Results | viHumans

UniProt ID

Q04612

Status

Reviewed

Host

Bandicota Bengalensis (lesser Bandicoot Rat) [TaxID: 69079]; Callithrix [TaxID: 9481]; Cercopithecus Hamlyni (Owl-faced Monkey) (Hamlyn's Monkey) [TaxID: 9536]; Chlorocebus Aethiops (Green Monkey) (Cercopithecus Aethiops) [TaxID: 9534]; Gallus Gallus (Chicken) [TaxID: 9031]; Homo Sapiens (Human) [TaxID: 9606]; Macaca (macaques) [TaxID: 9539]; Mus Musculus (Mouse) [TaxID: 10090]; Pan Troglodytes (Chimpanzee) [TaxID: 9598]; Saimiri (squirrel Monkeys) [TaxID: 9520]; Sus Scrofa (Pig) [TaxID: 9823]

Gene Name

ORF3

Protein Name

Protein ORF3 (pORF3)

Organism Name

Hepatitis E Virus Genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Hepeviridae> Orthohepevirus> Orthohepevirus A> Hepatitis E Virus (HEV)> Hepatitis E Virus Genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)

RefSeq

NC_001434.1 ; L08816.1

PubMed ID

8470371

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MGSRPCDLGLFCCCSSCFCLCCPRHRPVSRLAAVVGGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPPMSPLRPGLDLVFANQPDHSAPLGVTRPSAPP
LPHVVDLPQLGPRR
						

Length

114

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

20-05-2008

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

May act as a viral regulatory protein involved in the modulation of mitogenic signaling pathways. May be involved in virion morphogenesis and viral pathogenesis. Expedites the processing and secretion of AMBP from the hepatocyte (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0016032 ; GO:0030430

Subcellular Location

Host cytoplasm . Note=The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available