Results | viHumans

UniProt ID

Q4U0X7

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Tax

Protein Name

Protein Tax-3 (Trans-activating transcriptional regulatory protein of HTLV-3)

Organism Name

Human T-cell Leukemia Virus 3 (strain Pyl43) (HTLV-3)

Taxonomic Lineage

Viruses> Retro-transcribing Viruses> Retroviridae> Orthoretrovirinae> Deltaretrovirus> Primate T-lymphotropic Virus 3> Human T-cell Leukemia Virus 3 (strain Pyl43) (HTLV-3)

RefSeq

Not Available

PubMed ID

16973592

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MAHFPGFGQSLLYGYPVYVFGDCVQADWCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVVSSALQYLIPRLPSFPTQRTTRTLKVLTPPTTATTPK
VPPSFFHAVKKHTPFRNNCLELTLGEQLPAMSFPDPGLRPQNVYTIWGCSVVCLYLYQLSPPMTWPLIPHVIFCHPEQLGAFLTRVPTKRLEELLYKIFL
STGAIIILPENCFPTTLFQPTRAPAIQAPWHTGLLPCQKEIVTPGLIWTFTDGSPMISGPCPKEGQPSLVVQSSTFIFQQFQTKASHPAFLLSHKLIQYS
SFHSLHLLFEEYSTVPFSLLFNEKGANVSDDEPRGGPQPPTGGQIAESSV
						

Length

350

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

17-10-2006

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to two 21 bp repeat elements located within the LTRs, referred to as Tax-responsive element (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Activation of NF-kappa-B leads to up-regulation of the expression of gene promoters containing NFkB motifs like IL8 or BCL2L1. Inhibits the action of p53/TP53 and MYCB. All these functions could lead to the possible occurrence of lymphoproliferative disorders. Required for viral replication.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0006351 ; GO:0017124 ; GO:0030430 ; GO:0039646 ;
GO:0042025 ; GO:0045893 ; GO:0046872

Subcellular Location

Host nucleus . Host cytoplasm . Note=Shuttles from the nucleus to the cytoplasm. Found predominantly in the nucleus, with some cytoplasmic speckles.

Domain(s)

Not Available

Motif(s)

MOTIF 73 80 SH3-binding. ; MOTIF 188 202 Nuclear export signal. ; MOTIF 347 350 PDZ-binding.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available