQKVRSYLKSGTATKTPISLKDVQETWSKMKDYIVNRPTGISLNKELVGALYQGLVEGAIISKEGTVNLIQMLKDKQERITDEFERTKLKHEVNEDVK
TSEKLLLGWLMEDLKGCRCMGCLTKIKELSESMSVNQDRLEYLSTNCQTKSHCTECHPRSLEYRNISNVDNRVPSMQRVSHSRNEGFEDTNETLTELDRL
VRLTLPGKTEKERRVKRNVEGLIRFMMQQSSLDCIKLPSGQIIAHRCSKKFKNSSEAEEKCNERFERLMKELSEQKLKPYSDHVRKTITSSLKKTDKQAG
SKCAVPRLWLETLIRDLRVPTKDEEILLNIRTSMQSKTNFIRNNDKLIIRSNKEIADYLETKRKNLLSEKASDKIFSSDCILFKEVIAEALRRYYSTPYE
GVPETIVKLINFLCTFGWFQEVVLYSKICETFLRCCTEFSRSGIKLVKVRHCDTNLSIKLPSNKKENMLCCLYDKNMSLLKGPFFLNRRQAILGSAYPYI
LITLYIQVLQQHRCLEVLNSVNDRVVGNINTCTSNLLNTVKAELTLVNSGLFEKAYECRTEQCRLGGNFLNRSSRDHFISTVSGLNVVYGALIKDNLLAN
SQPQNKQLQMLRFGMLCGLSRLSSALELGKKFSTSCRRIEDNIMRLYLQSTIYSANRDVSQNVQNWKMKDLCPDITIPCFSVYGLFVNSDRQRIFDIYNV
HIYNKEMDNFDEGCITVLEETAERHMLWELDLLRSLEGDTRDVRAARLLLGCPNIRKATDKDGNRLMKKGITDDWREEAGSDSSSISGRRSYASSGTRVK
SMFGKYNSSQKPFELKPGLEVVNDPLHDYKQAVQDSFCYSEYTPNTESVLKDCIHIIRTNPSHTMGSYELIQAVTENARRKYPPENIERARKDPKNWVSI
SEVTETTSIVSQPRTHFMLKDCYKVLLGTENKKIVKMLRGKLKKLGAMRTDIEIGKKDCLDLLTTVDGLSEEQCKNIVNGIFEPSKLSFYHWKDLLKKEL
SEVLLTDDGNYIYCWLKTLSSMVKHSLKKDLRFMTGKNSLDIKPEMFTDEEYSALNIMKLELLGEHTDGIQGKTDFLLSSWKKCALKPKEGQSILNVGLN
SLAALHDELYDIRLQHLELTRIKKENPTVSFTKEEILVKRLEKGFLNKYKKEVMEAVNLIFYCCLTAPWCLHYKSLEAYLVRHPEILETECIKENDIPLL
DLTVTSLIRSLIDDIEGESSFNDSSDIKVRFAVKYLITLFTANGEPFSLSLNDGGLNDDLQLTTDEKLLYQTKKVFAKLGLSGNNYDFIWTLQMIANSNF
NVCKRLTGRTTGERLPRSVRSKVIYEMVKLVGETGMAILQQLAFSQALNYDHRFYAVLAPKAQLGGSRDLLVQETGTKVIHATTEMFSRNLLKTTSDDGL
TNPHLKETRLNIGLDMLSTARALDGKQVSDDSNLLNFFKTVCISGDNTKWGPIHCCSFFSGMMQQLLKDVQDWSSFYKLTFIKNLCRQIEIPAPSIRKIL
NVLRFKLSDKGGVEKLSEEAIRSELINNLAEWEGNDTVKFLITTYISKGIMAMNSYNHMGQGIHHATSSLLTSMMAETFEELAVDYMKKHFPGLTVNVDH
AGSSDDYAKCIIVSGLVSKDMYKRYDGVFWRHMCRLKNFLAAVRRCCQMKDSAKTLVGDCFLEFYSEFMMGNRVTPAVIKFIFTGLINSSVTSPQSLVQA
CHVSSQQGMYNSVPLVTNAAFTILRQQIFYNHVEDFIRRYGLITLGAVSPFGRLFLPRFSGLVSSSVALEDSETISKAAAEINSNDIFFNTSSLSNLDKL
EQSPDSSGLDDDSVVSTTTVESSDSKGSSSSFTFDLNRPLSETEVKFLKLLRELTSTTACEMLQEKINTLYNDSREGPLDRHNILQNCRLSESCDWLLDG
KKRGLLELSRRMSCLLNVLIAGYYRSFGSEGTEKQVKASWSRDDNRVIEDPMIQLIPEKLRRELERLGLSRMEVDELMPAVGPDESLSQLVAKKLISLNV
STEEYSAEVSRLKQTLTARNVLHGLAGGIKELSLPIYTIFMKPYFFKDNVFLDLEDRWSSRHSTNYRDSTGKMLTGKVVTKFTHWLDTFLSCVVSANRSQ
EIKECSLFNPNLRCVNIMVKGNGIKELSYIRSHLSVLSVEFENLNLQFSDVNRQKLKIVESRPPECELEANKAVIIKSKLFSAVEHVRLSNNPAVVMGYL
LEESSISEVKPTKVDFSNLLKHRFKLMQFFPSVFTLLRSLQSESKELEKLGEPVDMHQVSKYANHLTLLCRMIQQSKPSLTVFYMLKGSQMNTEPTVSEL
VSYGIKEGRFLKLPEIGLDASTYSVRYWKILHCISAIGELPLSSEDKTSLLISFLNWKVTSDCVDDCCPLEKYDKAIVSEFSGQVLINTLASELSSVRKD
QEREGLTDLIDYINSPSELLKKKPYLGTTCRFQCWGEGAKSGKFTYSSRTGEAIGIFVAGKLHIHLTSDSPGLLCEVERQVLSWLGKRRTDVLTKEQHQF
FLDFLPNLSEVVQKNRDGAILGVTIDSTNVRMLKYVPPKRNTPVIKIKKQILTVKKQTTLDVESEPRIVWGHGQLSIVYDECETETTYHENLIKVKKLVD
LASGTTDKLPTAIFSDTRITLARVKFKTELLLNSLCLLHCFLKHTSQDAIQEVESKCNVLERYLRSGGVQFRPMSESLDKKVTKLPLQCQSDKDVDKEIN
FCEDLTRVFSNENVPLSSWSEVQSYIEEVGFGNVLVHIEKNPTRSDLIWRFSIDSISGNFGPIKDIRTLVTYMSTETVPKFLLPFLLFEEQLKHLIAGCV
ELRDALNSSGINDREIAIVALFTCFYYQSDSVKRQGPVCSISSFCSLIGDDLLPLDNRLQARVLPEQDNVKLHFKLNLTTDSALGKKDKAIQAKKIISRY
LRLIFTEDDMDLKRLKSDATKVKLSSEKECEFLEFCLHSDLSYALNYRVLLEHLIDLEDRAKKTACVLIEEFILMLTGRLMISSTIDSDSKRTLEDDALC
LEDLLDSDNEASSSKSDNEEQIALQTGKFNFNWDSD
GSLEASMLSKHLQTTIILWVVNSTEQVTAAIKFGPGRVSTALNLMHVGRTHFDALRIIEQLENNQPQDRNRLDIADRIAAAEVYVRQSIEDNLQEDEFFD
YAREDEISEDVSAPGGSREATELKKKAILLNKTVKRGENIPIRVGRVLDCLFSCKIAVSLDEGLLYLRPETRESEATSISLRQLGHKLLTRDRHIKMEYA
RSKLYVTRDLIDHLDIGGLLRSSFPGLGLERYIQLLHSELVLDLVTVVLAVLLSTFLYGSNNKNKKQFITNCLLNTKLSGKRVFKALSKLTGQMLYRTPK
RAVSIVSQELYGKLMLKVKNNLEGMGPISMLALRNLNFDNMQLQDYLEMLSEMSKIDNSDVEYTHREISDLHTLVERLSKLQKSQDVNELKLWFKEEVLT
KRSQRSVGNAFEFLINDYFKKKDIMKFVSTSGKASSTGNIGNVLSYAHNLYLSKESLRMTSEDVTQLLIEIRKLHKLQGDLSIEPVAIICDKLEDQFRKL
FRELPEECSSECQTLFNDIRNSPSHSVAWKHALRLKGTAYEGMFAKQYGWSYISEDIKPSLTMIVQTLFPESFEAFLDRTQLHPEFRDLTPDYALTQKIF
FPRNTIPRTENRQLAIDVSLEGSVEAVPIVEKRMFPLPEVPIGEANSISRVMNIFKEKREESMQKKLEHDRQAEANRLKSAGLSASKAEQEVCNSAQDRK
EEKERTTEPAGKQQRTEDLVVIEGNQDEGDSDPQKKVDEKTVPGESKQHSKSSGSSSTNQMSQKVVDVPSVEDSSDQAPGDFPDYGYYFKRIVMDESGTV
LTEEAQLEKRQLLFIEVGYQTDVDGKITTDYKKWKDILRLLELLNIKCSFIACADCSSTPSNNWWISEDKVRLLKNSISHLFSKLTQNSPADVTDIVVGS
ISTQKVRSYLKSGTATKTPISLKDVQETWSKMKDYIVNRPTGISLNKELVGALYQGLVEGAIISKEGTVNLIQMLKDKQERITDEFERTKLKHEVNEDVK
TSEKLLLGWLMEDLKGCRCMGCLTKIKELSESMSVNQDRLEYLSTNCQTKSHCTECHPRSLEYRNISNVDNRVPSMQRVSHSRNEGFEDTNETLTELDRL
VRLTLPGKTEKERRVKRNVEGLIRFMMQQSSLDCIKLPSGQIIAHRCSKKFKNSSEAEEKCNERFERLMKELSEQKLKPYSDHVRKTITSSLKKTDKQAG
SKCAVPRLWLETLIRDLRVPTKDEEILLNIRTSMQSKTNFIRNNDKLIIRSNKEIADYLETKRKNLLSEKASDKIFSSDCILFKEVIAEALRRYYSTPYE
GVPETIVKLINFLCTFGWFQEVVLYSKICETFLRCCTEFSRSGIKLVKVRHCDTNLSIKLPSNKKENMLCCLYDKNMSLLKGPFFLNRRQAILGSAYPYI
LITLYIQVLQQHRCLEVLNSVNDRVVGNINTCTSNLLNTVKAELTLVNSGLFEKAYECRTEQCRLGGNFLNRSSRDHFISTVSGLNVVYGALIKDNLLAN
SQPQNKQLQMLRFGMLCGLSRLSSALELGKKFSTSCRRIEDNIMRLYLQSTIYSANRDVSQNVQNWKMKDLCPDITIPCFSVYGLFVNSDRQRIFDIYNV
HIYNKEMDNFDEGCITVLEETAERHMLWELDLLRSLEGDTRDVRAARLLLGCPNIRKATDKDGNRLMKKGITDDWREEAGSDSSSISGRRSYASSGTRVK
SMFGKYNSSQKPFELKPGLEVVNDPLHDYKQAVQDSFCYSEYTPNTESVLKDCIHIIRTNPSHTMGSYELIQAVTENARRKYPPENIERARKDPKNWVSI
SEVTETTSIVSQPRTHFMLKDCYKVLLGTENKKIVKMLRGKLKKLGAMRTDIEIGKKDCLDLLTTVDGLSEEQCKNIVNGIFEPSKLSFYHWKDLLKKEL
SEVLLTDDGNYIYCWLKTLSSMVKHSLKKDLRFMTGKNSLDIKPEMFTDEEYSALNIMKLELLGEHTDGIQGKTDFLLSSWKKCALKPKEGQSILNVGLN
SLAALHDELYDIRLQHLELTRIKKENPTVSFTKEEILVKRLEKGFLNKYKKEVMEAVNLIFYCCLTAPWCLHYKSLEAYLVRHPEILETECIKENDIPLL
DLTVTSLIRSLIDDIEGESSFNDSSDIKVRFAVKYLITLFTANGEPFSLSLNDGGLNDDLQLTTDEKLLYQTKKVFAKLGLSGNNYDFIWTLQMIANSNF
NVCKRLTGRTTGERLPRSVRSKVIYEMVKLVGETGMAILQQLAFSQALNYDHRFYAVLAPKAQLGGSRDLLVQETGTKVIHATTEMFSRNLLKTTSDDGL
TNPHLKETRLNIGLDMLSTARALDGKQVSDDSNLLNFFKTVCISGDNTKWGPIHCCSFFSGMMQQLLKDVQDWSSFYKLTFIKNLCRQIEIPAPSIRKIL
NVLRFKLSDKGGVEKLSEEAIRSELINNLAEWEGNDTVKFLITTYISKGIMAMNSYNHMGQGIHHATSSLLTSMMAETFEELAVDYMKKHFPGLTVNVDH
AGSSDDYAKCIIVSGLVSKDMYKRYDGVFWRHMCRLKNFLAAVRRCCQMKDSAKTLVGDCFLEFYSEFMMGNRVTPAVIKFIFTGLINSSVTSPQSLVQA
CHVSSQQGMYNSVPLVTNAAFTILRQQIFYNHVEDFIRRYGLITLGAVSPFGRLFLPRFSGLVSSSVALEDSETISKAAAEINSNDIFFNTSSLSNLDKL
EQSPDSSGLDDDSVVSTTTVESSDSKGSSSSFTFDLNRPLSETEVKFLKLLRELTSTTACEMLQEKINTLYNDSREGPLDRHNILQNCRLSESCDWLLDG
KKRGLLELSRRMSCLLNVLIAGYYRSFGSEGTEKQVKASWSRDDNRVIEDPMIQLIPEKLRRELERLGLSRMEVDELMPAVGPDESLSQLVAKKLISLNV
STEEYSAEVSRLKQTLTARNVLHGLAGGIKELSLPIYTIFMKPYFFKDNVFLDLEDRWSSRHSTNYRDSTGKMLTGKVVTKFTHWLDTFLSCVVSANRSQ
EIKECSLFNPNLRCVNIMVKGNGIKELSYIRSHLSVLSVEFENLNLQFSDVNRQKLKIVESRPPECELEANKAVIIKSKLFSAVEHVRLSNNPAVVMGYL
LEESSISEVKPTKVDFSNLLKHRFKLMQFFPSVFTLLRSLQSESKELEKLGEPVDMHQVSKYANHLTLLCRMIQQSKPSLTVFYMLKGSQMNTEPTVSEL
VSYGIKEGRFLKLPEIGLDASTYSVRYWKILHCISAIGELPLSSEDKTSLLISFLNWKVTSDCVDDCCPLEKYDKAIVSEFSGQVLINTLASELSSVRKD
QEREGLTDLIDYINSPSELLKKKPYLGTTCRFQCWGEGAKSGKFTYSSRTGEAIGIFVAGKLHIHLTSDSPGLLCEVERQVLSWLGKRRTDVLTKEQHQF
FLDFLPNLSEVVQKNRDGAILGVTIDSTNVRMLKYVPPKRNTPVIKIKKQILTVKKQTTLDVESEPRIVWGHGQLSIVYDECETETTYHENLIKVKKLVD
LASGTTDKLPTAIFSDTRITLARVKFKTELLLNSLCLLHCFLKHTSQDAIQEVESKCNVLERYLRSGGVQFRPMSESLDKKVTKLPLQCQSDKDVDKEIN
FCEDLTRVFSNENVPLSSWSEVQSYIEEVGFGNVLVHIEKNPTRSDLIWRFSIDSISGNFGPIKDIRTLVTYMSTETVPKFLLPFLLFEEQLKHLIAGCV
ELRDALNSSGINDREIAIVALFTCFYYQSDSVKRQGPVCSISSFCSLIGDDLLPLDNRLQARVLPEQDNVKLHFKLNLTTDSALGKKDKAIQAKKIISRY
LRLIFTEDDMDLKRLKSDATKVKLSSEKECEFLEFCLHSDLSYALNYRVLLEHLIDLEDRAKKTACVLIEEFILMLTGRLMISSTIDSDSKRTLEDDALC
LEDLLDSDNEASSSKSDNEEQIALQTGKFNFNWDSD
4036
Not Available
Not Available
01-11-1996
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Displays RNA-directed RNA polymerase and deubiquitinating activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity (By similarity).
3.4.19.12 , 2.7.7.48
GO:0000166 ; GO:0003968 ; GO:0006351 ; GO:0036459 ; GO:0039502 ;
GO:0039579 ; GO:0039648 ; GO:0039689 ; GO:0039696
GO:0039579 ; GO:0039648 ; GO:0039689 ; GO:0039696
Not Available
♦DOMAIN 29 158 OTU.
♦ DOMAIN 2424 2639 RdRp catalytic.
♦ DOMAIN 2424 2639 RdRp catalytic.
Not Available
X-ray crystallography (1)
♦ACT_SITE 40 40 For ubiquitin thioesterase activity.
♦ ACT_SITE 151 151 For ubiquitin thioesterase activity.
♦ ACT_SITE 151 151 For ubiquitin thioesterase activity.
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available