Results | viHumans

UniProt ID

Q2HRD4

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

ORF4[Gene ID: 4961488 ]

Protein Name

Complement control protein (KCP)

Organism Name

Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Rhadinovirus> Human Herpesvirus 8 (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)> Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)

RefSeq

NC_009333.1 ; AF148805.2

PubMed ID

10400794 ; 16760382 ; 12477863 ; 15304516 ; 16571823

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:4961488

Reactome

Not Available

Sequence

							MAFLRQTLWILWTFTMVIGQDNEKCSQKTLIGYRLKMSRDGDIAVGETVELRCRSGYTTYARNITATCLQGGTWSEPTATCNKKSCPNPGEIQNGKVIFH
GGQDALKYGANISYVCNEGYFLVGREYVRYCMIGASGQMAWSSSPPFCEKEKCHRPKIENGDFKPDKDYYEYNDAVHFECNEGYTLVGPHSIACAVNNTW
TSNMPTCELAGCKFPSVTHGYPIQGFSLTYKHKQSVTFACNDGFVLRGSPTITCNVTEWDPPLPKCVLEDIDDPNNSNPGRLHPTPNEKPNGNVFQRSNY
TEPPTKPEDTHTAATCDTNCEQPPKILPTSEGFNETTTSNTITKQLEDEKTTSQPNTHITSALTSMKAKGNFTNKTNNSTDLHIASTPTSQDDATPSIPS
VQTPNYNTNAPTRTLTSLHIEEGPSNSTTSEKATASTLSHNSHKNDTGGIYTTLNKTTQLPSTNKPTNSQAKSSTKPRVETHNKTTSNPAISLTDSADVP
QRPREPTLPPIFRPPASKNRYLEKQLVIGLLTAVALTCGLITLFHYLFFR
						

Length

550

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

21-03-2006

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Inhibits the complement component of the host innate immune response. Regulates host C3 convertases, accelerating their decay, and acts as a cofactor for factor I degradation of C4b and C3b. Binds also heparin, and therefore may play two distinct roles when incorporated in virion membranes: immune evasion and host cell binding.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0033644 ; GO:0039573 ; GO:0055036

Subcellular Location

♦ Host membrane
♦ Single-pass type I membrane protein . Virion membrane .

Domain(s)

♦DOMAIN 23 83 Sushi 1.
♦ DOMAIN 84 150 Sushi 2.
♦ DOMAIN 151 209 Sushi 3.
♦ DOMAIN 210 268 Sushi 4.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available