Results | viHumans

UniProt ID

Q04360

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

BMLF1; BSLF2[Gene ID: 3783758 ]

Protein Name

mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)

Organism Name

Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)> Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

6087149 ; 10400785 ; 10846090 ; 11390605 ; 12403791 ; 16129689 ; 17699575 ; 18463151 ; 19793817 ;
22505578

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:17494210;vg:3783758

Reactome

Not Available

Sequence

							MVPSQRLSRTSSISSNEDPAESHILELEAVSDTNTDCDLDPMEGSEEHSTDGEISSSEEEDEDPTPAHAIPARPSSVVITPTSASFVIPRKKWDLQDKTV
TLHRSPLCRDEDEKEETGNSSYTRGHKRRRGEVHGCTDESYGKRRHLPPGARAPRAPRAPRVPRAPRSPRAPRSNRATRGPRSESRGAGRSTRKQARQER
SQRPLPNKPWFDMSLVKPVSKITFVTLPSPLASLTLEPIQDPFLQSMLAVAAHPEIGAWQKVQPRHELRRSYKTLREFFTKSTNKDTWLDARMQAIQNAG
LCTLVAMLEETIFWLQEITYHGDLPLAPAEDILLACAMSLSKVILTKLKELAPCFLPNTRDYNFVKQLFYITCATARQNKVVETLSSSYVKQPLCLLAAY
AAVAPAYINANCRRRHDEVEFLGHYIKNYNPGTLSSLLTEAVETHTRDCRSASCSRLVRAILSPGTGSLGLFFVPGLNQ
						

Length

479

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

26-05-2009

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Promotes the nuclear export of a subset of early and late viral mRNAs by interacting with mRNAs and cellular export proteins. Additionally may prevent the establishment of cellular antiviral state, by acting as an alternative splicing factor for cellular RNAs such as STAT1, resulting in a STAT1 mRNA incapable of producing the STAT1alpha isoform.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0006351 ; GO:0006355 ; GO:0030430 ; GO:0039502 ;
GO:0039580 ; GO:0044095 ; GO:0046872 ; GO:0051028

Subcellular Location

Host nucleus . Host cytoplasm . Note=shuttles between the nucleus and the cytoplasm.

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available