Results | viHumans

UniProt ID

Q1HVH8

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

BOLF1[Gene ID: 5176199 ]

Protein Name

Inner tegument protein

Organism Name

Epstein-Barr Virus (strain AG876) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)> Epstein-Barr Virus (strain AG876) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

16490228

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:5176199

Reactome

Not Available

Sequence

							MASAMESDSGGGSGGADAQPPLAEVDGGLARVTRQLLLSGDDPAARLRALMPLELGIFGLGDLAQPVLVRDFLNTLTLMSGHAYPAAVLRHHAYYLLRAA
SFSRRSFGLGHLEAALDVLASSLPPTTASPATDDPLDGSRLIAETRALAATYRRIIEEGSGEVLAVSGPTATFAFVEELVADTYLARWDAFPREGLSFYA
FNAAKTTLGRWLVTVYAETNRYPWAAAGQGQPTAADIKAMAVELVEHSGGGAGGGEGEESGGGGLFHRPESLSSVVASLPLARRRAVEILGVYAEASGGQ
TPPVAAVPVLAFDAARLRLLEPSGALFYDYVYEALLWDQTYGVPDSVIEAFLAGMAAEMEALAARVQEAAGSRASFSPAAIEQVATVLLSAGLNETVAGD
YAMMLASVPRVSRSRWRWLEATAALLESLSGFALHFFRLLPTASPTSRFARVARAAYLRAEAEAVDRRARRTSGPSTPAAAPAATAVGVGAAADPWDAVT
PLRIFIVPPPAAEYEQVAGDLSSELLRSLLWVRYSRLWQAPAPAPALPCKPPLLPGEQGRRQWTAAVAAAPRTDVEAYCRSLRAGQTARADPAYVRSPFF
PAAFIEFQIWPALRRVLSNELPKTRSLAALRWLVSFGSDLALPSPELTRARRPLELIYATVWEIYDGAPPMPGESPQAVGLRPLNLEGEGKAGDAGAEGA
EDEEGGGPWGLSSHDAVLRIMDAVREVSGIISETISASERAAEAPPLAWPTSLFSLLFTLRYSTTAESLGLATRRFLVSGETLSEDISRLTGAAWRLCSR
PLLYDAETGRVQIPLATEEEEEAVVAVKEKSVSSSPRHYSTDLQTLKSVVEGIQDVCRDAAARWALATADTATLRRRLLVPALRESRGIADHPLWAHTSE
PLRPDLEELNERVEHALELGYSLTGALRRSVAYRFRDYTFARLFQPPAIDAERAEAIVRRDARPPPVFTPAPRRLPQGGADTPPPLSMDDILYLGKSICK
ALVDVLDHHPAAPETTPIKTYTPAMDLNPEQITVTPRSPSVLAAFARTARVQTHHLVPALTDDSPSPVGQTPPPFRILPAKKLAAILLGNGRNASKRRAS
RDLSPPPHGRWRAVLDSSPFSFSSSDFSDQDEGEGGEADLRGVPGGGGEGAYEEDRERPSDIDTAARAQKVETSCPRRRSPRTTPSPSRRASGGGGPDRG
EAEAHTYPPYLSAAAAASRVRPRTRRGATRRPPRPTAEDE
						

Length

1240

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

13-06-2006

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.

EC

Not Available

Experimentally known GO terms

GO:0019033 ; GO:0019068 ; GO:0042025 ; GO:0044177

Subcellular Location

Virion tegument . Host cytoplasm . Host nucleus . Host Golgi apparatus, host trans-Golgi network .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available