Results | viHumans

UniProt ID

Q49PZ0

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

P28 mO008R

Protein Name

E3 ubiquitin ligase p28-like (EC 2.3.2.-) (E3 ubiquitin transferase p28-like)

Organism Name

Vaccinia Virus (strain LC16m0) (VACV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Vaccinia Virus> Vaccinia Virus (strain LC16m0) (VACV)

RefSeq

NC_006998.1 ; AY243312.1

PubMed ID

16140764

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MEFDPAKINTSSIDHVTILQYIDEPNDIRLTVCIIRNINNITYYINITKINTHLANQFRAWKKRIAGRDYITNLSRDTGIQQSKLTETIRNCQKNRNIYG
LYIHYNLVINVVIDWITDVIVQSILRGLVNWYIANNTYTPNNTTTISELDIIKILDKYEDVYRVSKEKECGICYEVVYSKRLENDRYFGLLDSCNHIFCI
TCINIWHKTRRETGASDNCPICRTRFRNITMSKFYKLVN
						

Length

239

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

13-09-2005

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

RING-finger E3 ubiquitin ligase which catalyzes the formation of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Plays an important role in virulence by acting as an anti-apoptotic factor (By similarity).

EC

2.3.2.-

Experimentally known GO terms

GO:0016740 ; GO:0016881 ; GO:0030430 ; GO:0039526 ; GO:0039648 ;
GO:0046872

Subcellular Location

Host cytoplasm. Note=Localizes to viral factories, the sites of virus replication. .

Domain(s)

DOMAIN 21 131 KilA-N.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available