Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Pan Troglodytes (Chimpanzee) [TaxID: 9598]
P
♦Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7)
♦ RNA-directed DNA polymerase (EC 2.7.7.49)
♦ Ribonuclease H (EC 3.1.26.4)]
♦ RNA-directed DNA polymerase (EC 2.7.7.49)
♦ Ribonuclease H (EC 3.1.26.4)]
Hepatitis B Virus Genotype A1 Subtype Adw (isolate Philippines/pFDW294/1988) (HBV-A)
Viruses> Retro-transcribing Viruses> Hepadnaviridae> Orthohepadnavirus (mammalian Hepatitis B-type Viruses)> Hepatitis B Virus (HBV)> Hepatitis B Virus Subtype Adw (HBV)> Hepatitis B Virus Genotype A1 Subtype Adw (isolate Philippines/pFDW294/1988) (HBV-A)
Various pathway(s) in which protein is involved
Not Available
Not Available
MPLSYQHFRKLLLLDDETEAGPLEEELPRLADADLNRRVAEDLNLGNLNVSIPWTHKVGNFTGLYSSTVPIFNPEWQTPSFPKIHLHEDIANRCQQFVGP
LTVNEKRRLKLIMPARFYPNSTKYLPLDKGIKTYYPDHVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELHHGRLVIKTSQRHGDEPFC
SQPSGILSRSSVGPCIRSQFKQSRLGLQPHQGPLATSQPGRSGSIWARVHSPTRRCFGVEPSGSGHIGHRASDASSCLHQSAVRKAAYSHLSTSKRQSSS
GHAVEFHSFPPSSARSQSQGPVFSCWWLQFRNTQPCSNYCLSHLVNLLEDWGPCTEHGEHHIRIPRTPARVTGGVFLVDKNPHNTAESRLVVDFSQFSRG
STRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLIGSSGLSRYVARLSSNSRINNNQHGTLQNLHDSCSRQLYVSLMLLYKTYG
WKLHLYSHPIILGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGY
VIGSWGTLPQDHIVQKIKHCFRKLPVNRPIDWKVCQRLVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYMNLYPVARQRPGLCQVF
ADATPTGWGLAIGHQRMRETFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSQKYTSFPWLLGCTANWILRGTSFVYVPSALNPADDPSRGRLGLY
RPLLRLPYRPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP
LTVNEKRRLKLIMPARFYPNSTKYLPLDKGIKTYYPDHVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELHHGRLVIKTSQRHGDEPFC
SQPSGILSRSSVGPCIRSQFKQSRLGLQPHQGPLATSQPGRSGSIWARVHSPTRRCFGVEPSGSGHIGHRASDASSCLHQSAVRKAAYSHLSTSKRQSSS
GHAVEFHSFPPSSARSQSQGPVFSCWWLQFRNTQPCSNYCLSHLVNLLEDWGPCTEHGEHHIRIPRTPARVTGGVFLVDKNPHNTAESRLVVDFSQFSRG
STRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLIGSSGLSRYVARLSSNSRINNNQHGTLQNLHDSCSRQLYVSLMLLYKTYG
WKLHLYSHPIILGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGY
VIGSWGTLPQDHIVQKIKHCFRKLPVNRPIDWKVCQRLVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYMNLYPVARQRPGLCQVF
ADATPTGWGLAIGHQRMRETFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSQKYTSFPWLLGCTANWILRGTSFVYVPSALNPADDPSRGRLGLY
RPLLRLPYRPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP
845
Not Available
Not Available
18-03-2008
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
2.7.7.7 , 2.7.7.49 , 3.1.26.4
Not Available
DOMAIN 359 602 Reverse transcriptase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available