Reviewed
Homo Sapiens (Human) [TaxID: 9606]
ORF2
♦Capsid polyprotein VP90 [Cleaved into: Capsid polyprotein VP70
♦ Capsid protein VP34
♦ Capsid protein VP27
♦ Capsid protein VP25]
♦ Capsid protein VP34
♦ Capsid protein VP27
♦ Capsid protein VP25]
Human Astrovirus-5 (HAstV-5)
Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Astroviridae> Mamastrovirus> Mamastrovirus 1> Human Astrovirus-5 (HAstV-5)
Not Available
Various pathway(s) in which protein is involved
Not Available
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MASKPSKQVTVEVNNGRSRSRSRPRSQSRGRDKSVKITVNSRNKGRRQNGRNKHQSNQRVRNIVNKQLRKQGVTGPKPAICQRATATLGTVGSNTSGTTE
IEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGSSAVNGTVVRVSLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPADLGG
PRDGWWLTNTNDNASDTLGPSIEIHTLGRTMSSYQNQQFTGGLFLVELASEWCFTGYAANPNLVNLMKSTDKQVNVTFNGSAGEPLVMSVPATSHFVRAV
VARSTLPTSLARAGERTTSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRTRNGTRSFYVYPSYQDALSNKPAICTGGLPSGLRAASAVATT
LQFTQMNQPSLGHGENTATLGRSIATAGDRLKVILTVGQPVTPNENNKQTWVGKTNTPTEEVVKIGVNTQNYNVMNGFTMISSIDWYDEEMQPLEVPVPM
SELLVMKGINKKADVYAAQQYKNSISNNKHQITSVYLVRVKENFQVTNHLSYFFREKVDTTATELMKIRPQTYYTTVNFVQNNWYLLTSTVLHTGSLPSG
WVWMNQELMNNENYIVDQGMKHLMTTPPVSSQLYFEMLTSLPQAMAEHFDQGDQAVVAHDSPGQALFSAEETDSDFESTEDETDEVDRFDLHLSSESDDD
DVENNRVTLLSTLINQGMSVERATRITSNAFPTRAARLRRSVYNDLLVSGLGPDAAWSHACEQARKVGDNHDLQASGSRGHAE
IEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGSSAVNGTVVRVSLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPADLGG
PRDGWWLTNTNDNASDTLGPSIEIHTLGRTMSSYQNQQFTGGLFLVELASEWCFTGYAANPNLVNLMKSTDKQVNVTFNGSAGEPLVMSVPATSHFVRAV
VARSTLPTSLARAGERTTSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRTRNGTRSFYVYPSYQDALSNKPAICTGGLPSGLRAASAVATT
LQFTQMNQPSLGHGENTATLGRSIATAGDRLKVILTVGQPVTPNENNKQTWVGKTNTPTEEVVKIGVNTQNYNVMNGFTMISSIDWYDEEMQPLEVPVPM
SELLVMKGINKKADVYAAQQYKNSISNNKHQITSVYLVRVKENFQVTNHLSYFFREKVDTTATELMKIRPQTYYTTVNFVQNNWYLLTSTVLHTGSLPSG
WVWMNQELMNNENYIVDQGMKHLMTTPPVSSQLYFEMLTSLPQAMAEHFDQGDQAVVAHDSPGQALFSAEETDSDFESTEDETDEVDRFDLHLSSESDDD
DVENNRVTLLSTLINQGMSVERATRITSNAFPTRAARLRRSVYNDLLVSGLGPDAAWSHACEQARKVGDNHDLQASGSRGHAE
783
Not Available
Not Available
19-07-2005
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).
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Virion .
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Predicted/Modelled
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Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
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- Million Molecules
Best 20 Hit molecules
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