Reviewed
Homo Sapiens (Human) [TaxID: 9606]
Rex
Protein Rex (Rev homolog) (Rex-3)
Human T-cell Leukemia Virus 3 (strain 2026ND) (HTLV-3)
Viruses> Retro-transcribing Viruses> Retroviridae> Orthoretrovirinae> Deltaretrovirus> Primate T-lymphotropic Virus 3> Human T-cell Leukemia Virus 3 (HTLV-3) (Human T-lymphotropic Virus 3)> Human T-cell Leukemia Virus 3 (strain 2026ND) (HTLV-3)
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Various pathway(s) in which protein is involved
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MPKTRKQRSRRPKNQRPSTPWPISQVSDRAFSTGTLSTFSATVYRPIGAPFLGGFVPLGYTAMPYWPRAPNIRLPGTPSMDALSAQLYNTLSLDSPPSPP
RELPAPSRFSPPQPLLRPPRFLHPSSTPLKNTPPSETIALNSPWESSCQPCPSPTLGSDPKTSTPCGEAPLCAFTSISSPPP
RELPAPSRFSPPQPLLRPPRFLHPSSTPLKNTPPSETIALNSPWESSCQPCPSPTLGSDPKTSTPCGEAPLCAFTSISSPPP
182
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14-11-2006
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Rex escorts unspliced gag-pro-pol and singly spliced env mRNAs out of the nucleus of infected cells. These mRNAs carry a recognition sequence called Rex responsive element (RxRE or XRE) located at the 3' region of the long terminal repeat (LTR). This function is essential since most HTLV proteins are translated from unspliced or partially spliced pre-mRNAs that cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
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Host nucleus, host nucleolus . Host cytoplasm . Note=The presence of both nuclear import (NLS) and nuclear export (NES) signals leads to continuous shuttling between the nucleus and cytoplasm. .
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MOTIF 2 19 Nuclear localization signal, and RNA-binding (RxRE). ; MOTIF 83 94 Nuclear export signal.
Predicted/Modelled
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Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
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- Million Molecules
Best 20 Hit molecules
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