Reviewed
Homo Sapiens (Human) [TaxID: 9606]
ORF20[Gene ID: 4961477 ]
Protein UL24 homolog
Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Rhadinovirus> Human Herpesvirus 8 (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)> Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)
Various pathway(s) in which protein is involved
Not Available
MVRPTEAEVKKSLSRLPAARKRAGNRAHLATYRRLLKYSTLPDLWRFLSSRPQNPPLGHHRLFFEVTLGHRIADCVILVSGGHQPVCYVVELKTCLSHQL
IPTNTVRTSQRAQGLCQLSDSIHYIAHSAPPGTEAWTITPLLIFKNQKTLKTVYSESPGAFPTPVHTTEGKLCAFLTARENADIRKVLSKVPKKPKMDRG
GKILGPTPGKRAVYSQAHHGRNKKGRPWTAQPTRAKSRTKDKGTPAFPRAGPACSGP
IPTNTVRTSQRAQGLCQLSDSIHYIAHSAPPGTEAWTITPLLIFKNQKTLKTVYSESPGAFPTPVHTTEGKLCAFLTARENADIRKVLSKVPKKPKMDRG
GKILGPTPGKRAVYSQAHHGRNKKGRPWTAQPTRAKSRTKDKGTPAFPRAGPACSGP
257
Not Available
Not Available
21-03-2006
Evidence at transcript level
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
---|---|---|---|---|---|
Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
---|---|---|
May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity). Induces cell cycle arrest in host cells at the G2/M phase following by apoptosis. The mechanism involves the inhibition of host mitotic complex cyclin-B/CDK1.
Not Available
Virion . Host cytoplasm . Host nucleus, host nucleolus . Host Golgi apparatus .
Not Available
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available