Results | viHumans

UniProt ID

Q09SZ8

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Rex

Protein Name

Protein Rex (Rev homolog) (Rex-3)

Organism Name

Human T-cell Leukemia Virus 3 (strain Pyl43) (HTLV-3)

Taxonomic Lineage

Viruses> Retro-transcribing Viruses> Retroviridae> Orthoretrovirinae> Deltaretrovirus> Primate T-lymphotropic Virus 3> Human T-cell Leukemia Virus 3 (strain Pyl43) (HTLV-3)

RefSeq

Not Available

PubMed ID

16973592

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MPKTRKQRSRRPRNQRPSTPWPISQVSDRAFSTGTLSTFSATVYRPIGAPFLGGFVPLGYTAMPCWPRAPNIRLPGTPSMDALSAQLYNTLSLGSPPSPP
KELPAPSRFSPPQPLLRPPRFLHPSSTPLKNTPPSETIASSSPWESSCQPCPSPTLGSGPKTSTPYGAAPSCVSTSISSPPP
						

Length

182

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

17-10-2006

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Rex escorts unspliced gag-pro-pol and singly spliced env mRNAs out of the nucleus of infected cells. These mRNAs carry a recognition sequence called Rex responsive element (RxRE or XRE) located at the 3' region of the long terminal repeat (LTR). This function is essential since most HTLV proteins are translated from unspliced or partially spliced pre-mRNAs that cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0030430 ; GO:0044196 ; GO:0051028

Subcellular Location

Host nucleus, host nucleolus . Host cytoplasm . Note=The presence of both nuclear import (NLS) and nuclear export (NES) signals leads to continuous shuttling between the nucleus and cytoplasm. .

Domain(s)

Not Available

Motif(s)

MOTIF 2 19 Nuclear localization signal, and RNA-binding (RxRE). ; MOTIF 83 94 Nuclear export signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available