Reviewed
Bos Taurus (Bovine) [TaxID: 9913]; Canis Lupus Familiaris (Dog) (Canis Familiaris) [TaxID: 9615]; Cervinae [TaxID: 34878]; Equus Caballus (Horse) [TaxID: 9796]; Homo Sapiens (Human) [TaxID: 9606]; Ixodes Ricinus (Common Tick) [TaxID: 34613]; Ovis Aries (Sheep) [TaxID: 9940]; Sus Scrofa (Pig) [TaxID: 9823]
Not Available
Genome polyprotein [Cleaved into: Envelope protein E] (Fragment)
Louping Ill Virus (strain SB 526) (Li)
Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Flaviviridae> Flavivirus (arboviruses Group B)> Tick-borne Encephalitis Virus Group> Louping Ill Virus (Li)> Louping Ill Virus (strain SB 526) (Li)
Various pathway(s) in which protein is involved
Not Available
Not Available
SRCTHLENRDFVTGTQGTTRVTLVLELGGCVTITAEGKPSVDVWLDAIYQESPAKTREYCLHAKLSETKVAARCPTMGPAALAEERQIGTVCKRDQSDRG
WGNHCGLFGKGSIVACVKAACEAKKKATGYVYDANKIVYTVKVEPHTGDYVAANETHKGRKTATFTVSSEKTILTLGEYGDVSLLCRVASGVDLAQTIIL
ELDKTAEHLPTAWQVHRDWFNDLALPWKHEGNPHWNNAERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGNKYHLKSGHVTCEVGLEKLKMK
GLTYTMCDKSKFAWKRTPTDSGHDTVVMEVTFSGSKPCRIPVRAVAHGSPDVNVAMLITPNPTIENDGGGFIEMQLPPGDNIIYVGELSHQWFQTGSSIG
RVFQKTRKGIERLTVIGEHAWDFGSAGGFFSSIGKAVHTVLGGAFNSIFGGVGFLPKLLMGVALAWLGLNTRNPTMSISFLLTGGLVLAMTLGVGA
WGNHCGLFGKGSIVACVKAACEAKKKATGYVYDANKIVYTVKVEPHTGDYVAANETHKGRKTATFTVSSEKTILTLGEYGDVSLLCRVASGVDLAQTIIL
ELDKTAEHLPTAWQVHRDWFNDLALPWKHEGNPHWNNAERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGNKYHLKSGHVTCEVGLEKLKMK
GLTYTMCDKSKFAWKRTPTDSGHDTVVMEVTFSGSKPCRIPVRAVAHGSPDVNVAMLITPNPTIENDGGGFIEMQLPPGDNIIYVGELSHQWFQTGSSIG
RVFQKTRKGIERLTVIGEHAWDFGSAGGFFSSIGKAVHTVLGGAFNSIFGGVGFLPKLLMGVALAWLGLNTRNPTMSISFLLTGGLVLAMTLGVGA
496
Not Available
Not Available
01-10-1993
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Envelope protein E: Binds to host cell surface receptor and mediates fusion between viral and cellular membranes. Envelope protein is synthesized in the endoplasmic reticulum in the form of heterodimer with protein prM. They play a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimer between precursor prM and envelope protein E. The virion is transported to the Golgi apparatus where the low pH causes dissociation of PrM-E heterodimers and formation of E homodimers. prM-E cleavage is ineficient, and many virions are only partially matured. These uncleaved prM would play a role in immune evasion.
Not Available
GO:0016021 ; GO:0019031 ; GO:0019062 ; GO:0039654 ; GO:0044167 ;
GO:0046983 ; GO:0055036 ; GO:0075512
GO:0046983 ; GO:0055036 ; GO:0075512
♦ Envelope protein E: Virion membrane
♦ Multi-pass membrane protein . Host endoplasmic reticulum membrane
♦ Multi-pass membrane protein .
♦ Multi-pass membrane protein . Host endoplasmic reticulum membrane
♦ Multi-pass membrane protein .
Not Available
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available