Results | viHumans

UniProt ID

Q3KSV2

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

EBNA2 BYRF1

Protein Name

Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

Organism Name

Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

16306603

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MPTFYLALHGGQTYHLIVDTDSVGNPSLSVIPSNPYQEQLSDTPLIPLTIFVGENTGVPPPPPPPPQRRDAWTQEPSPLDWDPLGYDVGHGPLASAMRML
WMANYIVRQSRGDRGLILPQGPQTAPQAMLVQPHVPPLRPTAPTILSPLSQPRLTPPQPLMMPPRPTPPTPLPPATLTVPPRPTRPTTLPPTPLLTVLQR
PTELQPTPSPPRMHLPVLHVPDQSMHPLTHQSTPNDPDSPEPRSPTVFYNIPPMPLPPSQLPPPAAPAQPPPGVINDQQLHHLPSGPPWWPPICDPPQPS
KTQGQSRGQSRGRGRGRGRGRGKSRDKQRKPGGPWRPEPNTSSPSMPELSPVLGLHQGQGAGDSPTPGPSNAAPVCRNSHTATPNVSPIHEPESHNSPEA
PILFPDDWYPPSIDPADLDESWDYIFETTESPSSDEDYVEGPSKRPRPSIQ
						

Length

451

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

08-11-2005

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0006351 ; GO:0006355 ; GO:0039502 ; GO:0039586 ; GO:0044204 ;
GO:0060153

Subcellular Location

Host nucleus matrix. Note=Associated with the nuclear matrix. .

Domain(s)

Not Available

Motif(s)

MOTIF 347 351 PXLXP motif, interaction with host ZMYND11. ; MOTIF 401 405 PXLXP motif, interaction with host ZMYND11.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available