Results | viHumans

UniProt ID

Q2KS10

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

L2

Protein Name

Pre-core protein X (pX) (11 kDa core protein) (Protein mu) (pMu) [Cleaved into: Core protein X]

Organism Name

Human Adenovirus C Serotype 5 (HAdV-5) (Human Adenovirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus C> Human Adenovirus C Serotype 5 (HAdV-5) (Human Adenovirus 5)

RefSeq

AC_000008.1 ;

PubMed ID

1727603 ; 16481660 ; 23142869 ; 22754652 ; 22116065

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MALTCRLRFPVPGFRGRMHRRRGMAGHGLTGGMRRAHHRRRRASHRRMRGGILPLLIPLIAAAIGAVPGIASVALQAQRH
						

Length

80

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

07-03-2006

Protein Existence

Evidence at transcript level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Pre-core protein X: Interacts with the viral DNA and aids in tightly condensing it within the capsid. Cleavage of pre-core protein X may serve to partially relax this structure within the mature virion prior to its entry into the nucleus (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0019013 ; GO:0044196

Subcellular Location

♦ Pre-core protein X: Host nucleus, host nucleolus . Note=Excluded from adenovirus DNA-binding protein (DBP)-rich replication centers in adenovirus-infected cells.
♦ Core protein X: Virion. Note=Located inside the capsid in association with the viral DNA (core). Present in about 126-160 copies per virion. Excluded from adenovirus DNA-binding protein (DBP)-rich replication centers in adenovirus-infected cells (By similarity). .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available