Results | viHumans

UniProt ID

Q06095

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

DUT U45[Gene ID: 1487924 ]

Protein Name

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

Organism Name

Human Herpesvirus 6A (strain Uganda-1102) (HHV-6 Variant A) (Human B Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Betaherpesvirus 6A> Human Herpesvirus 6A (strain Uganda-1102) (HHV-6 Variant A) (Human B Lymphotropic Virus)

RefSeq

Not Available

PubMed ID

1333836 ; 7747482

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487924

Reactome

Not Available

Sequence

							MYSAISEKISETITLQRQTSSRYIEFFVFRNVDINELWTTDISEDKTHDVWPAVNEKSFKKFLENELTSYQRPIPLLGIPQNGTVSKTCKKEKQRETDCV
NYERKRGNPVTFYPRHRAKRNANTDTCISEEPSILVSHHRNSKMDVFMDTNKITLVNRELIWVPHDQVRIVKLDISLYIPDGFFGVITGHSNDVFCECVT
EIITDETDISVFLMNLSEHSLMLLPGDVEFSINFLPCYIPEPWEMINLSPPEFAIFHLKASREFIAKPNSYTIQYFDAMYVCADELKALMIPSKEIAKLG
LLIETYIWNKDTIPSIKIFNSTRKTIYIPTGICIARIIFTCGHFCLSLMPERAINRLQVLDANSSFLFHYAASNNA
						

Length

376

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1995

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.

EC

3.6.1.23

Experimentally known GO terms

GO:0004170 ; GO:0046080 ; GO:0046872

Subcellular Location

Not Available

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available