Reviewed
Homo Sapiens (Human) [TaxID: 9606]
ORF22
Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
Varicella-zoster Virus (strain Oka Vaccine) (HHV-3) (Human Herpesvirus 3)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Oka Vaccine) (HHV-3) (Human Herpesvirus 3)
Various pathway(s) in which protein is involved
Not Available
Not Available
MDIIPPIAVTVAGVGSRNQFDGALGPASGLSCLRTSLSFLHMTYAHGINATLSSDMIDGCLQEGAAWTTDLSNMGRGVPDMCALVDLPNRISYIKLGDTT
STCCVLSRIYGDSHFFTVPDEGFMCTQIPARAFFDDVWMGREESYTIITVDSTGMAIYRQGNISFIFDPHGHGTIGQAVVVRVNTTDVYSYIASEYTHRP
DNVESQWAAALVFFVTANDGPVSEEALSSAVTLIYGSCDTYFTDEQYCEKLVTAQHPLLLSPPNSTTIVLNKSSIVPLHQNVGESVSLEATLHSTLTNTV
ALDPRCSYSEVDPWHAVLETTSTGSGVLDCRRRRRPSWTPPSSEENLACIDDGLVNNTHSTDNLHKPAKKVLKFKPTVDVPDKTQVAHVLPRLREVANTP
DVVLNVSNVDTPESSPTFSRNMNVGSSLKDRKPFLFEQSGDVNMVVEKLLQHGHEISNGYVQNAVGTLDTVITGHTNVPIWVTRPLVMPDEKDPLELFIN
LTILRLTGFVVENGTRTHHGATSVVSDFIGPLGEILTGFPSAAELIRVTSLILTNMPGAEYAIKTVLRKKCTIGMLIIAKFGLVAMRVQDTTGALHAELD
VLEADLGGSSPIDLYSRLSTGLISILNSPIISHPGLFAELIPTRTGSLSERIRLLCELVSARETRYMREHTALVSSVKALENALRSTRNKIDAIQIPEVP
QEPPEETDIPPEELIRRVYEIRSEVTMLLTSAVTEYFTRGVLYSTRALIAEQSPRRFRVATASTAPIQRLLDSLPEFDAKLTAIISSLSIHPPPETIQNL
PVVSLLKELIKEGEDLNTDTALVSWLSVVGEAQTAGYLSRREFDELSRTIKTINTRATQRASAEAELSCFNTLSAAVDQAVKDYETYNNGEVKYPEITRD
DLLATIVRATDDLVRQIKILSDPMIQSGLQPSIKRRLETRLKEVQTYANEARTTQDTIKSRKQAAYNKLGGLLRPVTGFVGLRAAVDLLPELASELDVQG
ALVNLRTKVLEAPVEIRSQLTGDFWALFNQYRDILEHPGNARTSVLGGLGACFTAIIEIVPIPTEYRPSLLAFFGDVADVLASDIATVSTNPESESAINA
VVATLSKATLVSSTVPALSFVLSLYKKYQALQQEITNTHKLTELQKQLGDDFSTLAVSSGHLKFISSSNVDDYEINDAILSIQTNVHALMDTVKLVEVEL
QKLPPHCIAGTSTLSRVVKDLHKLVTMAHEKKEQAKVLITDCERAHKQQTTRVLYERWTRDIIACLEAMETRHVFNGTELARLRDMAAAGGFDIHAVYPQ
ARQVVAACETTAVTALDTVFRHNPHTPENTNIPPPLALLRGLTWFDDFSITAPVFTVMFPGVSIEGLLLLMRIRAVVLLSADTSINGIPNYRDMILRTSG
DLLQIPALAGYVDFYTRSYDQFITESVTLSELRADIRQAAGAKLTEANKALEEVTHVRAHETAKLALKEGVFITLPSEGLLIRAIEYFTTFDHKRFIGTA
YERVLQTMVDRDLKEANAELAQFRMVCQATKNRAIQILQNIVDTANATEQQEDVDFTNLKTLLKLTPPPKTIALAIDRSTSVQDIVTQFALLLGRLEEET
GTLDIQAVDWMYQARNIIDSHPLSVRIDGTGPLHTYKDRVDKLYALRTKLDLLRRRIETGEVTWDDAWTTFKRETGDMLASGDTYATSVDSIKALQASAS
VVDMLCSEPEFFLLPVETKNRLQKKQQERKTALDVVLQKQRQFEETASRLRALIERIPTESDHDVLRMLLHDFDQFTHLPIWIKTQYMTFRNLLMVRLGL
YASYAEIFPPASPNGVFAPIPAMSGVCLEDQSRCIRARVAAFMGEASVVQTFREARSSIDALFGKNLTFYLDTDGVPLRYRVCYKSVGVKLGTMLCSQGG
LSLRPALPDEGIVEETTLSALRVANEVNELRIEYESAIKSGFSAFSTFVRHRHAEWGKTNARRAIAEIYAGLITTTLTRQYGVHWDKLIYSFEKHHLTSV
MGNGLTKPIQRRGDVRVLELTLSDIVTILVATTPVHLLNFARLDLIKQHEYMARTLRPVIEAAFRGRLLVRSLDGDPKGNARAFFNAAPSKHKLPLALGS
NQDPTGGRIFAFRMADWKLVKMPQKITDPFAPWQLSPPPGVKANVDAVTRIMATDRLATITVLGRMCLPPISLVSMWNTLQPEEFAYRTQDDVDIIVDAR
LDLSSTLNARFDTAPSNTTLEWNTDRKVITDAYIQTGATTVFTVTGAAPTHVSNVTAFDIATTAILFGAPLVIAMELTSVFSQNSGLTLGLKLFDSRHMA
TDSGISSAVSPDIVSWGLRLLHMDPHPIENACLIVQLEKLSALIANKPLTNNPPCLLLLDEHMNPSYVLWERKDSIPAPDYVVFWGPESLIDLPYIDSDE
DSFPSCPDDPFYSQIIAGYAPQGPPNLDTTDFYPTEPLFKSPVQVVRSSKCKKMPVQPVQPAQPVQPAQPAQPVQPAQPIEPGTQIVVQNFKKPQSVKTT
LSQKDIPLYVETESETAVLIPKQLTTSIKTTVCKSITPPNNQLSDWKNNPQQNQTLNQAFNKPILEITSIPTDDSISYRTWIEKSNQTQKRHQNDPRMYN
SKTVFHPVNNQLPSWVDTAADAPQTDLLTNYKTRQPSPNFPRDVHTWGVSSNPFNSPNRDLYESDFSEPSDGYSSESENSIVLSLDEHRSCRVPRHVRVV
NADVVTGRRYVRGTALGALALLSQACRRMIDNVRYTRKLLMDHTEDIFQGLGYVKLLLDGTYI
STCCVLSRIYGDSHFFTVPDEGFMCTQIPARAFFDDVWMGREESYTIITVDSTGMAIYRQGNISFIFDPHGHGTIGQAVVVRVNTTDVYSYIASEYTHRP
DNVESQWAAALVFFVTANDGPVSEEALSSAVTLIYGSCDTYFTDEQYCEKLVTAQHPLLLSPPNSTTIVLNKSSIVPLHQNVGESVSLEATLHSTLTNTV
ALDPRCSYSEVDPWHAVLETTSTGSGVLDCRRRRRPSWTPPSSEENLACIDDGLVNNTHSTDNLHKPAKKVLKFKPTVDVPDKTQVAHVLPRLREVANTP
DVVLNVSNVDTPESSPTFSRNMNVGSSLKDRKPFLFEQSGDVNMVVEKLLQHGHEISNGYVQNAVGTLDTVITGHTNVPIWVTRPLVMPDEKDPLELFIN
LTILRLTGFVVENGTRTHHGATSVVSDFIGPLGEILTGFPSAAELIRVTSLILTNMPGAEYAIKTVLRKKCTIGMLIIAKFGLVAMRVQDTTGALHAELD
VLEADLGGSSPIDLYSRLSTGLISILNSPIISHPGLFAELIPTRTGSLSERIRLLCELVSARETRYMREHTALVSSVKALENALRSTRNKIDAIQIPEVP
QEPPEETDIPPEELIRRVYEIRSEVTMLLTSAVTEYFTRGVLYSTRALIAEQSPRRFRVATASTAPIQRLLDSLPEFDAKLTAIISSLSIHPPPETIQNL
PVVSLLKELIKEGEDLNTDTALVSWLSVVGEAQTAGYLSRREFDELSRTIKTINTRATQRASAEAELSCFNTLSAAVDQAVKDYETYNNGEVKYPEITRD
DLLATIVRATDDLVRQIKILSDPMIQSGLQPSIKRRLETRLKEVQTYANEARTTQDTIKSRKQAAYNKLGGLLRPVTGFVGLRAAVDLLPELASELDVQG
ALVNLRTKVLEAPVEIRSQLTGDFWALFNQYRDILEHPGNARTSVLGGLGACFTAIIEIVPIPTEYRPSLLAFFGDVADVLASDIATVSTNPESESAINA
VVATLSKATLVSSTVPALSFVLSLYKKYQALQQEITNTHKLTELQKQLGDDFSTLAVSSGHLKFISSSNVDDYEINDAILSIQTNVHALMDTVKLVEVEL
QKLPPHCIAGTSTLSRVVKDLHKLVTMAHEKKEQAKVLITDCERAHKQQTTRVLYERWTRDIIACLEAMETRHVFNGTELARLRDMAAAGGFDIHAVYPQ
ARQVVAACETTAVTALDTVFRHNPHTPENTNIPPPLALLRGLTWFDDFSITAPVFTVMFPGVSIEGLLLLMRIRAVVLLSADTSINGIPNYRDMILRTSG
DLLQIPALAGYVDFYTRSYDQFITESVTLSELRADIRQAAGAKLTEANKALEEVTHVRAHETAKLALKEGVFITLPSEGLLIRAIEYFTTFDHKRFIGTA
YERVLQTMVDRDLKEANAELAQFRMVCQATKNRAIQILQNIVDTANATEQQEDVDFTNLKTLLKLTPPPKTIALAIDRSTSVQDIVTQFALLLGRLEEET
GTLDIQAVDWMYQARNIIDSHPLSVRIDGTGPLHTYKDRVDKLYALRTKLDLLRRRIETGEVTWDDAWTTFKRETGDMLASGDTYATSVDSIKALQASAS
VVDMLCSEPEFFLLPVETKNRLQKKQQERKTALDVVLQKQRQFEETASRLRALIERIPTESDHDVLRMLLHDFDQFTHLPIWIKTQYMTFRNLLMVRLGL
YASYAEIFPPASPNGVFAPIPAMSGVCLEDQSRCIRARVAAFMGEASVVQTFREARSSIDALFGKNLTFYLDTDGVPLRYRVCYKSVGVKLGTMLCSQGG
LSLRPALPDEGIVEETTLSALRVANEVNELRIEYESAIKSGFSAFSTFVRHRHAEWGKTNARRAIAEIYAGLITTTLTRQYGVHWDKLIYSFEKHHLTSV
MGNGLTKPIQRRGDVRVLELTLSDIVTILVATTPVHLLNFARLDLIKQHEYMARTLRPVIEAAFRGRLLVRSLDGDPKGNARAFFNAAPSKHKLPLALGS
NQDPTGGRIFAFRMADWKLVKMPQKITDPFAPWQLSPPPGVKANVDAVTRIMATDRLATITVLGRMCLPPISLVSMWNTLQPEEFAYRTQDDVDIIVDAR
LDLSSTLNARFDTAPSNTTLEWNTDRKVITDAYIQTGATTVFTVTGAAPTHVSNVTAFDIATTAILFGAPLVIAMELTSVFSQNSGLTLGLKLFDSRHMA
TDSGISSAVSPDIVSWGLRLLHMDPHPIENACLIVQLEKLSALIANKPLTNNPPCLLLLDEHMNPSYVLWERKDSIPAPDYVVFWGPESLIDLPYIDSDE
DSFPSCPDDPFYSQIIAGYAPQGPPNLDTTDFYPTEPLFKSPVQVVRSSKCKKMPVQPVQPAQPVQPAQPAQPVQPAQPIEPGTQIVVQNFKKPQSVKTT
LSQKDIPLYVETESETAVLIPKQLTTSIKTTVCKSITPPNNQLSDWKNNPQQNQTLNQAFNKPILEITSIPTDDSISYRTWIEKSNQTQKRHQNDPRMYN
SKTVFHPVNNQLPSWVDTAADAPQTDLLTNYKTRQPSPNFPRDVHTWGVSSNPFNSPNRDLYESDFSEPSDGYSSESENSIVLSLDEHRSCRVPRHVRVV
NADVVTGRRYVRGTALGALALLSQACRRMIDNVRYTRKLLMDHTEDIFQGLGYVKLLLDGTYI
2763
Not Available
Not Available
22-09-2009
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.
3.4.19.12 , 3.4.22.-
Virion tegument . Host cytoplasm . Host nucleus . Note=Tightly associated with the capsid. .
DOMAIN 12 237 Peptidase C76.
Not Available
Predicted/Modelled
Not Available
♦ACT_SITE 32 32
♦ ACT_SITE 168 168
♦ ACT_SITE 170 170
♦ ACT_SITE 168 168
♦ ACT_SITE 170 170
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available