Results | viHumans

UniProt ID

Q04630

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

GM 18L U72[Gene ID: 1487953 ]

Protein Name

Envelope glycoprotein M (gM)

Organism Name

Human Herpesvirus 6A (strain Uganda-1102) (HHV-6 Variant A) (Human B Lymphotropic Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Roseolovirus> Human Betaherpesvirus 6A> Human Herpesvirus 6A (strain Uganda-1102) (HHV-6 Variant A) (Human B Lymphotropic Virus)

RefSeq

Not Available

PubMed ID

7844524 ; 7747482

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487953

Reactome

Not Available

Sequence

							MASSRVDTINLRIWLVSIICAALSFINVTVYLIAINFPNLGFPCAYFEINDLKAVNLSANNQIYQMTHQLYINPVQIICYVLIMAMLFLLIIIYYIVCCA
KVFSSNKTSNVNQTTRDITWMGDTSSCFQFILIMDTFQLFVTALSFRLVALGAFAYCIFFVCFTTFNVTLITQFQSADKSFFAFQKIHPNLKGTVQFKTV
VINLTELMLGYSTMFLGITTCLGVGNSIYIRSITVAYSSINTFLVMACIYSIVIEAVLVRYVKPLFGYYVGMFCGAVGLSFPILQYETFFESEWSTGLII
NLAVIAIISIGFIICRLVRYLVKKKRRYKQLVNTESSSLMDENE
						

Length

344

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0044175 ; GO:0044177 ; GO:0044201 ;
GO:0055036

Subcellular Location

♦ Virion membrane
♦ Multi-pass membrane protein . Host Golgi apparatus, host trans-Golgi network . Host endosome membrane
♦ Multi-pass membrane protein . Host nucleus inner membrane
♦ Multi-pass membrane protein . Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available