Reviewed
Epomops Franqueti (Franquet's Epauleted Fruit Bat) [TaxID: 77231]; Homo Sapiens (Human) [TaxID: 9606]; Myonycteris Torquata (Little Collared Fruit Bat) [TaxID: 77243]
L[Gene ID: 3160771 ]
♦RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
Sudan Ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola Virus)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Filoviridae> Ebolavirus> Sudan Ebolavirus> Sudan Ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola Virus)
Not Available
Various pathway(s) in which protein is involved
Not Available
MMATQHTQYPDARLSSPIVLDQCDLVTRACGLYSEYSLNPKLKTCRLPKHIYRLKYDTIVLRFISDVPVATIPIDYIAPMLINVLADSKNVPLEPPCLSF
LDEIVNYTVQDAAFLNYYMNQIKTQEGVITDQLKQNIRRVIHKNRYLSALFFWHDLAILTRRGRMNRGNVRSTWFVTNEVVDILGYGDYIFWKIPIALLP
MNTANVPHASTDWYQPNIFKEAIQGHTHIISVSTAEVLIMCKDLVTSRFNTLLIAELARLEDPVSADYPLVDNIQSLYNAGDYLLSILGSEGYKIIKYLE
PLCLAKIQLCSQYTERKGRFLTQMHLAVIQTLRELLLNRGLKKSQLSKIREFHQLLLRLRSTPQQLCELFSIQKHWGHPVLHSEKAIQKVKNHATVLKAL
RPIIIFETYCVFKYSVAKHFFDSQGTWYSVISDRCLTPGLNSYIRRNQFPPLPMIKDLLWEFYHLDHPPLFSTKIISDLSIFIKDRATAVEQTCWDAVFE
PNVLGYSPPYRFNTKRVPEQFLEQEDFSIESVLQYAQELRYLLPQNRNFSFSLKEKELNVGRTFGKLPYLTRNVQTLCEALLADGLAKAFPSNMMVVTER
EQKESLLHQASWHHTSDDFGEHATVRGSSFVTDLEKYNLAFRYEFTAPFIKYCNQCYGVRNVFDWMHFLIPQCYMHVSDYYNPPHNVTLENREYPPEGPS
AYRGHLGGIEGLQQKLWTSISCAQISLVEIKTGFKLRSAVMGDNQCITVLSVFPLESSPNEQERCAEDNAARVAASLAKVTSACGIFLKPDETFVHSGFI
YFGKKQYLNGIQLPQSLKTAARMAPLSDAIFDDLQGTLASIGTAFERSISETRHILPCRVAAAFHTYFSVRILQHHHLGFHKGSDLGQLAINKPLDFGTI
ALSLAVPQVLGGLSFLNPEKCLYRNLGDPVTSGLFQLKHYLSMVGMSDIFHALIAKSPGNCSAIDFVLNPGGLNVPGSQDLTSFLRQIVRRSITLSARNK
LINTLFHASADLEDELVCKWLLSSTPVMSRFAADIFSRTPSGKRLQILGYLEGTRTLLASKMISNNAETPILERLRKITLQRWNLWFSYLDHCDPALMEA
IQPIKCTVDIAQILREYSWAHILDGRQLIGATLPCIPEQFQTTWLKPYEQCVECSSTNNSSPYVSVALKRNVVSAWPDASRLGWTIGDGIPYIGSRTEDK
IGQPAIKPRCPSAALREAIELTSRLTWVTQGSANSDQLIRPFLEARVNLSVQEILQMTPSHYSGNIVHRYNDQYSPHSFMANRMSNTATRLMVSTNTLGE
FSGGGQAARDSNIIFQNVINFAVALYDIRFRNTCTSSIQYHRAHIHLTNCCTREVPAQYLTYTTTLNLDLSKYRNNELIYDSDPLRGGLNCNLSIDSPLM
KGPRLNIIEDDLIRLPHLSGWELAKTVLQSIISDSSNSSTDPISSGETRSFTTHFLTYPKIGLLYSFGALISFYLGNTILCTKKIGLTEFLYYLQNQIHN
LSHRSLRIFKPTFRHSSVMSRLMDIDPNFSIYIGGTAGDRGLSDAARLFLRIAISTFLSFVEEWVIFRKANIPLWVIYPLEGQRSDPPGEFLNRVKSLIV
GTEDDKNKGSILSRSGEKCSSNLVYNCKSTASNFFHASLAYWRGRHRPKKTIGATNATTAPHIILPLGNSDRPPGLDLNRNNDTFIPTRIKQIVQGDSRN
DRTTTTRFPPKSRSTPTSATEPPTKMYEGSTTHQGKLTDTHLDEDHNAKEFPSNPHRLVVPFFKLTKDGEYSIEPSPEESRSNIKGLLQHLRTMVDTTIY
CRFTGIVSSMHYKLDEVLWEYNKFESAVTLAEGEGSGALLLIQKYGVKKLFLNTLATEHSIESEVISGYTTPRMLLPIMPKTHRGELEVILNNSASQITD
ITHRDWFSNQKNRIPNDADIITMDAETTENLDRSRLYEAVYTIICNHINPKTLKVVILKVFLSDLDGMCWINNYLAPMFGSGYLIKPITSSAKSSEWYLC
LSNLLSTLRTTQHQTQANCLHVVQCALQQQVQRGSYWLSHLTKYTTSRLHNSYIAFGFPSLEKVLYHRYNLVDSRNGPLVSITRHLALLQTEIRELVTDY
NQLRQSRTQTYHFIKTSKGRITKLVNDYLRFELVIRALKNNSTWHHELYLLPELIGVCHRFNHTRNCTCSERFLVQTLYLHRMSDAEIKLMDRLTSLVNM
FPEGFRSSSV
LDEIVNYTVQDAAFLNYYMNQIKTQEGVITDQLKQNIRRVIHKNRYLSALFFWHDLAILTRRGRMNRGNVRSTWFVTNEVVDILGYGDYIFWKIPIALLP
MNTANVPHASTDWYQPNIFKEAIQGHTHIISVSTAEVLIMCKDLVTSRFNTLLIAELARLEDPVSADYPLVDNIQSLYNAGDYLLSILGSEGYKIIKYLE
PLCLAKIQLCSQYTERKGRFLTQMHLAVIQTLRELLLNRGLKKSQLSKIREFHQLLLRLRSTPQQLCELFSIQKHWGHPVLHSEKAIQKVKNHATVLKAL
RPIIIFETYCVFKYSVAKHFFDSQGTWYSVISDRCLTPGLNSYIRRNQFPPLPMIKDLLWEFYHLDHPPLFSTKIISDLSIFIKDRATAVEQTCWDAVFE
PNVLGYSPPYRFNTKRVPEQFLEQEDFSIESVLQYAQELRYLLPQNRNFSFSLKEKELNVGRTFGKLPYLTRNVQTLCEALLADGLAKAFPSNMMVVTER
EQKESLLHQASWHHTSDDFGEHATVRGSSFVTDLEKYNLAFRYEFTAPFIKYCNQCYGVRNVFDWMHFLIPQCYMHVSDYYNPPHNVTLENREYPPEGPS
AYRGHLGGIEGLQQKLWTSISCAQISLVEIKTGFKLRSAVMGDNQCITVLSVFPLESSPNEQERCAEDNAARVAASLAKVTSACGIFLKPDETFVHSGFI
YFGKKQYLNGIQLPQSLKTAARMAPLSDAIFDDLQGTLASIGTAFERSISETRHILPCRVAAAFHTYFSVRILQHHHLGFHKGSDLGQLAINKPLDFGTI
ALSLAVPQVLGGLSFLNPEKCLYRNLGDPVTSGLFQLKHYLSMVGMSDIFHALIAKSPGNCSAIDFVLNPGGLNVPGSQDLTSFLRQIVRRSITLSARNK
LINTLFHASADLEDELVCKWLLSSTPVMSRFAADIFSRTPSGKRLQILGYLEGTRTLLASKMISNNAETPILERLRKITLQRWNLWFSYLDHCDPALMEA
IQPIKCTVDIAQILREYSWAHILDGRQLIGATLPCIPEQFQTTWLKPYEQCVECSSTNNSSPYVSVALKRNVVSAWPDASRLGWTIGDGIPYIGSRTEDK
IGQPAIKPRCPSAALREAIELTSRLTWVTQGSANSDQLIRPFLEARVNLSVQEILQMTPSHYSGNIVHRYNDQYSPHSFMANRMSNTATRLMVSTNTLGE
FSGGGQAARDSNIIFQNVINFAVALYDIRFRNTCTSSIQYHRAHIHLTNCCTREVPAQYLTYTTTLNLDLSKYRNNELIYDSDPLRGGLNCNLSIDSPLM
KGPRLNIIEDDLIRLPHLSGWELAKTVLQSIISDSSNSSTDPISSGETRSFTTHFLTYPKIGLLYSFGALISFYLGNTILCTKKIGLTEFLYYLQNQIHN
LSHRSLRIFKPTFRHSSVMSRLMDIDPNFSIYIGGTAGDRGLSDAARLFLRIAISTFLSFVEEWVIFRKANIPLWVIYPLEGQRSDPPGEFLNRVKSLIV
GTEDDKNKGSILSRSGEKCSSNLVYNCKSTASNFFHASLAYWRGRHRPKKTIGATNATTAPHIILPLGNSDRPPGLDLNRNNDTFIPTRIKQIVQGDSRN
DRTTTTRFPPKSRSTPTSATEPPTKMYEGSTTHQGKLTDTHLDEDHNAKEFPSNPHRLVVPFFKLTKDGEYSIEPSPEESRSNIKGLLQHLRTMVDTTIY
CRFTGIVSSMHYKLDEVLWEYNKFESAVTLAEGEGSGALLLIQKYGVKKLFLNTLATEHSIESEVISGYTTPRMLLPIMPKTHRGELEVILNNSASQITD
ITHRDWFSNQKNRIPNDADIITMDAETTENLDRSRLYEAVYTIICNHINPKTLKVVILKVFLSDLDGMCWINNYLAPMFGSGYLIKPITSSAKSSEWYLC
LSNLLSTLRTTQHQTQANCLHVVQCALQQQVQRGSYWLSHLTKYTTSRLHNSYIAFGFPSLEKVLYHRYNLVDSRNGPLVSITRHLALLQTEIRELVTDY
NQLRQSRTQTYHFIKTSKGRITKLVNDYLRFELVIRALKNNSTWHHELYLLPELIGVCHRFNHTRNCTCSERFLVQTLYLHRMSDAEIKLMDRLTSLVNM
FPEGFRSSSV
2210
Not Available
Not Available
23-11-2004
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
2.7.7.48 , 2.1.1.56 , 2.7.7.88 , 2.1.1.296
Host cytoplasm. Virion .
♦DOMAIN 626 810 RdRp catalytic.
♦ DOMAIN 1802 2000 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1802 2000 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available